47 completed, 14 unknown, 7 withdrawn, 6 terminated. 23 Not applicable, 20 Phase 4, 19 Phase 2, 13 Phase 3, 11 Phase 1.
Follow Midodrine: new trials by email Literature Review of Midodrine trials Research Report on Midodrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension Midodrine Oral Tablet - Heart Failure With Reduced Ejection Fraction, Hypotension | Phase 2 / Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 56 | 2026-08-07 | 2026-09-08 |
| Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure. Midodrine, Standard Medical Treatment - Acute on Chronic Liver Failure | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 113 | 2026-02-05 | 2026-02-20 |
| MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial Midodrine, Standard of Care - Sepsis, Low Blood Pressure | Phase 2 | Recruiting | Mayo Clinic | 308 | 2024-05-14 | 2026-08-31 |
| Evaluation of Low-dose Albumin and Midodrine Versus Midodrine Alone in Outcome of Recurrent Ascites in Patients With Decompensated Cirrhosis. Albumin, Midodrine, Standard of Care - Decompensated Cirrhosis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 100 | 2024-02-10 | 2024-02-07 |
| Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section: A Prospective Double-blind Randomized Clinical Trial Norepinephrine, Midodrine - Post Spinal Anesthesia Hypotension | Not applicable | Unknown | Sohag University | 90 | 2024-02-01 | 2024-01-19 |
| Midodrine Plus Albumin Versus Midodrine Alone to Prevent Cirrhosis Related Complications in Children With Cirrhosis and Ascites Midodrine, albumin, Standard Medical Treatment - Liver Cirrhosis | Not applicable | Completed | Institute of Liver and Biliary Sciences, India | 61 | 2023-12-22 | 2026-03-10 |
| Pharmacological Enhancement of Glymphatic Function in Humans Dexmedetomidine, Dexmedetomidine and Midodrine, Placebo - Alzheimer Disease | Phase 1 / Phase 2 | Completed | Applied Cognition | 31 | 2023-12-11 | 2026-02-25 |
| Treatment of Orthostatic Hypotension in SCI Midodrine Hydrochloride - Hypotension | Phase 4 | Recruiting | James J. Peters Veterans Affairs Medical Center | 25 | 2023-07-01 | 2026-08-10 |
| Treatment Strategy of Vasovagal Syncope Cardioneuroablation, Midodrine Oral Tablet - Syncope, Vasovagal | Not applicable | Unknown | China National Center for Cardiovascular Diseases | 184 | 2023-04-05 | 2024-03-21 |
| Midodrine Effect on the Mortality Rates in Septic Shock Patients Midodrine Oral Tablet - Septic Shock | Phase 2 | Completed | Noha Mansour | 100 | 2022-11-07 | 2025-03-03 |
| Midodrine for Prophylaxis Against Post Spinal Hypotension in Elderly Population Midodrine Oral Tablet, Metoclopramide - Hypotension, Spinal Anesthesia | Not applicable | Completed | Cairo University | 58 | 2022-10-17 | 2023-09-15 |
| To Assess the Efficacy of Midodrine in Prevention of Cirrhosis Related Complications in Children Awaiting Liver Transplantation. Midodrine Oral Tablet, Standard Medical Treatment - Cirrhosis, Liver | Not applicable | Completed | Institute of Liver and Biliary Sciences, India | 35 | 2022-01-01 | 2023-10-10 |
| Efficacy and Safety of Midodrine in Refractory or Recurrent Ascites in Children With Cirrhosis. Midodrine, Standard medical treatment - Refractory Ascites in Children With Cirrhosis | Not applicable | Withdrawn | Institute of Liver and Biliary Sciences, India | 2021-11-01 | 2024-05-07 | |
| To Study Effect of the Combination of Midodrine and Tolvaptan Versus Tolvaptan Alone in Patients With Severe Hyponatremia in Cirrhosis(TOLMINA Trial) Tolvaptan Tablets, Midodrine Oral Tablet, Placebo - Liver Cirrhosis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 220 | 2021-09-19 | 2021-11-29 |
| Angiotensin 2 for Hepatorenal Syndrome Angiotensin II, Midodrine, Octreotide - Hepatorenal Syndrome, Cirrhosis | Phase 2 | Withdrawn | University of California, Los Angeles | 2021-07-01 | 2024-03-06 | |
| Evaluation of Albumin and Midodrine Versus Albumin Alone in Outcome of Refractory Ascites in Patients With Decompensated Cirrhosis. Midodrine, Albumin, Standard Medical Treatment - Liver Cirrhosis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 200 | 2021-05-15 | 2021-06-15 |
| Midodrine for the Early Liberation of Vasopressor Support in the ICU Midodrine, Placebo - Critical Illness, Shock | Phase 4 | Completed | University of Alberta | 20 | 2021-03-22 | 2023-10-06 |
| Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site) Midodrine, Placebo - Vasoplegia | Phase 4 | Recruiting | University of Alberta | 870 | 2021-03-22 | 2026-01-20 |
| Midodrine Versus Albumin for Prevention of Paracentesis Induced Circulatory Disturbance Midodrine Hydrochloride, Human Albumin 20% - Paracentesis-Induced Circulatory Dysfunction | Phase 3 | Completed | Asian Institute of Gastroenterology, India | 50 | 2021-02-20 | 2022-05-10 |
| Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms Accelerometer, placebo pill, Midodrine or atomoxetine pill - Orthostatic; Hypotension, Neurogenic, Autonomic Failure | Not applicable | Recruiting | Vanderbilt University Medical Center | 29 | 2021-02-05 | 2026-07-02 |
Showing 20 of 81. Sign in to see all of them.
Hypotension, Orthostatic (17) · Fibrosis (10) · Hypotension (10) · Ascites (8) · Spinal Cord Injuries (7) · Hepatorenal Syndrome (6) · Pure Autonomic Failure (6) · Multiple System Atrophy (5) · Shock, Septic (5) · Liver Cirrhosis (4) · Sepsis (4) · Parkinson Disease (3) · Renal Insufficiency (3) · Syncope, Vasovagal (3) · Acute Kidney Injury (2)
Institute of Liver and Biliary Sciences, India (12) · James J. Peters Veterans Affairs Medical Center (7) · Shire (5) · Vanderbilt University Medical Center (5) · Mayo Clinic (3) · Mylan Pharmaceuticals Inc (3) · University of Alberta (3) · Hospital Clinic of Barcelona (2) · Post Graduate Institute of Medical Education and Research, Chandigarh (2) · Seoul National University Hospital (2) · US Department of Veterans Affairs (2) · University of Virginia (2) · Ahmed talaat ahmed aly (1) · Ain Shams University (1) · Anna Cruceta (1)
United States (39) · India (14) · Canada (6) · Egypt (6) · Spain (3) · Poland (2) · South Korea (2) · Australia (1) · China (1) · Czechia (1) · Denmark (1) · Iran (1) · Italy (1) · Slovakia (1)
Italo Biaggioni, MD (5) · Thomas S Clark, M.D. (3) · Horacio Kaufmann (2) · Jill M Wecht, Ed.D (2) · Jill Wecht, EdD (2) · John P Handrakis, PT, DPT, EdD (2) · Luis E Okamoto, MD (2) · Achuthan Sourianarayanane (1) · Ahmed T Ahmed, lecture (1) · Albert Cheung, MD (1) · Alexandra Kadl, MD (1) · Amos Lal, MBBS (1) · Andrei Krassioukov, MD PhD (1) · Arash Jalali, PhD (1)
PMID 21762873, PMID 28327122, PMID 34339231, PMID 10347109, PMID 10662747, PMID 11772973, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12832331, PMID 15066944, PMID 15710782, PMID 15738343, PMID 15911704, PMID 16460491, PMID 17515447, PMID 17515448, PMID 18251131, PMID 18410283, PMID 18492024, PMID 18547224, PMID 19687359, PMID 20801263, PMID 20837887, PMID 22095893, PMID 22311903, PMID 22610268, PMID 22801062, PMID 23845791, PMID 24002370, PMID 24100756, PMID 24227635, PMID 24495468, PMID 24606242, PMID 24721800, PMID 25531297, PMID 26492477, PMID 26953217, PMID 27271310, PMID 27372462, PMID 27614145, PMID 28794253, PMID 29223724, PMID 30138685, PMID 31107279, PMID 31330187, PMID 31334462, PMID 32145658, PMID 32203065, PMID 32274344
R01HL144568 (3), R01NS042607 (1), R61HL177037 (1), UL1TR000445 (1)