474 completed, 201 unknown, 195 recruiting, 85 not yet recruiting. 73 Phase 3, 70 Not applicable, 64 Phase 2, 8 Phase 4, 5 Early Phase 1.
Follow Observation: new trials by email Literature Review of Observation trials Research Report on Observation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information Biospecimen Collection, Chest Radiography, Computed Tomography - Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8 | Phase 2 | Recruiting | Children's Oncology Group | 51 | 2027-05-15 | 2026-09-24 |
| Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial Atezolizumab, Atezolizumab and Recombinant Human Hyaluronidase, Biospecimen Collection - Lung Non-Small Cell Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2027-03-02 | 2026-11-05 |
| Polatuzumab Vedotin, Mosunetuzumab, and Acalabrutinib for the Treatment of Mantle Cell Lymphoma, PAcMan Trial Polatuzumab Vedotin, Acalabrutinib, Mosunetuzumab - Mantle Cell Lymphoma | Phase 2 | Not yet recruiting | University of Washington | 27 | 2027-03-01 | 2026-11-02 |
| Timing, Trajectories and Prediction in Severe Dental Crowding: The Create SPACE (cSPACE) Early first premolar extraction with observation, Early first premolar extraction with planned fixed orthodontic treatment - Crowding of Teeth, Malocclusion; Displaced Teeth | Not applicable | Not yet recruiting | Vastra Gotaland Region | 300 | 2027-03-01 | 2026-11-02 |
| Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain Biospecimen Collection, Low-Dose Aspirin, Patient Observation - Endometrial Carcinoma | Phase 4 | Not yet recruiting | Mayo Clinic | 20 | 2027-02-12 | 2026-08-05 |
| Randomized Phase 2 Study Of Epcoritamab Vs Watch And Wait InPatients With Previously Untreated Low Tumor Burden FollicularLymphoma Epcoritamab, Observation - Randomized, Phase 2 | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 40 | 2027-02-12 | 2026-11-02 |
| Testing the Investigational Medication Pembrolizumab After Kidney Removal for Patients With Non-Clear Cell Renal Cell Carcinoma Biospecimen Collection, Bone Scan, Computed Tomography - Non-Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 | Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 400 | 2027-02-10 | 2026-07-08 |
| Risk-adapted Therapy in HPV-positive Oropharyngeal Cancer Using Circulating Tumor (ct) HPV DNA Profiling (ReACT 2.0) Pembroluzimab, Observation - HPV-positive Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma | Phase 2 | Withdrawn | Dana-Farber Cancer Institute | 2026-12-01 | 2026-10-08 | |
| Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy Observation - Aneurysm Cerebral | Not yet recruiting | Mayo Clinic | 100 | 2026-12-01 | 2026-01-07 | |
| Evaluation of Clinical Decision Support in Opioid Tapering Observational study without a prospective intervention - Medication Abuse, Harm Reduction | Not yet recruiting | University of Colorado, Denver | 200000 | 2026-11-01 | 2026-09-30 | |
| Immunotherapy in Neuroendocrine Carcinoma of the Cervix No study intervention; observational study. - Cervical Neuroendocrine Carcinoma | Not yet recruiting | Peking Union Medical College Hospital | 150 | 2026-11-01 | 2026-11-02 | |
| Mapping Recovery, Quality of Life, and Physical Function After Partial and Radical Nephrectomy None, observational study - Nephrectomy / Methods, Nephrectomy | Recruiting | Herlev and Gentofte Hospital | 150 | 2026-10-22 | 2026-11-03 | |
| China Treatment Trial for Tumor in Sellar Region With Unruptured Intracranial Aneurysm Tumor resection followed by aneurysm treatment, Aneurysm treatment followed by tumor resection, Observation - Unruptured Intracranial Aneurysms, Pituitary Neuroendocrine Tumor | Active not recruiting | Cheng sen | 608 | 2026-10-20 | 2026-10-21 | |
| Metabolites in Blood and Breath in Metabolic Conditions Observational Study - Inborn Errors of Metabolism, Epilepsy (Treatment Refractory) | Not yet recruiting | University Children's Hospital, Zurich | 100 | 2026-10-01 | 2026-08-12 | |
| Surgery After Verifying Existing Disease in Locally Advanced Operable Lung Cancer: A Pilot Study Observation without surgery, Standard-of-care surgery - Non-Small Cell Lung Cancer, Immunotherapy | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 14 | 2026-10-01 | 2026-08-14 |
| New Hearing Aid Users and Their Social Participation Observation - Hearing Loss, Hearing Aids | Not yet recruiting | University of Nottingham | 32 | 2026-10-01 | 2026-11-02 | |
| Prospective Registry of Exposure to Gepotidacin (PREG) None (Observational study) - Sexually Transmitted Diseases | Not yet recruiting | GlaxoSmithKline | 614 | 2026-09-30 | 2026-09-30 | |
| A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma No intervention (observational study) - Uterine Fibroid, Uterine Sarcoma | Not yet recruiting | Tongji Hospital | 500 | 2026-09-30 | 2026-10-08 | |
| Clinical Characteristics, Treatment, Diagnostic Findings, and Outcomes of Tuberculous Meningitis in Indonesia, 2022-2025 No intervention (observational study) - Tuberculous Meningitis | Recruiting | Ina-Respond | 300 | 2026-09-24 | 2026-11-10 | |
| Evaluation of Anterior Neck Ultrasound in Predicting Difficult Airway in Obese Patients None (Observational study) - Ultrasonography, Airway Management | Not yet recruiting | Gaziantep City Hospital | 52 | 2026-09-20 | 2026-09-10 |
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Franca Fagioli, MD (4) · Angela Jefferson, PhD (2) · Carsten Skarke, MD (2) · Garret A FitzGerald, MD (2) · George C Fox (2) · Harlan M Krumholz, MD, SM (2) · Henrik Gregersen, MD (2) · Hom-Lay Wang, DDS MSD PhD (2) · Jing Li, MD, PhD (2)
PMID 40881041, PMID 41911908, PMID 42335416, PMID 10329105, PMID 11114637, PMID 11535886, PMID 11570715, PMID 11576374, PMID 11596161, PMID 11680441, PMID 11762335, PMID 11996444, PMID 12091180, PMID 12583868, PMID 13105270, PMID 13126521, PMID 14609712, PMID 1494764, PMID 15293766, PMID 15561396, PMID 15867769, PMID 16096555, PMID 16167048, PMID 16282778, PMID 16390886, PMID 16391218, PMID 16403930, PMID 16461781, PMID 16680602, PMID 16757203, PMID 16994214, PMID 16994980, PMID 17074942, PMID 17184516, PMID 17227526, PMID 17262200, PMID 17470624, PMID 17554118, PMID 17629661, PMID 18178467, PMID 18506026, PMID 18728566, PMID 19029209, PMID 19034057, PMID 19061172, PMID 19436079, PMID 19494162, PMID 19671919, PMID 19777259, PMID 19801201
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