118 completed, 29 unknown, 18 terminated, 17 recruiting. 68 Not applicable, 57 Phase 4, 28 Phase 3, 22 Phase 2, 11 Phase 1.
Follow Phenylephrine: new trials by email Literature Review of Phenylephrine trials Research Report on Phenylephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ED90 of Norepinephrine and Phenylephrine Infusion in Patients of Advanced Maternal Age Norepinephrine, Phenylephrine - Adverse Event, Hypotension (MeSH: D007022) | Not applicable | Not yet recruiting | General Hospital of Ningxia Medical University | 60 | 2027-01-31 | 2026-10-26 |
| OB VEGA-Phenylephrine vs Norepinephrine Outcomes Phenylephrine, Norepinephrine - Hypotension During Surgery, Cesarean Birth | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 1500 | 2027-01-01 | 2026-10-28 |
| Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension Norepinephrine, Phenylephrine - Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients | Phase 4 | Recruiting | Sohag University | 62 | 2026-05-22 | 2026-06-23 |
| Clinical Study of DA-001 as a Treatment for Hair Shedding Reduction and Hair Re-Growth DA-001, Placebo, Phenylephrine - Telogen Effluvium, Female Pattern Hair Loss | Phase 2 / Phase 3 | Not yet recruiting | Applied Biology, Inc. | 1120 | 2026-05-01 | 2026-04-13 |
| Effect of Continuous Phenylephrine Infusion on Preventing Shivering After Spinal Anesthesia in Cesarean Section Phenylephrine - Shivering Caused by Spinal Anesthesia | Not applicable | Completed | Universitas Indonesia | 108 | 2026-04-07 | 2026-10-06 |
| Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension. Norepinephrine, Phenylephrine - Outcome | Not applicable | Completed | General Hospital of Ningxia Medical University | 700 | 2025-08-01 | 2026-04-28 |
| ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment in Preeclamptic Patients Norepinephrine, Phenylephrine - Adverse Effect | Not applicable | Unknown | General Hospital of Ningxia Medical University | 80 | 2025-07-01 | 2023-12-06 |
| 90% Effective Dose of Phenylephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients Alpha-Agonist, α-adrenergic receptor agonist - Adverse Effect | Not applicable | Unknown | General Hospital of Ningxia Medical University | 80 | 2025-07-01 | 2023-11-30 |
| Pharmacokinetic Study of Topical Phenylephrine Phenylephrine - Chemotherapy Induced Alopecia, Chemotherapy Side Effects | Early Phase 1 | Recruiting | Applied Biology, Inc. | 24 | 2025-06-30 | 2025-10-03 |
| The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery Norepinephrine, Phenylephrine - Anesthesia, Surgery With General Anesthesia | Phase 4 | Recruiting | University of California, San Francisco | 18000 | 2025-04-01 | 2026-05-26 |
| ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment Norepinephrine, Phenylephrine - Adverse Effect | Not applicable | Unknown | General Hospital of Ningxia Medical University | 80 | 2025-04-01 | 2023-12-06 |
| Phase 3 Clinical Trial to Evaluate Paracetamol /Fexofenadine /Phenylephrine in Flu and Cold Treatment Experimental drug (paracetamol 500mg / fexofenadine 60mg / phenylephrine 20mg), Placebo - Cold, Flu Symptom | Phase 3 | Completed | Eurofarma Laboratorios S.A. | 567 | 2025-03-26 | 2026-10-26 |
| Norepinephrine vs. Phenylephrine for Spinal Hypotension in Cesarean Section Norepinephrine 4mcg, Phenylephrine 50 mcg - Hypotenstion, Cesarean Resection | Not applicable | Completed | Universitas Sumatera Utara | 46 | 2025-02-07 | 2025-09-04 |
| CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN carbogen with or without phenyleprhine, phenylephrine - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Yonsei University | 40 | 2025-02-01 | 2025-01-20 |
| ED90 of Norepinephrine and Phenylephrine Infusions Under Intensive Treatment Norepinephrine, Phenylephrine - Adverse Effect | Not applicable | Completed | General Hospital of Ningxia Medical University | 60 | 2025-01-01 | 2025-05-25 |
| Ephedrine Versus Phenylephrine for Spinal Block - Related Hypotension in Cesarean Delivery Ephedrine, Phenylephrine - Spinal Anesthesia, Cesarean Delivery | Completed | Centre of Postgraduate Medical Education | 94 | 2024-12-16 | 2025-09-19 | |
| ED90 of Norepinephrine and Phenylephrine Infusions in Preeclamptic Patients Norepinephrine, Phenylephrine - Adverse Effect | Not applicable | Completed | General Hospital of Ningxia Medical University | 60 | 2024-10-03 | 2025-10-06 |
| Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2) BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil) - Acute Ischemic Stroke | Phase 3 | Recruiting | Yonsei University | 176 | 2024-10-01 | 2026-02-13 |
| Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold Acetylcysteine, Paracetamol, Phenylephrine - Common Cold | Phase 3 | Withdrawn | Sandoz | 2024-09-20 | 2024-09-26 | |
| Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION） Norepinephrine or phenylephrine - Tumor, Stroke | Not applicable | Recruiting | Zhejiang Cancer Hospital | 214 | 2024-09-18 | 2024-12-02 |
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Hypotension (46) · Mydriasis (10) · Pre-Eclampsia (8) · Common Cold (6) · Ischemic Stroke (6) · Aneurysm (5) · Cardiovascular Diseases (5) · Shock, Septic (5) · Acute Kidney Injury (4) · Cardiac Output, Low (3) · Cataract (3) · Diabetes Insipidus (3) · Drug-Related Side Effects and Adverse Reactions (3) · Orthostatic Intolerance (3) · Postural Orthostatic Tachycardia Syndrome (3)
General Hospital of Ningxia Medical University (13) · Medical University of Vienna (6) · Cairo University (5) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (5) · Seoul National University Hospital (4) · University of Alberta (4) · Vanderbilt University Medical Center (4) · Applied Biology, Inc. (3) · Assiut University (3) · Bayer (3) · KK Women's and Children's Hospital (3) · Khon Kaen University (3) · University of California, San Francisco (3) · Wake Forest University Health Sciences (3) · Yonsei University (3)
United States (49) · Canada (17) · China (17) · Egypt (14) · South Korea (11) · Austria (6) · Belgium (5) · Brazil (5) · Netherlands (5) · Denmark (4) · France (4) · Italy (4) · Greece (3) · Norway (3) · Thailand (3)
Yi Chen, M.D. (8) · Sean van Diepen, MD, MSc (4) · Xinli Ni, Dr. (4) · Ahmed Mukhtar, Professor (3) · Craig Steinback, PhD (3) · Yosanan Yospaiboon, M.D. (3) · Alain F Kalmar, MD, PhD (2) · Andy Goren, MD (2) · Gabriele Fuchsjaeger-Mayrl, MD, Univ.Doz. (2) · Mrinalini Balki, MD (2) · Ahmed M Mukhtar, Professor (1) · Alain Kalmar, Dr (1) · Alessandro Santini, MD (1)
PMID 24624090, PMID 29090733, PMID 10839257, PMID 11916798, PMID 12145033, PMID 16311286, PMID 17205877, PMID 17215703, PMID 18657662, PMID 18946298, PMID 19017409, PMID 19230461, PMID 19374211, PMID 19716536, PMID 19859776, PMID 20462091, PMID 20495139, PMID 20627878, PMID 22368443, PMID 22759268, PMID 22798273, PMID 22821620, PMID 23399717, PMID 23439596, PMID 23835589, PMID 23837606, PMID 24256483, PMID 24920942, PMID 25421140, PMID 25635593, PMID 26083768, PMID 26560899, PMID 26994228, PMID 27020488, PMID 27089938, PMID 27144689, PMID 27601104, PMID 27733286, PMID 27778639, PMID 28235526, PMID 28244952, PMID 28953494, PMID 29151054, PMID 29162132, PMID 29373334, PMID 29406176, PMID 29945801, PMID 30243062, PMID 30335625, PMID 30389535
2009 (3), 1UL1RR024975 (1), 2018 (1), 2019 (1), P01HL056693 (1), R01AG015466 (1), R01DK139484 (1), UL1RR024975-01 (1), UL1TR000445-06 (1)