94 completed, 10 recruiting, 10 terminated, 10 unknown. 57 Phase 1, 30 Phase 2, 16 Phase 4, 15 Phase 3, 13 Not applicable.
Follow Dextromethorphan: new trials by email Literature Review of Dextromethorphan trials Research Report on Dextromethorphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis Afimkibart, Caffeine, Warfarin - Active Ulcerative Colitis | Phase 1 | Recruiting | Hoffmann-La Roche | 25 | 2026-06-29 | 2026-10-16 |
| A Study of Psychedelics in Healthy Older Adults With Low Well-being Psilocybin (drug), Dextromethorphan (DXM) - Anhedonia in Healthy Volunteers, Older Adults (50-90 Years) | Phase 1 | Recruiting | Jennifer Mitchell | 80 | 2026-06-01 | 2026-09-09 |
| Nintedanib With or Without Dextromethorphan in Patients With Idiopathic Pulmonary Fibrosis (IPF) Nintedanib,Dextromethorphan, Nintedanib,Placebo - Idiopathic Pulmonary Fibrosis (IPF) | Phase 2 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 60 | 2026-05-12 | 2026-05-13 |
| A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Dextromethorphan (CYP2D6 Substrate) in Healthy Participants Dextromethorphan, Capivasertib - Healthy Participants | Phase 1 | Completed | AstraZeneca | 42 | 2026-03-19 | 2026-07-27 |
| Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia EXV-802, Placebo, EXV-801 - Agitation Associated With Alzheimer's Disease Dementia | Phase 2 / Phase 3 | Recruiting | Exciva GmbH | 300 | 2026-02-02 | 2026-08-14 |
| A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma. Omeprazole, Dextromethorphan - Hodgkin Lymphoma, Non Hodgkin Lymphoma | Phase 1 | Recruiting | Murdoch Childrens Research Institute | 10 | 2025-07-22 | 2026-08-27 |
| A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder Dextromethorphan and Bupropion Sustained-Release Tablets, Placebo - Major Depressive Disorder (MDD) | Phase 3 | Recruiting | CSPC Ouyi Pharmaceutical Co., Ltd. | 388 | 2025-04-11 | 2025-05-06 |
| Investigation of Psychedelic Effects in Psychoactive Substances Placebo, Psilocybin, Ketamine - Psychedelic Effects in Healthy Volunteers | Phase 1 | Recruiting | Johns Hopkins University | 50 | 2025-02-05 | 2026-02-23 |
| A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates BMS-984923, Midazolam, Caffeine - Drug Drug Interaction (DDI) | Phase 1 | Active not recruiting | Allyx Therapeutics | 36 | 2024-11-04 | 2025-02-07 |
| KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism Caffeine Tablet, Bupropion Hydrochloride Capsels, Repaglinide Capsels - Drug Interaction | Not applicable | Completed | Helsinki University Central Hospital | 12 | 2024-08-22 | 2026-03-06 |
| Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects JMKX001899, Itraconazole, Midazolam - Solid Tumor, Adult | Phase 1 | Unknown | Jemincare | 72 | 2024-04-01 | 2024-04-04 |
| Psilocybin-facilitated Treatment for Chronic Pain Psilocybin, Dextromethorphan - Fibromyalgia, Primary | Early Phase 1 | Recruiting | University of Alabama at Birmingham | 30 | 2023-11-01 | 2026-03-11 |
| Dextromethorphan as an Augmentation Agent in Treatment-resistant Schizophrenia Dextromethorphan, Placebo - Treatment Resistant Schizophrenia | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 40 | 2023-08-31 | 2025-05-09 |
| A Study of IBI351 in Healthy Subjects Itraconazole, IBI351, Dextromethorphan - Healthy Subjects | Phase 1 | Completed | Innovent Biologics (Suzhou) Co. Ltd. | 24 | 2023-03-10 | 2023-10-24 |
| DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan Acoziborole, Midazolam, Dextromethorphan - Trypanosomiasis, African | Phase 1 | Completed | Drugs for Neglected Diseases | 20 | 2023-02-09 | 2023-07-17 |
| A Drug Interaction Study of LY3871801 in Healthy Participants LY3871801, Methotrexate, Warfarin - Healthy | Phase 1 | Completed | Eli Lilly and Company | 39 | 2022-11-02 | 2023-04-18 |
| Dextromethorphan for Treatment of Postoperative Pain Dextromethorphan Hydrobromide, Placebo - Post-operative Pain | Not applicable | Recruiting | Nathanael Heckmann | 160 | 2022-09-15 | 2026-03-27 |
| A Study of Imlunestrant (LY3484356) in Female Healthy Participants Imlunestrant, Repaglinide, Omeprazole - Healthy | Phase 1 | Completed | Eli Lilly and Company | 113 | 2022-07-07 | 2025-12-12 |
| Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir Midazolam, Repaglinide, Dextromethorphan - Malaria | Phase 1 | Completed | Novartis Pharmaceuticals | 48 | 2022-03-09 | 2022-11-04 |
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Pain (5) · Agnosia (4) · Cough (4) · Depressive Disorder, Major (4) · Rett Syndrome (4) · Amyotrophic Lateral Sclerosis (3) · Diabetes Mellitus (3) · Diabetes Mellitus, Type 2 (3) · Hyperalgesia (3) · Inflammation (3) · Neuralgia (3) · Pain, Postoperative (3) · Alzheimer Disease (2) · Bipolar Disorder (2) · Chronic Pain (2)
National Cheng-Kung University Hospital (7) · Pfizer (5) · Eli Lilly and Company (4) · GlaxoSmithKline (4) · Janssen Research & Development, LLC (4) · Jules Desmeules (4) · Avanir Pharmaceuticals (3) · Boehringer Ingelheim (3) · All India Institute of Medical Sciences, Bhubaneswar (2) · Brigham and Women's Hospital (2) · Bristol-Myers Squibb (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (2) · Johns Hopkins University (2) · National Institute of Dental and Craniofacial Research (NIDCR) (2)
United States (74) · Taiwan (9) · Canada (7) · Germany (7) · Belgium (6) · United Kingdom (6) · Switzerland (4) · Poland (3) · China (2) · Czechia (2) · France (2) · India (2) · Netherlands (2) · South Korea (2) · Spain (2)
Ru-Band Lu, MD (4) · Christine N. Sang, MD, MPH (2) · Jules A Desmeules, Pr (2) · Tzu-Yun Wang (2) · Adrian Hepner, M.D. (1) · Alin O Stirban, MD (1) · Alin Stirban, MD (1) · Alyssa Galley (1)
PMID 17397698, PMID 18056558, PMID 20839238, PMID 21844413, PMID 22288567, PMID 22337680, PMID 22730040, PMID 24018772, PMID 24722393, PMID 24948402, PMID 25636304, PMID 25673148, PMID 26362564, PMID 27411694, PMID 27495955, PMID 27746690, PMID 27867308, PMID 28194724, PMID 28916283, PMID 29439084, PMID 29532791, PMID 29570971, PMID 29660207, PMID 30584490, PMID 31099895, PMID 31333511, PMID 31385617, PMID 31447547, PMID 32115672, PMID 32407591, PMID 32719417, PMID 32755625, PMID 33070149, PMID 33904154, PMID 34242798, PMID 35135601, PMID 36332661, PMID 36991450, PMID 37768317, PMID 37864393, PMID 38424308, PMID 38688675, PMID 38878209, PMID 39551007, PMID 40259519, PMID 41499296, PMID 41780197, PMID 42649324
2016 (2), 2018 (2), R01NS041503 (2), 2014 (1), 2017 (1), 2019 (1), 2023 (1), 2025 (1), P01GM032165 (1), P01HD024448 (1), P30CA014520 (1), P30CA015083 (1), P30CA072720 (1), R01GM124264 (1), SB1AG087748 (1)