51 completed, 22 unknown, 15 recruiting, 11 terminated. 40 Phase 4, 25 Not applicable, 12 Phase 3, 11 Phase 2, 6 Phase 1.
Follow Adrenergic beta-Antagonists: new trials by email Literature Review of Adrenergic beta-Antagonists trials Research Report on Adrenergic beta-Antagonists
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Adherence to Guideline-Directed Medical Therapy in Patients With Advanced Heart Failure GDMT, Quality of life questionnaire - Heart Failure | Recruiting | Università Vita-Salute San Raffaele | 300 | 2026-05-08 | 2026-07-06 | |
| Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes Catheter ablation, Medical therapy: Anti-arrhythmic drugs (AAD) and/or beta-adrenergic blocking agents (BB) - Premature Ventricular Complexes, Premature Ventricular Contraction (PVC) | Not applicable | Recruiting | Western Sydney Local Health District | 50 | 2026-03-31 | 2026-09-24 |
| UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF Beta blocker - Heart Failure, Polygenic Score | Not applicable | Recruiting | David Lanfear | 10 | 2026-03-30 | 2026-07-07 |
| The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction mavacamten, Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol, diltiazem - Hypertrophic Cardiomyopathy (HCM) | Phase 4 | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 132 | 2026-03-01 | 2026-09-15 |
| Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App) beta blockers, StudyU Application - HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 5 | 2026-02-10 | 2026-02-19 |
| Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) Placebo (matching), Beta-blockers - Heart Failure, HFpEF | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 240 | 2026-02-02 | 2026-10-16 |
| Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication Catheter Ablation for Atrial Fibrillation, Rate Control Medications (beta-blockers, calcium channel blockers, digoxin) - Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction | Not applicable | Recruiting | Nova Scotia Health Authority | 84 | 2026-01-01 | 2026-10-20 |
| Efficacy and Safety of Shexiang Baoxin Pill(MUSKARDIA) in the Treatment of Acute Myocardial Infarction Aspirin, Shexiang Baoxin Pill - Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI) | Phase 4 | Not yet recruiting | Shanghai Hutchison Pharmaceuticals Limited | 9588 | 2025-09-01 | 2025-09-04 |
| Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy Prostaglandin Analogue -Containing IOP-Lowering Therapy, Beta Blocker, Brillouin Microscopy - Glaucoma | Recruiting | University of Maryland, Baltimore | 60 | 2025-09-01 | 2026-08-10 | |
| Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk Beta Blocker, ACE inhibitor, Calcium channel blocker - Hypertension, Fall Risk | Not applicable | Recruiting | Abant Izzet Baysal University | 186 | 2025-08-01 | 2026-02-12 |
| Sacubitril-valsartan in Patients With Heart Failure. Sacubitril-valsartan, standard treatment of heart failure - Heart Failure | Not applicable | Completed | Damanhour University | 60 | 2025-08-01 | 2026-04-21 |
| Inhibiting Beta-adrenergic and COX-2 Signaling During the Perioperative Period to Reduce Ovarian Cancer Progression Propranolol (Beta-Blocker) and Etodolac (COX-2 Inhibitor), Placebo (Matching for Propranolol & Etodolac) - Ovarian Cancer, Ovarian Cancer Metastatic Recurrent | Phase 2 | Recruiting | Tel-Aviv Sourasky Medical Center | 60 | 2025-03-12 | 2025-07-11 |
| N-of-1 in ATS and MEPPC Flecainide, Flecainide + beta-blocker - Andersen Tawil Syndrome, Multifocal Ectopic Purkinje-related Premature Contractions | Phase 2 | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 10 | 2025-03-01 | 2025-01-29 |
| Early Identification and Treatment of Rare Cardiomyopathy Cohorts diuretics, ACEIs/ARBs, beta blockers, positive inotropic drugs, MRAs, SGLT2i, retinoids, Close follow-up, early rehabilitation guidance - Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM) | Not applicable | Not yet recruiting | RenJi Hospital | 300 | 2025-02-01 | 2025-01-27 |
| Beta-Blockers in Takotsubo Syndrome Study Beta blocker - Takotsubo Cardiomyopathy, Beta-blockers | Phase 4 | Not yet recruiting | Spanish Society of Cardiology | 200 | 2024-08-01 | 2024-08-26 |
| Impact of Beta Blockers on TAVI (BETA-TAVI) Beta blocker - Aortic Valve Stenosis | Phase 4 | Recruiting | National and Kapodistrian University of Athens | 348 | 2024-06-01 | 2026-10-20 |
| Detoxification From the Lipid Tract electroencephalogram biofeedback, electrical brain stimulation, ultra-low frequency transcranial magnetic stimulation - COVID-19 Vaccine Adverse Reaction | Phase 4 | Completed | Pachankis, Yang I., M.D. | 1 | 2024-02-26 | 2024-04-10 |
| A Preliminary Study for INFORMED Beta blocker - Heart Failure, Heart Failure, Diastolic | Phase 4 | Recruiting | Weill Medical College of Cornell University | 18 | 2024-02-07 | 2026-08-21 |
| N-of-1 for Beta-Blockers in Cardiac Amyloidosis Beta blocker - Cardiac Amyloidosis, Heart Diseases | Phase 4 | Completed | Weill Medical College of Cornell University | 14 | 2024-01-31 | 2026-07-29 |
| Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker/angiotensin receptor-neprilysin inhibitor, The development of the prediction model - Mitral Regurgitation, Heart Failure | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 270 | 2024-01-01 | 2024-02-26 |
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Heart Failure (26) · Heart Diseases (13) · Atrial Fibrillation (11) · Hypertension (10) · Cardiovascular Diseases (9) · Myocardial Infarction (7) · Acute Coronary Syndrome (4) · Coronary Artery Disease (4) · Diabetes Mellitus (4) · Fibrosis (4) · Breast Neoplasms (3) · Cardiomyopathy, Dilated (3) · Heart Failure, Diastolic (3) · Hemangioma (3) · Hypotension (3)
Weill Medical College of Cornell University (6) · University of Sao Paulo (3) · Assiut University (2) · Boehringer Ingelheim (2) · Cedars-Sinai Medical Center (2) · Chongqing Medical University (2) · Govind Ballabh Pant Hospital (2) · Johns Hopkins University (2) · NYU Langone Health (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · National Institute of Cardiology, Warsaw, Poland (2) · Policlinico Casilino ASL RMB (2) · RenJi Hospital (2) · Spanish Society of Cardiology (2) · Tel-Aviv Sourasky Medical Center (2)
United States (29) · China (11) · Italy (7) · United Kingdom (6) · Brazil (5) · Canada (5) · Spain (5) · Australia (3) · Egypt (3) · Israel (3) · Sweden (3) · Denmark (2) · Germany (2) · India (2) · Netherlands (2)
Parag Goyal, MD, MSc (4) · Parag Goyal, MD (2) · Shiv K Sarin, MD, DM (2) · Alan Maisel, MD (1) · Alberto Zanchetti (1) · Alp Ozel, PT, PhD (1) · Andrew Ambrosy, MD, MPH (1) · Anna Blecher, Dr. (1) · Anna Maria Scandroglio, MD (1) · Bernard Chaitman, MD (1) · Bertil Lindahl, Prof (1) · Burton Sobel (1) · Carlos Robles-Medranda, M.D. (1)
PMID 21145834, PMID 42478107, PMID 17105759, PMID 17543250, PMID 19152871, PMID 19329766, PMID 19407805, PMID 20551457, PMID 21051458, PMID 21444887, PMID 21473976, PMID 21617110, PMID 21742107, PMID 21768545, PMID 21835316, PMID 21884956, PMID 21911782, PMID 21953407, PMID 22025606, PMID 22032709, PMID 22493073, PMID 22496082, PMID 23008442, PMID 23071495, PMID 23141853, PMID 23327629, PMID 23410541, PMID 23434314, PMID 23500245, PMID 23500281, PMID 23580745, PMID 23735723, PMID 23757426, PMID 23857320, PMID 23910429, PMID 24159564, PMID 24178969, PMID 24297771, PMID 24727262, PMID 24906863, PMID 24931393, PMID 24979303, PMID 25193873, PMID 25281275, PMID 25480782, PMID 26267622, PMID 26271057, PMID 26399404, PMID 26764413, PMID 26853953
K76AG064428 (2), 2009 (1), K76AG088428 (1), R01AG091005 (1), R01HL082638 (1), R01HL126892 (1), R03HL138068 (1), R21CA291683 (1), R21EY035483 (1), R24AG064025 (1), U01HL061744 (1), U01HL061746 (1), U01HL061748 (1), U01HL062509 (1), U01HL063804 (1)