46 completed, 19 unknown, 10 recruiting, 9 terminated. 47 Not applicable, 11 Phase 4, 5 Phase 3, 2 Phase 2.
Follow this condition Literature Review of Sick Sinus Syndrome trials Research Report on Sick Sinus Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG digital single-channel ECG recording - Atrial Fibrillation, Atrioventricular Block, Second and Third Degree | Not yet recruiting | I.M. Sechenov First Moscow State Medical University | 300 | 2026-12-31 | 2026-02-10 | |
| Belgo-Luxembourg Leadless PM Registry CT scan heart, 24 hour ambulatory ECG monitoring - Bradyarrhythmias, AV Block Complete | Not applicable | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 190 | 2026-11-01 | 2026-10-19 |
| Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP) - Bradycardia, Atrioventricular Block | Not applicable | Not yet recruiting | Yonsei University | 300 | 2026-10-01 | 2026-09-04 |
| Transjugular Approach for Implantation of Active Fixation Leadless Pacemakers Aveir VR Leadless Pacemaker - Bradycardia, Heart Block | Not applicable | Not yet recruiting | Min Shen | 15 | 2026-09-10 | 2026-09-03 |
| BIO|STREAM.CSP CLS Left bundle branch area pacing with Closed Loop Stimulation - Sinus Node Disease, Atrioventricular Block | Recruiting | Biotronik SE & Co. KG | 150 | 2026-05-29 | 2026-07-17 | |
| Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up Pacemaker lead - Bradycardia, Atrioventricular Block | Recruiting | Boston Scientific Corporation | 140 | 2025-12-19 | 2026-10-07 | |
| LEAP 2 Chronic EFS AVEIR CSP Leadless Pacemaker System - Cardiac Pacemaker, Cardiac Rhythm Disorder | Not applicable | Recruiting | Abbott Medical Devices | 30 | 2025-12-13 | 2026-10-16 |
| Prospective Cohort Study of Bachmann Bundle Versus Right Atrial Appendage Pacing: Impact on Atrial Cardiomyopathy Evaluated by Echocardiographic Parameters and Clinical Outcome Right Atrial Appendage Pacing, Bachmann Bundle Pacing - Sick Sinus Syndrome | Recruiting | Samsung Medical Center | 200 | 2025-12-09 | 2026-07-28 | |
| PACE-AF: Prospective Analysis of Cardiac Electrostimulation and Atrial Fibrillation Atrial Fibrillation, Sick Sinus Syndrome | Not yet recruiting | Ilya Lukin | 500 | 2025-12-01 | 2025-12-12 | |
| Left Bundle Branch Versus Minimized Ventricular Pacing in Patients With Sick Sinus Syndrome and Prolonged AV Interval LBBAP, MVP - Sick Sinus Syndrome, Atrioventricular Nodal Dysfunction | Not applicable | Recruiting | Asan Medical Center | 440 | 2025-05-02 | 2026-01-02 |
| AVEIR™ Leadless Pacemaker Registry in Europe and MIddle East Region (PREMIER LEADLESS) Cardiac Pacing in Adherence With ESC Cardiac Pacing Guidelines | Not yet recruiting | King Fahad Armed Forces Hospital | 1698 | 2025-01-06 | 2025-01-17 | |
| BIOTRONIK Conduction System Pacing With the Solia Lead - Solia CSP S Solia CSP S lead - Sinus Node Dysfunction, Bradycardia | Not applicable | Completed | Biotronik, Inc. | 192 | 2024-12-18 | 2026-07-14 |
| Evaluating the Safety and Effectiveness of 5G Cloud Follow-up for Cardiovascular Implantable Electronic Devices Routine Management, 5G Cloud Follow-up - Sick Sinus Syndrome, Atrioventricular Block, Second and Third Degree | Not applicable | Recruiting | The Third People's Hospital of Chengdu | 688 | 2024-11-13 | 2024-11-21 |
| Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias Focal Cryoablation, Radiofrequency Catheter Ablation - Bradycardia, Syncope, Vasovagal | Not applicable | Recruiting | Tomsk National Research Medical Center of the Russian Academy of Sciences | 60 | 2024-09-01 | 2026-06-26 |
| Cardioneuroablation for Bradyarrhythmia Ganglionated plexi ablation, Electrophysiological study - Bradycardia, Syncope | Not applicable | Recruiting | Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health | 106 | 2024-03-04 | 2024-03-05 |
| Cardiac Denervation Ablation Strategy for Severe Sinus Bradycardia Sinus Bradycardia | Unknown | China National Center for Cardiovascular Diseases | 88 | 2023-09-13 | 2024-02-26 | |
| LBBAP Data Collection Registry Implantation of the Tendril 2088 lead in the LBBA - Bradycardia, Sinus Node Dysfunction | Completed | Abbott Medical Devices | 221 | 2023-04-25 | 2024-10-08 | |
| Allometric-Pace Study Pacemaker lower rate setting - Sinus Node Dysfunction | Completed | Medtronic Cardiac Rhythm and Heart Failure | 73 | 2023-03-20 | 2025-02-07 | |
| Atrial Synchrony Evaluation of Bachmann Bundle Pacing in Sick Sinus Syndrome Bachmann Bundle Pacing, Right Atrial Appendage Pacing - Sick Sinus Syndrome | Not applicable | Completed | Shiyan City Renmin Hospital | 72 | 2023-01-01 | 2025-07-08 |
| Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment Right heart catheterization - Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent | Not applicable | Unknown | Shanghai 10th People's Hospital | 100 | 2022-11-01 | 2022-12-29 |
Showing 20 of 92. Sign in to see all of them.
Bradycardia (32) · Atrioventricular Block (23) · Atrial Fibrillation (22) · Heart Failure (13) · Heart Block (11) · Arrhythmias, Cardiac (10) · Syncope (6) · Ventricular Fibrillation (5) · Syncope, Vasovagal (4) · Tachycardia, Ventricular (4) · Ventricular Dysfunction (4) · Cardiomyopathies (3) · Heart Diseases (3) · Bundle-Branch Block (2)
Pathologic Processes (92) · Pathological Conditions, Signs and Symptoms (92) · Arrhythmia, Sinus (91) · Cardiac Conduction System Disease (91) · Cardiovascular Diseases (90) · Heart Diseases (89) · Arrhythmias, Cardiac (82) · Heart Block (81) · Nervous System Diseases (11) · Consciousness Disorders (9) · Neurobehavioral Manifestations (9) · Neurologic Manifestations (9) · Signs and Symptoms (9) · Unconsciousness (9) · Autonomic Nervous System Diseases (5)
Defibrillators (2) · Atenolol (1) · Bacitracin (1) · Blood Specimen Collection (1) · Catheter Ablation (1) · Cephalexin (1) · Clindamycin (1) · Defibrillators, Implantable (1) · Device Lead Extraction (1) · Electrophysiologic Techniques, Cardiac (1) · Ivabradine (1) · Levofloxacin (1) · Losartan (1) · Nebivolol (1) · Observation (1)
Abbott Medical Devices (11) · Medtronic Cardiac Rhythm and Heart Failure (7) · Boston Scientific Corporation (5) · Biotronik SE & Co. KG (4) · Medtronic BRC (4) · LivaNova (3) · Biotronik, Inc. (2) · China National Center for Cardiovascular Diseases (2) · Guidant Corporation (2) · Tartu University Hospital (2) · Tongji Hospital (2) · Aarhus University Hospital (1) · Aarhus University Hospital Skejby (1) · Arun Rao (1) · Asan Medical Center (1)
United States (22) · Italy (14) · China (13) · France (13) · Germany (12) · Belgium (9) · Spain (9) · United Kingdom (9) · Netherlands (7) · Austria (6) · Canada (6) · Denmark (6) · Russia (6) · Singapore (6) · Czechia (5)
Kwangdeok Lee (2) · Yan Wang, PhD (2) · Alessandro Capucci (1) · Andi Albertsen, MD (1) · Arun Rao, MD (1) · C Nimeth, MD (1) · Carlos Minguito Carazo, MD (1) · Carmine Muto, MD (1) · Charles Love, MD (1) · Chih-Chieh Yu, MD.PhD (1) · Chirag Barbhaiya, MD (1) · Chris van Groeningen, MD (1) · Christopher Ellis, M.D. (1) · Chu-Pak Lau, Prof. (1)
PMID 30354289, PMID 33999698, PMID 10805823, PMID 11310300, PMID 11513442, PMID 12063369, PMID 12494610, PMID 12842643, PMID 14585254, PMID 15189520, PMID 16014884, PMID 17367361, PMID 17804844, PMID 18950302, PMID 21300730, PMID 21712276, PMID 21819434, PMID 21857020, PMID 22106360, PMID 22236222, PMID 22247754, PMID 22511657, PMID 23419655, PMID 23449923, PMID 23723446, PMID 23868858, PMID 25465496, PMID 25512875, PMID 25693516, PMID 27402231, PMID 27895044, PMID 28280231, PMID 29535066, PMID 29545242, PMID 29562304, PMID 29581554, PMID 29759604, PMID 29759719, PMID 29951525, PMID 30586772, PMID 30704289, PMID 31326478, PMID 31330187, PMID 31760820, PMID 32395337, PMID 33940549, PMID 34012407, PMID 34255038, PMID 34599455, PMID 34896621
2014 (1), U01HL049804 (1)