55 completed, 14 unknown, 5 recruiting, 4 terminated. 31 Not applicable, 27 Phase 4, 12 Phase 2, 12 Phase 3, 2 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension Normal Saline, Ephedrine - Postinduction Hypotension | Not applicable | Recruiting | Cairo University | 124 | 2026-08-04 | 2026-08-06 |
| Norepinephrine With Ephedrine Versus Norepinephrine Alone During Spinal Anesthesia for Cesarean Delivery Ephedrine and Norepinephrine infusion, Norepinephrine infusion - Incidence of Post-spinal Hypotension | Phase 4 | Recruiting | Cairo University | 260 | 2026-06-01 | 2026-10-21 |
| Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal Anesthesia Norepinephrine, Ephedrine - Cesarean Delivery Affecting Newborn, Acidosis | Phase 4 | Completed | mehmet özkılıç | 155 | 2025-09-01 | 2026-10-08 |
| Management of Post-Induction Hypotension in Emergency Abdominal Surgery Ephedrine (6 mg boluses), Norepinephrine (10 µg boluses) - Post-induction Hypotension | Phase 4 | Terminated | Hopital Charles Nicolle | 100 | 2025-03-06 | 2025-12-11 |
| Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine Ephedrine, Norepinephrine - Ephedrine, Norepinephrine | Not yet recruiting | Riverside University Health System Medical Center | 10000 | 2025-02-20 | 2025-02-25 | |
| Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients Ephedrine Hydrochloride 30 mg/ml, Saline (NaCl 0,9 %) (placebo) - Neuromuscular Blockade | Phase 4 | Completed | Matias Vested | 80 | 2025-01-13 | 2026-09-11 |
| Ephedrine Versus Phenylephrine for Spinal Block - Related Hypotension in Cesarean Delivery Ephedrine, Phenylephrine - Spinal Anesthesia, Cesarean Delivery | Completed | Centre of Postgraduate Medical Education | 94 | 2024-12-16 | 2025-09-19 | |
| Comparison of Prophylactic Continuous Infusion of Norepinephrine, Ephedrine, and Their Combination for Prevention of Hypotension During Spinal Anaesthesia for Caesarean Delivery continuous infusion of noreadrenaline at a fixed rate of 30 ml/min of 4ug/ml, continious ephedrine infusion at a rate of 30 ml/min, Patients will receive a combined infusion of norepinephrine 2 µg/min and ephedrine 2 mg/min. - Maternal Hypotension After Spinal Anesthesia | Not applicable | Active not recruiting | Alexandria University | 60 | 2024-09-27 | 2026-10-27 |
| Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis The tetralogy of medication regimen - Atrial Fibrillation | Completed | Chinese Academy of Medical Sciences, Fuwai Hospital | 106 | 2024-08-01 | 2025-08-22 | |
| Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine Norepinephrine, Ephedrine - Anesthesia Complication, Vasopressor | Not applicable | Completed | Hopital Charles Nicolle | 196 | 2024-08-01 | 2026-04-23 |
| Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery Ketalar, Ephedrine - Post Spinal Hypotension | Phase 1 | Completed | Ain Shams University | 100 | 2024-04-01 | 2025-06-24 |
| Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation. Dexmedetomidine infusion, Dexmedetomidine bolus, Atropine Sulfate - Dexmedetomidine, Intubation Complication | Phase 2 | Completed | Kasr El Aini Hospital | 70 | 2024-04-01 | 2026-07-09 |
| Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study Ephedrine, Phenylephrine, Norepinephrine - Postpartum Hemorrhage | Not applicable | Recruiting | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 96 | 2024-03-18 | 2026-04-06 |
| Evaluation of Post-Induction Hypotension Treatment with PRAM Method Ephedrine, Noradrenalin - Hypotension on Induction | Active not recruiting | Ankara City Hospital Bilkent | 100 | 2024-03-01 | 2025-03-05 | |
| Appropriate Dosage of Vasopressor in Neonates and Infants EPHEDrine Hydrochloride 5 mg/ml - Hypotension, Neonatal Hypotension | Phase 4 | Not yet recruiting | Seoul National University Hospital | 132 | 2024-02-15 | 2024-02-15 |
| Could Ephedrine Replace Dexmedetomidine Fordexmedetomidine Prevention of Shivering in Women Undergoing Cesarean Section Under Spinal Anaesthesia Ephedrine, Dexmedetomidine - Prevention of Shivering With Spinal Anaesthesia | Not applicable | Unknown | Assiut University | 200 | 2024-02-10 | 2024-01-31 |
| Cerebral Flow-metabolism Coupling During Adult Surgery Propofol, Sevoflurane, Ephedrine - Anesthesia | Phase 4 | Unknown | Jason Chui | 80 | 2023-10-03 | 2023-10-18 |
| Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part) Ephedrine, Phenylephrine, Norepinephrine - Carotid Endarterectomy | Not applicable | Unknown | Beijing Tiantan Hospital | 60 | 2023-09-30 | 2023-08-24 |
| Comparative Study Among Different Doses of Ephedrine During Elective Cesarean Section Under Subarachnoid Block. Ephedrine 5mg, Ephedrine 10mg, Ephedrine 15mg - Anesthesia, Cesarean Section Complications | Phase 4 | Completed | Aswan University | 300 | 2023-08-20 | 2024-03-01 |
| The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients Slow dose preemptive Atropine, Ephedrine - Pregnancy, Cesarean Section | Phase 4 | Completed | Abant Izzet Baysal University | 60 | 2023-07-19 | 2023-10-11 |
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Hypotension (26) · Obesity (5) · Pre-Eclampsia (4) · Bradycardia (2) · Diabetes Mellitus, Type 2 (2) · Hip Fractures (2) · Acidosis (1) · Acute Kidney Injury (1) · Atrial Fibrillation (1) · Body Temperature Changes (1) · Brain Ischemia (1) · Brain Neoplasms (1) · Cardiac Output, Low (1) · Cardiovascular Diseases (1) · Cognitive Dysfunction (1)
Ain Shams University (3) · Assiut University (3) · KK Women's and Children's Hospital (3) · B.P. Koirala Institute of Health Sciences (2) · Bayside Health (2) · Beijing Tiantan Hospital (2) · Cairo University (2) · Hopital Charles Nicolle (2) · Hospices Civils de Lyon (2) · Mongi Slim Hospital (2) · Pennington Biomedical Research Center (2) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (2) · University Tunis El Manar (2) · Abant Izzet Baysal University (1) · Air Force Military Medical University, China (1)
Egypt (13) · United States (10) · Tunisia (6) · Turkey (Türkiye) (6) · Canada (5) · China (5) · France (4) · Italy (4) · Denmark (3) · South Korea (3) · Australia (2) · Belgium (2) · Brazil (2) · Nepal (2) · Poland (2)
Mrinalini Balki, MD (2) · Akcan Akkaya, MD. (1) · Alessandro Santini, MD (1) · Alia Jebri, MD (1) · Andrea Cornini, MD (1) · Anis Aribogan, Prof., MD (1) · Antonio Messina (1) · Antonio Monteiro, MD (1) · Antonio Pesenti, MD (1) · Ashraf S Habib, MD (1) · Asish Subedi, MD (1) · Ban L Sng, FANZCA (1) · Ban Leong Sng, FANZCA (1) · Basant E Mohamed, M.B.B.CH (1)
PMID 12439645, PMID 15960713, PMID 16632842, PMID 19228873, PMID 23064293, PMID 23686786, PMID 24256483, PMID 24465046, PMID 24624090, PMID 24905629, PMID 25725625, PMID 26083768, PMID 26272720, PMID 26912506, PMID 28953494, PMID 29046921, PMID 29151054, PMID 29373334, PMID 29415580, PMID 30243062, PMID 31165350, PMID 31684867, PMID 32619039, PMID 33625060, PMID 33661141, PMID 33712076, PMID 33831901, PMID 34002866, PMID 34101716, PMID 36639328, PMID 36703120, PMID 38684243, PMID 41144827, PMID 42370999, PMID 42479502, PMID 42791593
2014 (1), 2019 (1)