513 completed, 233 unknown, 112 recruiting, 80 not yet recruiting. 295 Not applicable, 147 Phase 2, 132 Phase 3, 81 Phase 4, 41 Phase 1.
Follow Shock, Septic: new trials by email Literature Review of Shock, Septic trials Research Report on Shock, Septic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis Vasopressors, Fluids - Septic Shock, Fluid Resuscitation | Not yet recruiting | Australian and New Zealand Intensive Care Research Centre | 7838 | 2027-11-01 | 2026-11-09 | |
| Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU Extended beta-lactam antibiotics, Intermittent Beta-lactam antibiotics - Sepsis, Septic Shock | Not yet recruiting | Assiut University | 90 | 2027-10-01 | 2026-09-01 | |
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| Biological Effects of Hemoadsorption in Septic Shock Hemoadsorption cartridge - Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction | Not applicable | Not yet recruiting | Miguel Sanchez Garcia | 16 | 2027-01-07 | 2026-07-20 |
| Remote Ischemic Postconditioning in Septic Shock Remote ischemic conditioning, No intervention - Adult Patients With Septic Shock Admitted in Intensive Care Unit | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 720 | 2027-01-01 | 2026-10-09 |
| Immune Dysregulation During Sepsis: A Natural History Cohort Sepsis, Septic Shock | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 500 | 2027-01-01 | 2026-10-09 | |
| Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial Vitamin C, Standard of Care (SOC) - Acute-on-Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 110 | 2026-12-15 | 2026-11-06 |
| Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis Sepsis, Severe Sepsis | Not yet recruiting | The University of Texas Health Science Center, Houston | 30 | 2026-12-01 | 2025-06-11 | |
| AI-ECHO Hemodynamic Phenotyping in Septic Shock Point-of-care echocardiography - Sepsis, Septic Shock | Not yet recruiting | Second Affiliated Hospital of Guangzhou Medical University | 240 | 2026-11-30 | 2026-11-09 | |
| ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers ICU-SUCCEED, Augmented Usual Care - Acute Respiratory Failure, Critical Illness | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 144 | 2026-11-15 | 2026-11-05 |
| Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit 13C6-Glucose - Glucose, Metabolism | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 25 | 2026-11-01 | 2026-09-09 |
| Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic Shock Septic Shock, Sepsis | Not yet recruiting | Assiut University | 54 | 2026-11-01 | 2026-10-13 | |
| Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples InfectID-BSI (Bloodstream Infection) qPCR Assay - Bloodstream Infection, Sepsis | Not yet recruiting | Microbio Co Ltd | 1500 | 2026-11-01 | 2026-10-08 | |
| Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 78 | 2026-11-01 | 2026-09-24 |
| Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational Study Sepsis | Recruiting | Sir Run Run Shaw Hospital | 3000 | 2026-11-01 | 2026-10-28 | |
| Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in Sepsis Serum GDF-15 and LGALS3BP Measurement - Sepsis, Septic Shock | Not yet recruiting | Inonu University | 150 | 2026-11-01 | 2026-10-30 | |
| Neutrophil Activation and NETosis in Sepsis Sepsis, Septic Shock | Not yet recruiting | Assiut University | 85 | 2026-10-20 | 2026-10-22 | |
| A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily, Placebo - Septic Shock | Phase 3 | Recruiting | The George Institute | 2200 | 2026-10-16 | 2026-10-30 |
| Sepsis ICU Gut Microbiome Analysis Naturally Occurring Exposures - Sepsis, Septic Shock | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 180 | 2026-10-15 | 2026-10-08 | |
| Myeloid Bias in the Bone Marrow of Septic Patients and Its Correlation With Disease Severity and Prognosis: A Single-Center, Prospective Cohort Study Bone marrow aspirate collection - Sepsis, Septic Shock | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 45 | 2026-10-15 | 2026-09-24 |
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Sepsis (548) · Critical Illness (62) · Acute Kidney Injury (54) · Shock (44) · Multiple Organ Failure (35) · Infections (34) · Systemic Inflammatory Response Syndrome (34) · Respiratory Distress Syndrome (24) · Diabetes Insipidus (21) · Emergencies (15) · Inflammation (15) · Hypotension (14) · Bacteremia (13) · Shock, Cardiogenic (13)
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PMID 26903338, PMID 28101605, PMID 11445675, PMID 11794169, PMID 21516036, PMID 23353941, PMID 25392034, PMID 28343448, PMID 29784057, PMID 32520577, PMID 34519356, PMID 34605781, PMID 36416787, PMID 39716214, PMID 11588440, PMID 12500513, PMID 12519925, PMID 12720570, PMID 16134766, PMID 16424713, PMID 17334251, PMID 18533029, PMID 19531784, PMID 19926252, PMID 20179283, PMID 21615299, PMID 21669950, PMID 22073193, PMID 23001587, PMID 23067578, PMID 23512062, PMID 23525934, PMID 23740148, PMID 23899564, PMID 23963131, PMID 23984731, PMID 24401721, PMID 24484547, PMID 24635770, PMID 24635772, PMID 24794878, PMID 25272316, PMID 25286986, PMID 25887027, PMID 26414292, PMID 26771781, PMID 26903335, PMID 26903336, PMID 27296693, PMID 27406647
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