20 completed, 8 terminated, 4 recruiting, 4 withdrawn. 19 Phase 2, 10 Phase 1, 9 Phase 3, 7 Phase 4, 2 Not applicable.
Follow Droxidopa: new trials by email Literature Review of Droxidopa trials Research Report on Droxidopa
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease Droxidopa Oral Product, Placebo Control - Menkes Disease | Phase 1 / Phase 2 | Recruiting | Stephen G. Kaler | 6 | 2026-08-10 | 2026-10-05 |
| Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury Droxidopa capsules, Placebo - Acute Kidney Injury, Cirrhosis | Phase 2 | Recruiting | Giuseppe Cullaro, MD | 75 | 2025-05-27 | 2026-08-19 |
| Treatment of Orthostatic Hypotension in SCI Midodrine Hydrochloride - Hypotension | Phase 4 | Recruiting | James J. Peters Veterans Affairs Medical Center | 25 | 2023-07-01 | 2026-08-10 |
| Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism Droxidopa, Placebo Oral Tablet - Parkinson Disease, Multiple System Atrophy | Phase 2 | Withdrawn | Loma Linda University | 2021-12-01 | 2022-03-02 | |
| NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Occipital Horn Syndrome Droxidopa, Placebo - Menkes Disease, Occipital Horn Syndrome | Phase 1 / Phase 2 | Completed | Stephen G. Kaler, MD | 3 | 2021-07-12 | 2026-04-13 |
| Lundbeck TOMs Orthostatic Hypotension Droxidopa 100 MG [Northera] - Orthostatic Hypotension, Idiopathic Parkinson Disease | Phase 4 | Completed | Alberto Espay, MD, MSc | 9 | 2019-02-11 | 2022-09-26 |
| Brain Perfusion & Oxygenation in Parkinson's Disease With NOH Droxidopa, Placebo - Parkinson Disease, Neurogenic Orthostatic Hypotension | Phase 4 | Completed | William Ondo, MD | 17 | 2018-08-23 | 2022-09-06 |
| Effect of L-Dihydroxyphenylserine (L-DOPS) on Falls in Patients With Neurogenic Orthostatic Hypotension (NOH) Droxidopa, Placebo - Parkinson Disease, Falls Patient | Phase 2 | Unknown | St. Joseph's Hospital and Medical Center, Phoenix | 10 | 2018-08-17 | 2019-10-29 |
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury Northera, Placebo - Hypotension, Orthostatic, Hypotension | Phase 4 | Completed | James J. Peters Veterans Affairs Medical Center | 22 | 2018-06-01 | 2025-03-07 |
| Norepinephrine-targeted Therapy for Action Control in Parkinson Disease Droxidopa, Carbidopa - Parkinson Disease | Phase 4 | Completed | Vanderbilt University Medical Center | 15 | 2017-04-18 | 2020-01-27 |
| A Randomized, Double-Blind, Placebo-Controlled Study of Droxidopa for Fatigue in Parkinson's Disease Northera, Placebo Oral Tablet - Parkinson Disease, Fatigue | Phase 4 | Terminated | The Cooper Health System | 1 | 2017-01-01 | 2021-11-23 |
| Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Droxidopa, Midodrine, Placebo - Autonomic Failure, Pure Autonomic Failure | Phase 1 | Recruiting | Vanderbilt University Medical Center | 34 | 2016-09-01 | 2025-10-14 |
| Effect of L-Dihydoxyphenylserine on Locomotion, Postural Stability, and Fall Risk Reduction in Parkinson Disease L-DOPS, Placebo - Parkinson Disease | Phase 2 | Unknown | St. Joseph's Hospital and Medical Center, Phoenix | 20 | 2016-05-01 | 2019-02-15 |
| Effects of Droxidopa When Measuring Gait Speed, Kyphosis, and Functional Reach in Parkinson's Disease droxidopa, Placebo - Parkinson's Disease | Not applicable | Completed | Colorado Springs Neurological Associates | 21 | 2016-04-01 | 2018-06-25 |
| Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Droxidopa capsules, Placebo capsules - Symptomatic Neurogenic Orthostatic Hypotension | Phase 4 | Completed | H. Lundbeck A/S | 453 | 2016-02-11 | 2023-08-23 |
| A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Droxidopa (L-DOPS), Placebo - HSAN Type IV | Phase 2 | Withdrawn | NYU Langone Health | 2016-01-01 | 2016-09-12 | |
| Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS) Northera (Droxidopa), Placebo - Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS) | Phase 2 | Terminated | New York Medical College | 30 | 2015-09-01 | 2025-05-23 |
| Study to Assess the Clinical Benefit and Safety of Droxidopa in Parkinson's Disease Droxidopa, sugar pill - Parkinson's Disease, Freezing of Gait | Phase 2 | Unknown | Henry Ford Health System | 20 | 2015-03-01 | 2016-11-03 |
| Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA L-Threo DOPS, placebo - Multiple System Atrophy | Phase 2 / Phase 3 | Completed | University Hospital, Toulouse | 107 | 2014-01-21 | 2026-04-08 |
| A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy Droxidopa, Placebo - Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease | Phase 3 | Terminated | Chelsea Therapeutics | 61 | 2013-11-01 | 2016-01-08 |
Showing 20 of 41. Sign in to see all of them.
Hypotension, Orthostatic (14) · Parkinson Disease (14) · Multiple System Atrophy (8) · dopamine beta hydroxylase deficiency (7) · Pure Autonomic Failure (6) · Autonomic Nervous System Diseases (4) · Fatigue (3) · Hypotension (3) · Orthostatic Intolerance (3) · Dizziness (2) · Menkes Kinky Hair Syndrome (2) · Postural Orthostatic Tachycardia Syndrome (2) · Spinal Cord Injuries (2) · Acute Kidney Injury (1) · Asthenia (1)
Chelsea Therapeutics (14) · James J. Peters Veterans Affairs Medical Center (2) · St. Joseph's Hospital and Medical Center, Phoenix (2) · Vanderbilt University (2) · Vanderbilt University Medical Center (2) · Alberto Espay, MD, MSc (1) · Beth Israel Deaconess Medical Center (1) · Bronx VA Medical Center (1) · Colorado Springs Neurological Associates (1) · Giuseppe Cullaro, MD (1) · H. Lundbeck A/S (1) · Henry Ford Health System (1) · Icahn School of Medicine at Mount Sinai (1) · Loma Linda University (1) · Mayo Clinic (1)
United States (36) · Canada (4) · Australia (2) · New Zealand (2) · France (1) · Taiwan (1) · United Kingdom (1)
Horacio Kaufmann, MD (3) · Abraham Lieberman, MD (2) · Roy Freeman, MD (2) · Alberto Vasquez, MD (1) · Alvin McElveen, MD (1) · Andrew McGarry, MD (1) · Brent Goodman, MD (1) · Charles W Lapp, M.D. (1) · Christen Kutz, PhD, PA-C (1) · Christopher J Mathias, MD (1) · Christopher J. Mathias, MD (1) · David Robertson, M.D. (1) · David Robertson, MD (1) · David S Goldstein, M.D. (1)
PMID 27538531, PMID 28494751, PMID 12885750, PMID 15666063, PMID 24326693, PMID 25350981, PMID 25907673, PMID 29392574, PMID 30003579, PMID 35107750, PMID 41269291, PMID 42016919
P01HL056693 (1), P01NS044233 (1), R01HL059459 (1)