121 completed, 51 unknown, 31 recruiting, 14 terminated. 96 Not applicable, 66 Phase 4, 38 Phase 3, 18 Phase 2, 8 Phase 1.
Follow Norepinephrine: new trials by email Literature Review of Norepinephrine trials Research Report on Norepinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ED90 of Norepinephrine and Phenylephrine Infusion in Patients of Advanced Maternal Age Norepinephrine, Phenylephrine - Adverse Event, Hypotension (MeSH: D007022) | Not applicable | Not yet recruiting | General Hospital of Ningxia Medical University | 60 | 2027-01-31 | 2026-10-26 |
| OB VEGA-Phenylephrine vs Norepinephrine Outcomes Phenylephrine, Norepinephrine - Hypotension During Surgery, Cesarean Birth | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 1500 | 2027-01-01 | 2026-10-28 |
| Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 78 | 2026-11-01 | 2026-09-24 |
| Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) Dopamine administration, Norepinephrine - Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN) | Phase 4 | Recruiting | University of California, Davis | 30 | 2026-10-30 | 2026-08-18 |
| Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary Surgery Conventional Fluid Therapy, Low-Dose Norepinephrine, Conservative Goal-Directed Fluid Therapy - Postoperative Complications, Pulmonary Complication | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-20 | 2026-10-23 |
| Pre-induction Norepinephrine in Septic Patients Undergoing Surgery Norepinephrine, Standard Care - Sepsis, Hypotension | Not applicable | Not yet recruiting | Assiut University | 90 | 2026-10-10 | 2026-10-15 |
| Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock Hemodynamic measurements during reduction in Norepinephrine and fluid boli. - Acute Kidney Injury Due to Sepsis | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-10-28 |
| Vasopressor Agents in Pulmonary Hypertension Crisis Norepinephrine, Dopamine, Epinephrine - Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | Not applicable | Recruiting | China National Center for Cardiovascular Diseases | 75 | 2026-08-19 | 2026-10-30 |
| 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery Norepinephrine 10 mcg, Norepinephrine 5 mcg - Hypotension on Induction, Emergency Surgery | Not applicable | Recruiting | Cairo University | 136 | 2026-08-04 | 2026-08-05 |
| Effect of Vasopressin Versus Norepinephrine on Post-operative Mean Pulmonary Arterial Pressure Following Pulmonary Endarterectomy Surgery, Vasopressin, Norepinephrine - Anesthesia, Pulmonary Hypertension | Phase 2 | Not yet recruiting | Fondation Hôpital Saint-Joseph | 90 | 2026-08-01 | 2026-06-02 |
| PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery Norepinephrine, Placebo - Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs) | Not applicable | Not yet recruiting | Suez Canal University | 130 | 2026-07-15 | 2026-07-13 |
| Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic Shock Norepinephrine, Dopamine Agent - Cardiogenic Shock | Not applicable | Recruiting | Chonnam National University Hospital | 512 | 2026-06-16 | 2026-10-15 |
| Phenotype Guided Vasoactive Medication During Kidney Transplantation Phenotype-Guided Vasoactive Management - Kidney Transplant, Fluid Management | Phase 4 | Enrolling by invitation | Jennifer Cutler | 255 | 2026-06-01 | 2026-10-22 |
| Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension Norepinephrine, Phenylephrine - Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients | Phase 4 | Recruiting | Sohag University | 62 | 2026-05-22 | 2026-06-23 |
| Early Co-Administration of Crystalloid Fluid and Norepinephrine for Preventing Acute Kidney Injury in Septic Shock Norepinephrine, Crystalloid Fluid Resuscitation - Septic Shock, Acute Kidney Injury | Not applicable | Not yet recruiting | Universitas Sumatera Utara | 100 | 2026-04-23 | 2026-02-18 |
| Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis Norepinephrine (0.05 μg/kg/min), Placebo - Secondary Peritonitis, Post-induction Hypotension | Phase 4 | Not yet recruiting | Bach Mai Hospital | 60 | 2026-04-01 | 2026-04-14 |
| Evaluation of the Argos System to Estimate Cardiac Output Fluid bolus, Norepinephrine - Shock | Recruiting | Bicetre Hospital | 120 | 2026-02-01 | 2026-07-24 | |
| Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension Induced hypertension with norepinephrine, Endoluminal Spasmolysis - Subarachnoid Aneurysm Hemorrhage, Cerebral Vasospasm After Subarachnoid Hemorrhage | Recruiting | Region Stockholm | 200 | 2025-12-01 | 2025-12-26 | |
| Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal Anesthesia Norepinephrine, Ephedrine - Cesarean Delivery Affecting Newborn, Acidosis | Phase 4 | Completed | mehmet özkılıç | 155 | 2025-09-01 | 2026-10-08 |
| Comparing Two Different Norepinephrine Infusion Rates for Prophylaxis Against Spinal-induced Hypotension in Elderly Norepinephrine (0.1 μg/kg/min), Norepinephrine (0.07 μg/kg/min) - Spinal Aneshtesia, Hypotension After Spinal Anesthesia | Not applicable | Completed | Kasr El Aini Hospital | 84 | 2025-08-01 | 2026-03-24 |
Showing 20 of 241. Sign in to see all of them.
Hypotension (52) · Shock, Septic (34) · Sepsis (20) · Shock (15) · Acute Kidney Injury (12) · Diabetes Insipidus (12) · Pre-Eclampsia (6) · Hypertension (5) · Postoperative Complications (5) · Cardiovascular Diseases (4) · Critical Illness (4) · Vasoplegia (4) · Aneurysm (3) · Head and Neck Neoplasms (3) · Hypertension, Pulmonary (3)
General Hospital of Ningxia Medical University (18) · Cairo University (12) · Assiut University (7) · Kasr El Aini Hospital (6) · Sahlgrenska University Hospital (6) · Tanta University (5) · Centre Hospitalier Universitaire, Amiens (4) · Institute of Liver and Biliary Sciences, India (4) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (4) · Brigham and Women's Hospital (3) · ProCertus BioPharm, Inc (3) · University Tunis El Manar (3) · University of Sao Paulo (3) · Ain Shams University (2) · Algemeen Ziekenhuis Maria Middelares (2)
United States (36) · Egypt (34) · China (32) · France (18) · Canada (11) · Sweden (10) · Brazil (9) · Turkey (Türkiye) (7) · Belgium (6) · India (6) · Italy (6) · South Korea (6) · Tunisia (6) · Netherlands (5) · United Kingdom (5)
Yi Chen, M.D. (12) · Xinli Ni, Dr. (5) · Ahmed Mukhtar, Professor (4) · Sven-Erik Ricksten, Professor (3) · Andreas Nygren, MD PHD (2) · Eric Bellissant, MD, PhD (2) · Gordon H Williams, MD (2) · Mrinalini Balki, MD (2) · Sean van Diepen, MD, MSc (2) · Ahlem Trifi (1) · Ahmed Hasanin, Professor (1) · Ahmed M Hasanin, Professor (1) · Ahmed M Mukhtar, MD (1) · Ahmed M Mukhtar, Professor (1)
PMID 18305265, PMID 27483065, PMID 27841822, PMID 28973220, PMID 29600824, PMID 29784057, PMID 31461138, PMID 32303180, PMID 34605781, PMID 36279409, PMID 38869701, PMID 11529214, PMID 11555538, PMID 12519925, PMID 12794416, PMID 14980943, PMID 15028145, PMID 15716709, PMID 15960713, PMID 16010055, PMID 16174954, PMID 16192766, PMID 16507156, PMID 16545046, PMID 16616623, PMID 16865783, PMID 16879732, PMID 17099041, PMID 17560680, PMID 17720019, PMID 18212647, PMID 18564410, PMID 19017409, PMID 19534818, PMID 19664253, PMID 19841897, PMID 19851126, PMID 19926252, PMID 20156348, PMID 20486907, PMID 20725823, PMID 21045639, PMID 21615299, PMID 21705869, PMID 21772125, PMID 22307074, PMID 22518026, PMID 22906292, PMID 22929242, PMID 23091606
2008 (1), 2014 (1), 2017 (1), 2018 (1), 2019 (1), 2023 (1), 2025 (1), K01HL148144 (1), R01DK139484 (1), R01HL104032 (1), R01HL177834 (1), UL1RR024975-01 (1), UL1TR000445-06 (1)