120 completed, 53 unknown, 51 recruiting, 26 terminated. 163 Not applicable, 24 Phase 4, 8 Phase 3, 3 Phase 2, 2 Phase 1.
Follow Heart Block: new trials by email Literature Review of Heart Block trials Research Report on Heart Block
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Leadless Versus Conventional Pacemakers: Effects on Heart Function and Heart Failure Leadless pacemaker implantation, Conventional transvenous pacemaker implantation - Bradycardia, Atrioventricular Block | Not applicable | Not yet recruiting | Karl Landsteiner University of Health Sciences | 760 | 2027-11-01 | 2026-11-10 |
| Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG digital single-channel ECG recording - Atrial Fibrillation, Atrioventricular Block, Second and Third Degree | Not yet recruiting | I.M. Sechenov First Moscow State Medical University | 300 | 2026-12-31 | 2026-02-10 | |
| Belgo-Luxembourg Leadless PM Registry CT scan heart, 24 hour ambulatory ECG monitoring - Bradyarrhythmias, AV Block Complete | Not applicable | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 190 | 2026-11-01 | 2026-10-19 |
| LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI Left bundle branch area pacing with pacemaker, Implantation loop recorder - TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block | Not applicable | Not yet recruiting | University Hospital, Clermont-Ferrand | 700 | 2026-10-15 | 2026-11-02 |
| Transjugular Approach for Implantation of Active Fixation Leadless Pacemakers Aveir VR Leadless Pacemaker - Bradycardia, Heart Block | Not applicable | Recruiting | Min Shen | 15 | 2026-10-10 | 2026-11-10 |
| Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP) - Bradycardia, Atrioventricular Block | Not applicable | Not yet recruiting | Yonsei University | 300 | 2026-10-01 | 2026-09-04 |
| Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in Japan Application of ambulatory cardiac monitor - Atrial Fibrillation (AF), Atrial Flutter | Not applicable | Not yet recruiting | iRhythm Technologies, Inc. | 130 | 2026-09-30 | 2026-10-19 |
| OPTImizing Lead Placement in Patients Requiring Pacemaker After Cardiac Surgery Left bundle branch area pacing, Conventional pacing strategy - Atrioventricular Block, Cardiac Surgery | Not applicable | Not yet recruiting | Sahlgrenska University Hospital | 110 | 2026-09-10 | 2026-08-31 |
| SPIKE FLOW Endocardial Lead Safety and Performance Study Lead insertion, lead removal - Acute Myocardial Infarction (AMI), Asystole | Not applicable | Recruiting | FIAB SpA | 131 | 2026-08-07 | 2026-11-12 |
| REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints Physiologic cardiac resynchronization using conduction system pacing and selective LV lead optimization. - Heart Failure - NYHA II - IV, Left Bundle Branch Area Pacing | Not yet recruiting | University of Pecs | 50 | 2026-06-29 | 2026-07-10 | |
| ALPs Single ChambEr New Device Leadless ventricular pacemaker implantation - Bradycardia, Brady-tachy Syndrome | Not applicable | Not yet recruiting | Cairdac SA | 10 | 2026-06-01 | 2026-03-10 |
| ALPs Single ChambEr New Device Study Leadless ventricular pacemaker implantation - Brady-tachy Syndrome, Brady Arrythmia | Not applicable | Not yet recruiting | Cairdac SA | 15 | 2026-06-01 | 2026-03-18 |
| Machine Learning for Diagnosis of Occlusive MI in LBBB Patients Digital 12-Lead ECG Analysis and Invasive Coronary Angiography - Acute Myocardial Infarction (AMI), Left Bundle Branch Block | Recruiting | Konya City Hospital | 50 | 2026-06-01 | 2026-06-02 | |
| BIO|STREAM.CSP CLS Left bundle branch area pacing with Closed Loop Stimulation - Sinus Node Disease, Atrioventricular Block | Recruiting | Biotronik SE & Co. KG | 150 | 2026-05-29 | 2026-07-17 | |
| Multimodality Location Prediction Accuracy of Leadless Pacemaker Positioning Cardiac Imaging by TTE or CTA - Sinus Pause, Sinus Sick Syndrome | Not applicable | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 20 | 2026-05-13 | 2026-11-02 |
| Evaluation of Accelerated Bachmann Bundle Area Pacing in Heart Failure With Reduced ejectIon Fraction Who Have electrocarDioGraphic Evidence of Interatrial Block and Indicated for Implantable Cardioverter Defibrillator BBAP on, BBAP off, RAAP - Heart Failure and Reduced Ejection Fraction | Not applicable | Not yet recruiting | Seoul National University Hospital | 120 | 2026-05-01 | 2026-04-23 |
| BIOTRONIK Investigation of the LivIQ Leadless Pacemaker System LivIQ Leadless Pacemaker System - Leadless Pacemaker, Bradycardia | Not applicable | Recruiting | Biotronik, Inc. | 325 | 2026-03-16 | 2026-10-16 |
| Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF Right Ventricular Pacing, Left Bundle Branch Pacing - Atrial Fibrillation (AF), Pacemaker Therapy | Not applicable | Recruiting | University Hospital of Patras | 244 | 2026-02-05 | 2026-03-13 |
| LLL vs. SDL for LBBP: A Non-inferiority RCT SDL implantation, LLL implantation - Bradycardia, Conduction Block, Atrioventricular | Not applicable | Not yet recruiting | Ningbo No.2 Hospital | 288 | 2026-01-24 | 2026-02-03 |
| Efficacy and Safety of Micra AV2 Transcatheter Pacing System Implant procedure of a Micra AV2 leadless pacemaker (Medtronic) - AV Block Complete, AV Block-2Nd Degree-Type 1 | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 150 | 2026-01-12 | 2026-01-21 |
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Atrioventricular Block (113) · Bundle-Branch Block (93) · Sick Sinus Syndrome (93) · Heart Failure (75) · Bradycardia (56) · Atrial Fibrillation (39) · Arrhythmias, Cardiac (32) · Aortic Valve Stenosis (13) · Syncope (10) · Tachycardia, Ventricular (10) · Cardiomyopathies (8) · Heart Diseases (8) · Heart Failure, Systolic (8) · Syncope, Vasovagal (8)
Pathologic Processes (289) · Pathological Conditions, Signs and Symptoms (289) · Cardiac Conduction System Disease (288) · Cardiovascular Diseases (285) · Heart Diseases (281) · Arrhythmias, Cardiac (257) · Arrhythmia, Sinus (92) · Nervous System Diseases (24) · Neurologic Manifestations (20) · Signs and Symptoms (20) · Consciousness Disorders (17) · Neurobehavioral Manifestations (17) · Unconsciousness (17) · Aortic Valve Disease (13)
Cardiac Resynchronization Therapy (14) · Transcatheter Aortic Valve Replacement (5) · Defibrillators (4) · Exercise Test (3) · Device Lead Extraction (2) · Dexamethasone (2) · Methylprednisolone (2) · Observation (2) · Pacemaker, Artificial (2) · Adenosine (1) · Adrenal Cortex Hormones (1) · Adrenergic beta-Antagonists (1) · Atenolol (1) · Bacitracin (1) · Blood Specimen Collection (1)
Abbott Medical Devices (17) · Medtronic Cardiac Rhythm and Heart Failure (16) · Boston Scientific Corporation (8) · Medtronic BRC (5) · BackBeat Medical Inc (4) · Biotronik SE & Co. KG (4) · Biotronik, Inc. (4) · LivaNova (4) · Maastricht University Medical Center (4) · Aalborg University Hospital (3) · Copenhagen University Hospital, Rigshospitalet (3) · Duke University (3) · The First Affiliated Hospital with Nanjing Medical University (3) · Tomsk National Research Medical Center of the Russian Academy of Sciences (3) · Universitaire Ziekenhuizen KU Leuven (3)
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