Complex Regional Pain Syndromes: Clinical Trials

111 completed, 38 unknown, 30 recruiting, 21 terminated. 123 Not applicable, 24 Phase 3, 22 Phase 2, 8 Phase 4, 4 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	123	Completed 58, Recruiting 21, Unknown 21, Terminated 10, Not yet recruiting 5, Withdrawn 5, Enrolling by invitation 2, Active not recruiting 1
Phase 3	24	Completed 14, Unknown 4, Recruiting 2, Terminated 2, Withdrawn 2
Phase 2	22	Completed 9, Terminated 5, Unknown 4, Withdrawn 3, Suspended 1
Phase 4	8	Completed 5, Unknown 2, Enrolling by invitation 1
Phase 1	4	Completed 1, Recruiting 1, Terminated 1, Withdrawn 1
Early Phase 1	3	Active not recruiting 1, Completed 1, Unknown 1

Follow Complex Regional Pain Syndromes: new trials by email Literature Review of Complex Regional Pain Syndromes trials Research Report on Complex Regional Pain Syndromes

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes	Phase 2	Withdrawn	Stanford University		2099-01-01	2024-11-22
Ketamine HCl Prolonged Release Oral Tablets for CRPS 80mg/day Ketamine HCl Prolonged Release, 160mg/day Ketamine HCl Prolonged Release - Complex Regional Pain Syndromes	Phase 2	Suspended	University of Southern California	65	2027-01-01	2026-07-27
Validity and Reliability of the Turkish Version of the Revised Bath CRPS Body Perception Disturbance Scale Complex Regional Pain Syndrome (CRPS)		Not yet recruiting	Izmir Democracy University	42	2026-11-15	2026-10-06
Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1 Neridronate - Complex Regional Pain Syndrome Type I	Phase 3	Recruiting	Ambros Therapeutics, Inc.	135	2026-10-13	2026-10-16
Graded Motor Imagery Effects on Body Perception Disturbance in Complex Regional Pain Syndrome : a Randomised Controlled Trial Graded Motor Imagery + Therapeutic exercises, Sham-GMI (non-motor mental imagery) + Therapeutic exercises - Complex Regional Pain Syndromes	Not applicable	Not yet recruiting	Nantes University Hospital	80	2026-10-01	2026-09-14
Empowered Relief for Caregivers Empowered Relief for Caregivers (ER-CY) - Chronic Pain, Musculoskeletal Pain	Not applicable	Not yet recruiting	Stanford University	80	2026-10-01	2026-08-20
Effects of Non-invasive Brain Stimulation on Pain Avoidance Behavior in Chronic Pain Patients transcranial alternating current stimulation (tACS) - Complex Regional Pain Syndrome (CRPS)	Not applicable	Recruiting	The Cleveland Clinic	30	2026-10-01	2026-08-28
CRPS-RISE Outcomes Registry Complex Regional Pain Syndrome I (CRPS I)		Recruiting	Ambros Therapeutics, Inc.	270	2026-09-17	2026-09-29
How the Brain and Body Recover After a Wrist Fracture Wrist Fracture, Complex Regional Pain Syndrome		Recruiting	Cambridge University Hospitals NHS Foundation Trust	200	2026-08-12	2026-08-20
Transcutaneous Auricular Vagus Nerve Stimulation Added to Rehabilitation for Complex Regional Pain Syndrome Type I Active Transcutaneous Auricular Vagus Nerve Stimulation, Sham Transcutaneous Auricular Vagus Nerve Stimulation, Standard Rehabilitation Program - Complex Regional Pain Syndrome Type I	Not applicable	Not yet recruiting	Liv Hospital Vadistanbul	20	2026-07-15	2026-07-17
ESWT for CRPS-I After Distal Radius Fracture Active ESWT will be applied once weekly for a total of five sessions to the affected distal forearm, wrist, and painful soft-tissue areas.Associated Arm: Standard Rehabilitation + Active ESWT, Sham Extracorporeal Shock Wave Therapy (Sham ESWT), Standard Rehabilitation Program - Complex Regional Pain Syndrome Type I (CRPS-I), Distal Radius Fracture	Not applicable	Recruiting	Dilek ün oguzhanasilturk	60	2026-06-26	2026-09-08
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain Chronic Pain, PERIPHERAL NEUROPATHY		Recruiting	Yale University	80	2026-06-20	2026-08-21
Predicting Pain Exacerbations in Children With Complex Regional Pain Syndrome (CRPS) Apple Watch v8 - Complex Regional Pain Syndromes		Withdrawn	Stanford University		2026-06-01	2026-05-08
CRPS-Hand: Contrast + Compression vs Whirlpool Combined Contrast Therapy with Intermittent Compression, Whirlpool Therapy - Complex Regional Pain Syndrome I (CRPS I)	Not applicable	Recruiting	Ankara Etlik City Hospital	50	2026-05-01	2026-08-04
Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE) Neridronate, Placebo - Complex Regional Pain Syndrome Type I	Phase 3	Recruiting	Ambros Therapeutics, Inc.	270	2026-04-14	2026-10-29
Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome Early hyperbaric oxygen therapy (HBOT), Delayed hyperbaric oxygen therapy (HBOT) - Chronic Pain, Complex Regional Pain Syndrome	Not applicable	Recruiting	University Hospital Ostrava	60	2026-04-01	2026-08-25
Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome transcranial direct current stimulation, Placebo - Complex Regional Pain Syndrome (CRPS)	Not applicable	Recruiting	Polyclinique de l'Europe	32	2026-04-01	2026-06-18
Perineural Incobotulinumtoxin-A for Complex Regional Pain Syndrome - An Open-label Feasibility Study Perineural Incobotulinumtoxin-A 200 U - CRPS (Complex Regional Pain Syndromes), CRPS (Complex Regional Pain Syndrome) Type I	Not applicable	Recruiting	Bo Biering-Soerensen	20	2026-01-07	2026-03-16
NEURO-MODULATORY EFFECT OF ELECTRO-ACUPUNCTURE ON COMPLEX REGIONAL PAIN SYNDROME IN POST STROKE PATIENTS Electroacupuncture, Conventional physical therapy program - Stroke	Not applicable	Completed	Ahmed Alshimy	40	2026-01-05	2026-10-09
Peripersonal Space Representation in Upper Limb Segmental Exclusion Reachability Judgment Task in VR. - Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS)		Recruiting	Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est	60	2025-12-04	2026-03-16

Showing 20 of 227. Sign in to see all of them.

Narrower conditions

Chronic Pain (47)  ·  Reflex Sympathetic Dystrophy (42)  ·  Pain (39)  ·  Neuralgia (33)  ·  Causalgia (17)  ·  Fibromyalgia (15)  ·  Neuralgia, Postherpetic (14)  ·  Wrist Fractures (10)  ·  Agnosia (9)  ·  Osteoarthritis (9)  ·  Peripheral Nervous System Diseases (9)  ·  Stroke (9)  ·  Failed Back Surgery Syndrome (8)  ·  Arthritis, Rheumatoid (7)

Broader conditions

Autonomic Nervous System Diseases (227)  ·  Nervous System Diseases (227)  ·  Neuromuscular Diseases (227)  ·  Peripheral Nervous System Diseases (218)  ·  Pathological Conditions, Signs and Symptoms (114)  ·  Signs and Symptoms (113)  ·  Neurologic Manifestations (112)  ·  Pain (68)  ·  Musculoskeletal Diseases (26)  ·  Wounds and Injuries (24)  ·  Pathologic Processes (22)  ·  Rheumatic Diseases (22)  ·  Neuralgia (20)  ·  Central Nervous System Diseases (19)

Interventions

Ketamine (7)  ·  6-amino-1-hydroxyhexane-1,1-diphosphonate (6)  ·  Lidocaine (6)  ·  Transcranial Magnetic Stimulation (6)  ·  Mirror Movement Therapy (5)  ·  Control Groups (4)  ·  Transcranial Direct Current Stimulation (4)  ·  Ascorbic Acid (3)  ·  Bupivacaine (3)  ·  Ibuprofen (3)  ·  Physical Therapy Modalities (3)  ·  Rehabilitation (3)  ·  Saline Solution (3)  ·  Sodium Chloride (3)  ·  Botulinum Toxins, Type A (2)

Sponsors

Stanford University (10)  ·  Hospital for Special Surgery, New York (6)  ·  Ruhr University of Bochum (6)  ·  Seoul National University (5)  ·  Amgen (4)  ·  Grünenthal GmbH (4)  ·  The Cleveland Clinic (4)  ·  Ambros Therapeutics, Inc. (3)  ·  Centre Hospitalier Universitaire de Saint Etienne (3)  ·  Children's Hospital Medical Center, Cincinnati (3)  ·  McMaster University (3)  ·  National Institute of Nursing Research (NINR) (3)  ·  Albany Medical College (2)  ·  Ankara City Hospital Bilkent (2)  ·  Ankara Etlik City Hospital (2)

Countries

United States (94)  ·  France (19)  ·  Canada (17)  ·  Turkey (Türkiye) (14)  ·  Germany (10)  ·  United Kingdom (8)  ·  South Korea (7)  ·  Egypt (6)  ·  Netherlands (5)  ·  Denmark (4)  ·  Italy (4)  ·  Sweden (4)  ·  Taiwan (4)  ·  Belgium (3)  ·  Czechia (3)

Top investigators

Semih Gungor, MD (3)  ·  Alexandra Sideris, PhD (2)  ·  Christoph Maier, Prof. Dr. (2)  ·  Jee Youn Moon, MD, PhD (2)  ·  Jeongsoo Kim, MD (2)  ·  Jianren Mao, M.D., Ph.D. (2)  ·  Laura Simons, PhD (2)  ·  Steven Richeimer, MD (2)  ·  Troels S Jensen, MD, DMSc (2)  ·  Veronique Brulotte, MD (2)  ·  Adam Rufa, DPT, PhD (1)

Results publications

PMID 12020526, PMID 20965657, PMID 26165391, PMID 34854473, PMID 35579382, PMID 35687369, PMID 10568846, PMID 10636366, PMID 10863041, PMID 11733293, PMID 12098613, PMID 12595868, PMID 12749974, PMID 15453912, PMID 16040256, PMID 16688616, PMID 1671794, PMID 16977490, PMID 17610454, PMID 17629925, PMID 18346583, PMID 18723287, PMID 19465507, PMID 19628433, PMID 19707887, PMID 20693883, PMID 20851058, PMID 21267044, PMID 21600053, PMID 21683929, PMID 21816540, PMID 21992784, PMID 22022040, PMID 22131791, PMID 22386473, PMID 22515496, PMID 22588748, PMID 23158966, PMID 23171669, PMID 23185727, PMID 23331950, PMID 24462502, PMID 24668314, PMID 24760493, PMID 25250722, PMID 25283471, PMID 25317283, PMID 25495134, PMID 25747936, PMID 25919011

NIH funding

2009 (2), 2015 (2), 2016 (2), 2014 (1), 2017 (1), K23NS050485 (1), P01NS041386 (1), R01AT010817 (1), R21AT013595 (1), UH3NS115631 (1)