180 completed, 65 recruiting, 57 unknown, 33 active not recruiting. 187 Not applicable, 51 Phase 2, 23 Phase 1, 22 Phase 3, 20 Phase 4.
Follow this condition Literature Review of Orthostatic Intolerance trials Research Report on Orthostatic Intolerance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity breathing exercise training - Postural Tachycardia Syndrome | Not applicable | Not yet recruiting | Virginia Commonwealth University | 12 | 2028-01-01 | 2026-09-16 |
| Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial) Tamsulosin hydrochloride 0.2 mg, Placebo - Benign Prostatic Hyperplasia | Phase 4 | Not yet recruiting | Shanghai East Hospital | 400 | 2026-12-01 | 2026-09-29 |
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| Continuous and Non-invasive Measurements by Task Force® CORE/CARDIO in Autonomic Function Testing (AFT) Autonomic Function Testing - Autonomic Dysfunction, Orthostatic Intolerance | Not yet recruiting | CNSystems Medizintechnik GmbH | 75 | 2026-11-01 | 2026-03-18 | |
| The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome | Not yet recruiting | AI Agent Vault, Inc. d/b/a Precision Mito | 400 | 2026-11-01 | 2026-10-02 | |
| Cardiovascular Autonomic Function After Resistance Training Upper-Limb Resistance Training - Spinal Cord Injury | Not applicable | Not yet recruiting | Pusan National University Yangsan Hospital | 20 | 2026-10-01 | 2026-09-03 |
| RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome Bilateral Sequential Stellate Ganglion Block - POTS - Postural Orthostatic Tachycardia Syndrome | Not applicable | Not yet recruiting | University Medical Centre Ljubljana | 30 | 2026-10-01 | 2026-09-24 |
| aVNT in POTS - Pilot active aVNT vs. Sham - Postural Orthostatic Tachycardia Syndrome (POTS) | Not applicable | Not yet recruiting | University of Calgary | 30 | 2026-09-01 | 2026-05-01 |
| Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury Tilt test with stimulation (real-time effects): Intervention 1, 20 sessions of stimulation (Intervention 2) - Spinal Cord Injuries, Hypotension | Not applicable | Not yet recruiting | Kessler Foundation | 10 | 2026-09-01 | 2026-06-29 |
| NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease Droxidopa Oral Product, Placebo Control - Menkes Disease | Phase 1 / Phase 2 | Recruiting | Stephen G. Kaler | 6 | 2026-08-10 | 2026-10-05 |
| Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE) Wearable holter monitor - Orthostatic Hypotension, Reflex Syncope | Recruiting | Boston Scientific Corporation | 40 | 2026-08-06 | 2026-10-14 | |
| Low Dose Naltrexone Use in Patients With POTS Low Dose Naltrexone, Microcrystalline cellulose - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Not yet recruiting | University of Calgary | 80 | 2026-07-01 | 2026-05-01 |
| State of Knowledge Among Nurses Regarding the Screening for Orthostatic Hypotension in Elderly Individuals in Acute Geriatric Medicine and Medical and Rehabilitation Services Administration of questionnaires on nurses' knowledge of orthostatic hypotension, its measurement, diagnosis and management - Orthostatic Hypotension | Not yet recruiting | Hôpital NOVO | 30 | 2026-07-01 | 2026-07-31 | |
| Presentation of Young Adults With and Without Joint Hypermobility Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) | Not yet recruiting | Clarkson University | 100 | 2026-06-20 | 2026-06-22 | |
| Beta-3 Enhanced Autonomic Therapy for POTS Mirabegron, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS) | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 36 | 2026-05-01 | 2026-05-13 |
| Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study Sarcopenia, Fatigue | Not yet recruiting | Ain Shams University | 90 | 2026-05-01 | 2026-05-04 | |
| Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65) Orthostatic Hypotension, Postprandial Hypotension | Not yet recruiting | University Medical Centre Ljubljana | 500 | 2026-04-01 | 2026-03-20 | |
| Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease Whole-body Electrical Muscle Stimulation Exercise - Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | University of Missouri-Columbia | 50 | 2026-03-10 | 2026-03-17 |
| Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension Intelligent diagnostic system for orthostatic hypotension - Orthostatic Hypotension | Not yet recruiting | Xuanwu Hospital, Beijing | 2000 | 2026-03-01 | 2026-01-07 | |
| Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome? Swimming, Cycling - ME/CFS, Long COVID | Not applicable | Suspended | Simon Fraser University | 50 | 2026-02-20 | 2026-03-30 |
Showing 20 of 393. Sign in to see all of them.
Hypotension, Orthostatic (149) · Postural Orthostatic Tachycardia Syndrome (134) · Syncope, Vasovagal (88) · Syncope (47) · Spinal Cord Injuries (30) · Autonomic Nervous System Diseases (29) · Pure Autonomic Failure (23) · Parkinson Disease (22) · Post-Exercise Hypotension (22) · Hypotension (20) · Primary Dysautonomias (19) · Multiple System Atrophy (18) · Post-Acute COVID-19 Syndrome (18) · Hypertension (17)
Nervous System Diseases (388) · Primary Dysautonomias (374) · Autonomic Nervous System Diseases (364) · Pathological Conditions, Signs and Symptoms (198) · Cardiovascular Diseases (196) · Vascular Diseases (180) · Signs and Symptoms (175) · Neurologic Manifestations (165) · Hypotension (155) · Neurobehavioral Manifestations (104) · Consciousness Disorders (102) · Unconsciousness (100) · Central Nervous System Diseases (73) · Pathologic Processes (68)
Midodrine (23) · Droxidopa (16) · Saline Solution (9) · Exercise (8) · Pyridostigmine Bromide (8) · Sodium Chloride (8) · Atomoxetine Hydrochloride (7) · Propranolol (7) · Tilt-Table Test (6) · Ivabradine (5) · Phenylephrine (5) · Blood Specimen Collection (3) · Lower Body Negative Pressure (3) · Melatonin (3) · Metoprolol (3)
Vanderbilt University Medical Center (27) · University of Calgary (18) · Vanderbilt University (17) · James J. Peters Veterans Affairs Medical Center (8) · Mayo Clinic (8) · National Institute of Neurological Disorders and Stroke (NINDS) (8) · Istituto Auxologico Italiano (6) · New York Medical College (6) · Satish R. Raj (6) · University of British Columbia (6) · Centre of Postgraduate Medical Education (5) · Chelsea Therapeutics (5) · VA Office of Research and Development (5) · Kessler Foundation (4) · Shire (4)
United States (199) · Canada (44) · Italy (19) · France (15) · Poland (14) · Denmark (12) · Spain (12) · United Kingdom (11) · Brazil (10) · Netherlands (10) · Germany (9) · Sweden (8) · Australia (7) · Switzerland (6) · Austria (5)
Italo Biaggioni, MD (16) · Satish R Raj, MD MSCI (15) · Alfredo J Gamboa, MD (4) · Cyndya Shibao, M.D (4) · Jill Wecht, EdD (4) · Satish R Raj, MD, MSCI (4) · Nicole Harbert (3) · Roy Freeman, MD (3) · Victoria E Claydon, PhD (3) · David Robertson, MD (2) · David Systrom, MD (2) · Emily M Garland, PhD (2)
PMID 15670960, PMID 21712276, PMID 36114133, PMID 38036236, PMID 21762873, PMID 22565936, PMID 27538531, PMID 28494751, PMID 30354289, PMID 15710782, PMID 19797151, PMID 22275485, PMID 26411271, PMID 27402231, PMID 29562304, PMID 30338504, PMID 31330187, PMID 31439288, PMID 33279955, PMID 33739123, PMID 34339231, PMID 10037110, PMID 10662747, PMID 11018167, PMID 11146266, PMID 11210997, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12239256, PMID 12832331, PMID 12885750, PMID 15066944, PMID 15297344, PMID 15451153, PMID 15666063, PMID 15738343, PMID 15758011, PMID 15911704, PMID 16731474, PMID 16781217, PMID 16943900, PMID 17384373, PMID 17385265, PMID 17515447, PMID 17515448, PMID 17709712, PMID 17903630, PMID 17951266, PMID 17965289
R01HL102387 (4), K23RR020783 (2), P01HL056693 (2), P01NS044233 (2), R01HL144568 (2), U54NS065736 (2), UL1RR024975 (2), 2015 (1), 2017 (1), 2018 (1), 2019 (1), 5UL1TR000445-07 (1), I21RX004373 (1), IK1RX003706 (1), K23HD102663 (1)