274 completed, 45 unknown, 29 terminated, 16 recruiting. 100 Phase 4, 86 Not applicable, 86 Phase 2, 73 Phase 3, 55 Phase 1.
Follow Ondansetron: new trials by email Literature Review of Ondansetron trials Research Report on Ondansetron
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera Ondansetron, Standard Cholera Care - Cholera (Disorder) | Phase 2 | Not yet recruiting | Public Interest Science Center | 120 | 2026-10-20 | 2026-10-19 |
| Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in Preeclampsia Dexamethasone, Ondansetron - Preeclampsia, Spinal Anesthesia-Induced Hypotension | Phase 4 | Not yet recruiting | Assiut University | 110 | 2026-10-01 | 2026-08-31 |
| Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT Ondansetron hydrochloride 8 mg IV Q8H, 0.9 % Normal Saline 10 ml - ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation | Phase 2 / Phase 3 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 76 | 2026-10-01 | 2026-05-14 |
| Effects of Ondansetron Timing During Spinal Anesthesia for Urologic Surgery Ondansetron 8 mg, 0.9 % sodium chloride - Spinal Anesthesia-Induced Hypotension, Cerebral Oxygenation | Phase 4 | Not yet recruiting | Istanbul University | 99 | 2026-09-30 | 2026-10-19 |
| Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers KarXT, Trimethobenzamide, Ondansetron - Healthy Volunteers | Phase 4 | Recruiting | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 180 | 2026-09-03 | 2026-10-15 |
| Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg - Postoperative Nausea and Vomiting | Phase 4 | Recruiting | Faisalabad Medical University | 264 | 2026-09-01 | 2026-09-04 |
| A Simplified Regimen to Prevent Nausea and Vomiting Using Netupitant/Palonosetron in Germ Cell Cancer Patients Receiving Chemotherapy Netupitant/Palonosetron Hydrochloride, Ondansetron (Control), Aprepitant - Germ Cell Cancer | Early Phase 1 | Not yet recruiting | Ottawa Hospital Research Institute | 10 | 2026-08-01 | 2026-06-23 |
| Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia Ondansetron 4mg, metoclopramide - Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia | Phase 4 | Recruiting | Sanliurfa Education and Research Hospital | 120 | 2026-07-30 | 2026-10-01 |
| Acupoint Application for Chemotherapy-Induced Nausea and Vomiting in Lung Cancer 5-HT3 receptor antagonist (e.g., ondansetron), Acupoint application - Lung Cancer (Diagnosis)Chemotherapy-Induced Nausea and Vomiting | Not applicable | Recruiting | Xiu Huang | 60 | 2026-07-15 | 2026-08-17 |
| Aprepitant to Improve Same Day Discharge for TKA Aprepitant Injection, Ondansetron (Zofran), Dexamethasone - PONV | Phase 4 | Not yet recruiting | Endeavor Health | 350 | 2026-07-01 | 2026-06-10 |
| Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection. Group C (Control), Ondansetron 8 mg, Lidocaine %2 ampoule - Anesthesia Induction, Propofol Pain Injection | Not applicable | Not yet recruiting | Mongi Slim Hospital | 156 | 2026-06-08 | 2026-06-08 |
| The Safety and Efficacy of Ondansetron in Reducing Immune Checkpoint Inhibitor-Related Toxicities ondansetron - Hepatocellular Carcinoma (HCC), IrAE | Phase 2 | Recruiting | First Affiliated Hospital of Wenzhou Medical University | 134 | 2026-04-30 | 2026-08-04 |
| Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section Ondansetron, Placebo (0.9% Sodium Chloride) - Hypotension, Spinal Anesthesia | Phase 4 | Completed | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 96 | 2026-02-02 | 2026-10-21 |
| Post Operative Shivering Following Anesthesia Dexmedetomidin, Mg (magnesium sulfate), Ondansetron 8 mg - Shivering, Spinal Anesthesia | Not applicable | Not yet recruiting | Sohag University | 60 | 2026-02-01 | 2026-02-04 |
| Midazolam Adjunct Therapy for Prevention of PONV in Gynecological Laparoscopy Midazolam 0.05 mg/kg IV as adjunct to dexamethasone and ondansetron for PONV prevention - Postoperative Nausea and Vomiting (PONV), Gynecological Laparoscopic Surgery | Phase 2 | Completed | Hameed Latif Hospital, Lahore | 300 | 2025-12-02 | 2026-06-25 |
| Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy Ondansetron Intraperitoneal Lavage, Saline Intraperitoneal Lavage - Postoperative Pain Management, Laparoscopic Cholecystectomy | Phase 4 | Active not recruiting | Instituto Mexicano del Seguro Social | 40 | 2025-12-01 | 2025-12-16 |
| Nano-crystalline Megestrol Acetate for Chemotherapy-induced Nausea and Vomiting nanocrystalline megestrol acetate combined with ondansetron, dexamethasone combined with ondansetron - Chemotherapy-Induced Nausea and Vomiting (CINV) | Phase 2 | Not yet recruiting | AIPING ZHOU | 127 | 2025-12-01 | 2025-11-24 |
| Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients Ondansetron (Zofran), chewing gum, Ondansetron + Chewing gum - Postoperative Nausea and Vomiting (PONV) | Phase 1 | Active not recruiting | Makassed General Hospital | 90 | 2025-08-22 | 2025-10-01 |
| Oral Ondansetron to Improve Patient Experience of Unsedated Esophagogastroduodenoscopy Pilot Study ondansetron and dyclonine hydrochloride, dyclonine hydrochloride only - Esophagogastroduodensocopy (EGD) Procedure | Phase 4 | Active not recruiting | Peking Union Medical College Hospital | 40 | 2025-07-01 | 2026-05-01 |
| Clinical Trial to Investigate the Efficacy and Safety of Ondansetron (Danset - Adwia) Versus Placebo Plus the Standard of Care in the Treatment of Nausea and Vomiting in Adult Patients With Acute Gastroenteritis Ondansetron 8 mg ampoule, Metoclopramide 10 mg ampoule - Gastroenteritis | Phase 3 | Unknown | Genuine Research Center, Egypt | 126 | 2025-06-01 | 2024-09-26 |
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Vomiting (116) · Nausea (82) · Postoperative Nausea and Vomiting (69) · Pain, Postoperative (16) · Alcoholism (14) · Neoplasms (14) · Hypotension (13) · Gastroenteritis (9) · Pain (9) · Lymphoma, Non-Hodgkin (8) · Leukemia, Myeloid, Acute (7) · Agnosia (6) · Breast Neoplasms (6) · Multiple Myeloma (6) · Schizophrenia (6)
Merck Sharp & Dohme LLC (17) · GlaxoSmithKline (8) · Assiut University (7) · M.D. Anderson Cancer Center (6) · Stanford University (6) · Duke University (5) · National Cancer Institute (NCI) (5) · Tanta University (5) · University of British Columbia (5) · University of Virginia (5) · Emory University (4) · Mylan Pharmaceuticals Inc (4) · Par Pharmaceutical, Inc. (4) · University of Calgary (4) · University of Colorado, Denver (4)
United States (162) · Canada (37) · Egypt (22) · India (15) · Pakistan (15) · China (14) · Turkey (Türkiye) (14) · South Korea (12) · Italy (10) · United Kingdom (10) · Czechia (8) · Denmark (8) · France (8) · Poland (8) · Thailand (8)
Bankole Johnson, DSc, MD, PhD (3) · Christian Aumais (3) · Eric Sicard, M.D. (3) · Gary R. Morrow, PhD, MS (3) · Robin Spiller (3) · Simon Haroutounian, PhD (3) · Stephen Freedman, MD (3) · Bankole Johnson, DSc,MD,PhD (2) · Dorian Williams, M.D. (2) · Dr. I.S Gandhi (2) · Dr. Tarang Shah, M.D. (2)
PMID 21079721, PMID 25770814, PMID 10227938, PMID 10433490, PMID 10718794, PMID 11028830, PMID 11226762, PMID 11266262, PMID 11273930, PMID 11474424, PMID 11535479, PMID 11772809, PMID 11812709, PMID 11826129, PMID 12067003, PMID 12598264, PMID 12686700, PMID 12697943, PMID 12764341, PMID 12768180, PMID 12906958, PMID 1352024, PMID 14570668, PMID 14574212, PMID 14633551, PMID 15107371, PMID 15139073, PMID 15189396, PMID 1531705, PMID 1535245, PMID 16000093, PMID 1609990, PMID 16198982, PMID 16464423, PMID 16580905, PMID 16717343, PMID 16766588, PMID 16849762, PMID 16916674, PMID 17054284, PMID 17157685, PMID 17187507, PMID 17263269, PMID 17285386, PMID 17530482, PMID 17959952, PMID 18006188, PMID 18073548, PMID 18158814, PMID 18304050
2008 (3), 2009 (2), 2014 (2), R01AA010522 (2), 1RC2DA028905-01 (1), 2015 (1), P01DK068055 (1), P50AA010761 (1), R01AA012964 (1), R01AA013964 (1), R01AA018896 (1), R01DA021776 (1), R01DA029078 (1), R01DE005215 (1), R01GM123330 (1)