Pure Autonomic Failure: Clinical Trials

56 trials for Pure Autonomic Failure, newest first

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

31 completed, 10 terminated, 9 recruiting, 2 unknown. 17 Not applicable, 9 Phase 1, 8 Phase 3, 6 Phase 2, 3 Early Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	17	Completed 10, Recruiting 7
Phase 1	9	Completed 5, Terminated 2, Recruiting 1, Withdrawn 1
Phase 3	8	Completed 5, Terminated 3
Phase 2	6	Completed 3, Active not recruiting 1, Terminated 1, Unknown 1
Early Phase 1	3	Terminated 2, Completed 1
Phase 4	1	Completed 1

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Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Epidural Electrical Stimulation to Support Hemodynamic Management in Individuals With Parkinson's Disease ARC-IM Investigational System - Hypotension Symptomatic, Parkinson's Disease	Not applicable	Recruiting	Ecole Polytechnique Fédérale de Lausanne	5	2025-07-03	2026-07-07
CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study CO2 ReHaler - Neurogenic Orthostatic Hypotension, Autonomic Failure	Not applicable	Recruiting	University of Calgary	28	2024-07-30	2026-05-05
Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System Polyneuropathy, Alpha-Synucleinopathy		Enrolling by invitation	University of Aarhus	100	2024-05-13	2025-01-08
CPAP for the Treatment of Supine Hypertension Active CPAP, Sham CPAP, Sleeping in a head-up tilt (HUT) position - Autonomic Failure, Pure Autonomic Failure	Not applicable	Recruiting	Vanderbilt University Medical Center	59	2022-06-23	2026-04-07
A Study of Lu AF82422 in Participants With Multiple System Atrophy Lu AF82422, Placebo - Multiple System Atrophy	Phase 2	Active not recruiting	H. Lundbeck A/S	64	2021-11-16	2026-04-13
Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms Accelerometer, placebo pill, Midodrine or atomoxetine pill - Orthostatic; Hypotension, Neurogenic, Autonomic Failure	Not applicable	Recruiting	Vanderbilt University Medical Center	29	2021-02-05	2026-07-02
Synuclein-One Study Skin Biopsy - Parkinson Disease, Multiple System Atrophy		Completed	CND Life Sciences	428	2021-01-04	2024-01-03
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients Midodrine, Placebo pill, Abdominal compression - Neurogenic Orthostatic Hypotension, Autonomic Failure	Early Phase 1	Completed	Vanderbilt University Medical Center	31	2020-11-09	2026-08-07
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure Tilt, Elevated trunk, Tilt - In home - Supine Hypertension, Autonomic Failure	Not applicable	Recruiting	Vanderbilt University Medical Center	44	2020-08-21	2026-10-22
[18F]F-DOPA Imaging in Patients With Autonomic Failure [18F]FDOPA, Carbidopa 200mg oral dose, Entacapone 400mg oral dose - Autonomic Failure, Pure Autonomic Failure	Phase 1	Recruiting	Daniel Claassen	40	2020-02-04	2026-03-16
Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure ampreloxetine - Symptomatic Neurogenic Orthostatic Hypotension	Phase 3	Terminated	Theravance Biopharma	110	2019-09-19	2022-11-30
Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure ampreloxetine, Placebo - Symptomatic Neurogenic Orthostatic Hypotension, MSA	Phase 3	Terminated	Theravance Biopharma	203	2019-02-22	2023-01-20
Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure ampreloxetine, Placebo - Symptomatic Neurogenic Orthostatic Hypotension	Phase 3	Completed	Theravance Biopharma	195	2019-01-24	2022-09-14
Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy Deep brain stimulation - Multiple System Atrophy, Autonomic Failure	Not applicable	Completed	University of Oxford	5	2018-09-09	2022-11-02
Clinical Laboratory Evaluation of Chronic Autonomic Failure 13N-Ammonia, 18F-DOPA, 11C-Methylreboxetine (11C-MRB) - Parkinson's Disease, Multiple System Atrophy		Completed	National Institute of Neurological Disorders and Stroke (NINDS)	89	2018-09-06	2026-10-26
Automated Abdominal Binder for Orthostatic Hypotension automated abdominal binder, Sham binder, Placebo - Orthostatic Hypotension, Autonomic Failure	Phase 1 / Phase 2	Completed	Vanderbilt University Medical Center	28	2018-03-01	2026-05-05
Treatment of Supine Hypertension in Autonomic Failure (CPAP) continuous positive airway pressure (CPAP), Placebo - Supine Hypertension, Autonomic Failure	Not applicable	Recruiting	Vanderbilt University Medical Center	12	2017-09-21	2025-11-06
TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) TD-9855, Placebo - Neurogenic Orthostatic Hypotension, Multiple System Atrophy (MSA) With Orthostatic Hypotension	Phase 2	Completed	Theravance Biopharma	34	2017-09-09	2022-09-26
Concentration and Attentional Deficits in POTS and Other Autonomic Neuropathies leg crossing - Autonomic Failure, Dysautonomia	Not applicable	Completed	RWTH Aachen University	110	2017-04-01	2023-06-26
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension Heating pad, Sham control - Hypertension, Pure Autonomic Failure	Not applicable	Recruiting	Vanderbilt University Medical Center	20	2017-01-30	2026-01-16

Pure Autonomic Failure: Clinical Trials

56 trials for Pure Autonomic Failure, newest first

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

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