11 recruiting, 10 completed, 4 active not recruiting, 3 unknown. 11 Not applicable, 6 Phase 2, 5 Phase 1, 3 Early Phase 1, 2 Phase 3.
Follow Shy-Drager Syndrome: new trials by email Literature Review of Shy-Drager Syndrome trials Research Report on Shy-Drager Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous Stem Cell Therapy in Patients With Multiple System Atrophy MSCs, Placebo - MSA - Multiple System Atrophy, MSA | Phase 2 | Not yet recruiting | Biocells Medical | 50 | 2026-09-01 | 2026-03-11 |
| Remote Monitoring in Progressive Supranuclear Palsy (PSP) Progressive Supranuclear Palsy, Parkinson Disease | Not yet recruiting | Massachusetts General Hospital | 85 | 2026-09-01 | 2026-07-29 | |
| Test-retest Trial With [11C]MODAG-005 in PD or MSA and AMHC - Pilot Phase [11C]MODAG-005 - Parkinson Disease (PD), MSA - Multiple System Atrophy | Early Phase 1 | Recruiting | MODAG GmbH | 9 | 2026-07-29 | 2026-07-31 |
| Invasive Home Ventilation in Denmark Neuromuscular Diseases (NMD), ALS (Amyotrophic Lateral Sclerosis) | Recruiting | Copenhagen University Hospital, Rigshospitalet | 450 | 2026-04-13 | 2026-04-20 | |
| Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1 - Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 300 | 2026-02-13 | 2026-04-03 |
| Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease. Administration of Carbidopa/levodopa - Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic | Phase 1 / Phase 2 | Recruiting | Julien Bally | 36 | 2025-07-18 | 2026-01-29 |
| Epidural Electrical Stimulation to Support Hemodynamic Management in Individuals With Parkinson's Disease ARC-IM Investigational System - Hypotension Symptomatic, Parkinson's Disease | Not applicable | Recruiting | Ecole Polytechnique Fédérale de Lausanne | 5 | 2025-07-03 | 2026-07-07 |
| Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury spinal cord transcutaneous stimulation, Ice testing - Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic | Not applicable | Recruiting | Kessler Foundation | 15 | 2025-04-01 | 2026-07-01 |
| The STAND-UP Study Angioplasty or stenting - Orthostatic Hypotension, Dysautonomic, Orthostatic Intolerance | Not applicable | Recruiting | St. Francis Hospital, New York | 100 | 2025-01-23 | 2025-09-29 |
| The CurePSP Genetics Program Whole genome sequencing will be performed at the NIH - PSP, PSP - Progressive Supranuclear Palsy | Recruiting | Massachusetts General Hospital | 1000 | 2024-10-08 | 2026-01-14 | |
| [18F]-MFBG Versus [123I]-MIBG and [18F]-PE2I in PD vs. MSA and DLB vs. AD [18F]-MFBG PET CT, [18F]-FE-PE2I PET CT or PET MRI, [123I]-MIBG SPECT CT - Parkinson Disease, Dementia With Lewy Bodies | Phase 2 / Phase 3 | Recruiting | prof. dr. Koen Van Laere | 113 | 2024-01-19 | 2025-02-06 |
| Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease Parkinson Disease, MSA - Multiple System Atrophy | Active not recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 180 | 2023-10-03 | 2026-08-28 | |
| Integrated Management of Atypical Parkinsonism: A Home-based Patient-Centered Healthcare Delivery Based on Telenursing (IMPACT Study) Telemonitoring, Standard-of-care - Atypical Parkinsonism, MSA - Multiple System Atrophy | Not applicable | Active not recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 164 | 2023-08-17 | 2026-03-27 |
| Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy Ampreloxetine, Placebo - Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy | Phase 3 | Active not recruiting | Theravance Biopharma | 102 | 2023-06-27 | 2025-09-05 |
| A Biomarker Study of ATH434 in Participants With MSA ATH434 - Multiple System Atrophy | Phase 2 | Completed | Alterity Therapeutics | 10 | 2023-05-23 | 2025-04-01 |
| Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders 18F-PBR06 - Neurodegenerative Diseases, sca3 | Unknown | Brigham and Women's Hospital | 50 | 2023-03-01 | 2023-05-22 | |
| Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Long COVID stellate ganglion block with 0.5% bupivacaine - Post Acute COVID-19 Syndrome, Long COVID | Phase 1 | Completed | Jonathann Kuo, MD | 20 | 2023-01-03 | 2025-03-13 |
| Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early to Moderate Stage Multiple System Atrophy (MSA) hOMSC300 - Multiple System Atrophy, MSA - Multiple System Atrophy | Phase 1 | Active not recruiting | Cytora Ltd. | 10 | 2022-11-07 | 2025-01-29 |
| Study of ATH434 in Participants with Multiple System Atrophy ATH434 dose level 1, ATH434 dose level 2, Placebo - Multiple System Atrophy | Phase 2 | Completed | Alterity Therapeutics | 77 | 2022-07-01 | 2024-12-13 |
| MotIoN aDaptive Deep Brain Stimulation for MSA Deep brain stimulation - MSA - Multiple System Atrophy | Not applicable | Completed | University of Oxford | 3 | 2021-12-03 | 2025-11-17 |
Showing 20 of 33. Sign in to see all of them.
Parkinson Disease (13) · Multiple System Atrophy (10) · Pure Autonomic Failure (6) · Hypotension, Orthostatic (5) · Lewy Body Disease (5) · Neurodegenerative Diseases (5) · Supranuclear Palsy, Progressive (5) · Alzheimer Disease (3) · Amyotrophic Lateral Sclerosis (3) · Dementia (3) · Hypertension (3) · Movement Disorders (3) · Primary Dysautonomias (3) · Spinal Cord Injuries (3)
Basal Ganglia Diseases (33) · Brain Diseases (33) · Cardiovascular Diseases (33) · Central Nervous System Diseases (33) · Vascular Diseases (33) · Hypotension (32) · Nervous System Diseases (32) · Autonomic Nervous System Diseases (31) · Movement Disorders (30) · Primary Dysautonomias (30) · Multiple System Atrophy (23) · Synucleinopathies (18) · Neurodegenerative Diseases (17) · Pathological Conditions, Signs and Symptoms (14) · Parkinsonian Disorders (11)
Deep Brain Stimulation (2) · Pseudoephedrine (2) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 8-hydroxyquinazolin-4(3H)-one (1) · ATH434 (1) · Acetates (1) · Angioplasty (1) · Arginine (1) · Aspirin (1) · Aspirin, Dipyridamole Drug Combination (1) · Bosentan (1) · Bupivacaine (1) · Captopril (1) · Carbidopa (1) · Clonidine (1)
Vanderbilt University (3) · Alterity Therapeutics (2) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (2) · Massachusetts General Hospital (2) · University of Oxford (2) · Bastyr University (1) · Biocells Medical (1) · Brigham and Women's Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Cytora Ltd. (1) · Ecole Polytechnique Fédérale de Lausanne (1) · Icahn School of Medicine at Mount Sinai (1) · Jonathann Kuo, MD (1) · Julien Bally (1) · Juvantia Pharma Ltd (1)
United States (18) · France (4) · Italy (4) · United Kingdom (4) · Australia (2) · Belgium (2) · Canada (2) · Denmark (2) · Germany (2) · Israel (2) · New Zealand (2) · Poland (2) · Portugal (2) · Switzerland (2) · Argentina (1)
Italo Biaggioni, MD (3) · Alexander L Green, FRCS(SN) (1) · Anne-Marie A Wills, MD MPH (1) · Einat Engel-Haber, MD (1) · Emily M Garland, PhD, MSCI (1) · Fabio Moda, PHD (1) · Horacio Kaufmann, MD (1) · Jeffrey Weiss, MD (1) · Jocelyne Bloch, MD (1) · Jonathann Kuo, MD (1) · Karthikeyan M Arcot, MD (1) · Koen Van Laere (1) · Laurie K Mischley, ND, PhD, MPH (1) · Olivier Rascol, MD (1)
PMID 10851208, PMID 11927799, PMID 12119802, PMID 12885750, PMID 12923400, PMID 15666063, PMID 15738343, PMID 16391172, PMID 16533484, PMID 17116758, PMID 18426998, PMID 19047577, PMID 19738158, PMID 22469621, PMID 22801444, PMID 23266540, PMID 28800338, PMID 38082255, PMID 40190837, PMID 40924149, PMID 9369256, PMID 9890307
2023 (1), P01HL056693 (1), UL1TR000445 (1)