95 completed, 45 unknown, 25 recruiting, 18 terminated. 97 Not applicable, 29 Phase 4, 23 Phase 2, 14 Phase 3, 11 Phase 1.
Follow Heart Failure, Systolic: new trials by email Literature Review of Heart Failure, Systolic trials Research Report on Heart Failure, Systolic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart Failure Pharmacist/Cardiologist Virtual Team Digital Consultation - Heart Failure, Heart Failure, Systolic | Not applicable | Not yet recruiting | VA Office of Research and Development | 585 | 2026-11-01 | 2026-09-17 |
| INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery Impella 5.5 SmartAssist - Heart Failure, Cardiogenic Shock | Not applicable | Recruiting | Abiomed Inc. | 250 | 2026-10-02 | 2026-10-13 |
| RELIEVE-HFrEF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure With Reduced EF Implantation of the V-Wave Interatrial shunt, Sham (no implant) - Heart Failure and Reduced Ejection Fraction, Heart Failure Chronic | Not applicable | Not yet recruiting | V-Wave Ltd | 250 | 2026-09-30 | 2026-07-10 |
| Short-Term Outcomes of HFrEF Patients on Guideline-Directed Medical Therapy Heart Failure, Heart Failure, Systolic | Not yet recruiting | Assiut University | 250 | 2026-09-10 | 2026-09-17 | |
| Wearable Device-Assisted Remote Management to Improve Prognosis in Patients With Acute Heart Failure Complicated by Atrial Fibrillation: WARM-HF Trial (Stage 2) wearable device based remote management (GDMT titration for HF, rhythm control and anticoagulation management for AF) - Atrial Fibrillation (AF), Heart Failure and Reduced Ejection Fraction | Not applicable | Not yet recruiting | Beijing Anzhen Hospital | 818 | 2026-09-01 | 2026-07-09 |
| A Study of LY3971297 in Participants With Heart Failure LY3971297, Placebo - Heart Failure, Heart Failure, Diastolic | Phase 1 | Recruiting | Eli Lilly and Company | 90 | 2026-08-11 | 2026-09-22 |
| Heart Failure and Postoperative Outcome in Surgery - a National Registry Study Heart Failure, Diastolic Heart Failure | Not yet recruiting | Umeå University | 2200000 | 2026-08-01 | 2026-06-09 | |
| Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With Obesity Tirzepatide, Placebo - Heart Failure and Reduced Ejection Fraction, Obesity & Overweight | Phase 3 | Not yet recruiting | Shahid Beheshti University of Medical Sciences | 60 | 2026-07-18 | 2026-08-03 |
| HeartMate App-Based Remote Monitoring for Cardiovascular Risk Factor Management HeartMate App-Based Remote Cardiac Rehabilitation Program, Usual Care with HeartMate App-Based rPPG Measurement Only - Cardiovascular Diseases, Heart Failure, Systolic | Not applicable | Not yet recruiting | Yonsei University | 200 | 2026-07-14 | 2026-07-23 |
| Comparative Effects of Different Inspiratory Muscle Training Modalities in Patients With Heart Failure. Mechanical Pressure-Threshold IMT Device, PowerBreathe KH2 Electronic IMT Device, Sub-therapeutic Mechanical IMT Device (Sham) - Heart Failure, Heart Failure and Reduced Ejection Fraction | Not applicable | Enrolling by invitation | Universidad Nacional Andres Bello | 60 | 2026-06-17 | 2026-07-07 |
| Evaluation of Accelerated Bachmann Bundle Area Pacing in Heart Failure With Reduced ejectIon Fraction Who Have electrocarDioGraphic Evidence of Interatrial Block and Indicated for Implantable Cardioverter Defibrillator BBAP on, BBAP off, RAAP - Heart Failure and Reduced Ejection Fraction | Not applicable | Not yet recruiting | Seoul National University Hospital | 120 | 2026-05-01 | 2026-04-23 |
| Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure Notification Group, No Notification Group - Iron Deficiency (ID), Heart Failure | Not applicable | Recruiting | Kaiser Permanente | 400 | 2026-04-20 | 2026-10-01 |
| Selenium Intervention Registry Randomized Trial in Heart Failure Selenium Supplement, Placebo - Heart Failure, Heart Failure and Reduced Ejection Fraction | Phase 3 | Recruiting | Skane University Hospital | 4326 | 2026-04-01 | 2026-04-22 |
| Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With Reduced Ejection Fraction With Limited Kidney Function Assessments Blinded kidney function assessments - Heart Failure, Heart Failure and Reduced Ejection Fraction | Not applicable | Not yet recruiting | University Medical Center Groningen | 344 | 2026-04-01 | 2025-12-18 |
| ASCs in Recently Diagnosed Non-ischemic Heart Failure Allogeneic adipose tissue-derived mesenchymal stem cells, Cryostor CS10 - Non-Ischemic Heart Failure, Reduced Ejection Fraction Heart Failure | Phase 2 | Withdrawn | Cell to Cure ApS | 2026-03-01 | 2026-04-01 | |
| Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App) beta blockers, StudyU Application - HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 5 | 2026-02-10 | 2026-02-19 |
| Digoxin After Acute Heart Failure (DIG-DICA) Usual Care, Digoxin - Acute Heart Failure (AHF) | Phase 4 | Recruiting | Hospital General de Agudos "Dr. Cosme Argerich" | 120 | 2025-12-16 | 2026-06-02 |
| Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension JK07 - HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 2 | Withdrawn | Salubris Biotherapeutics Inc | 2025-12-15 | 2026-05-15 | |
| Personalized IoT-based Physical Activity Monitoring System for Heart Failure Patients Device&behavioral - Heart Failure, Reduced Ejection Fraction Heart Failure | Not applicable | Not yet recruiting | Abant Izzet Baysal University | 82 | 2025-12-13 | 2025-09-12 |
| PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure HAI-HF: Adenosine Stress [¹⁵O]H₂O PET Imaging, Two different doses of adenosine - Heart Failure and Reduced Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Gødstrup Hospital | 180 | 2025-12-08 | 2025-12-26 |
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Heart Failure (115) · Heart Failure, Diastolic (34) · Cardiovascular Diseases (13) · Atrial Fibrillation (12) · Ventricular Dysfunction, Left (12) · Heart Diseases (9) · Myocardial Infarction (8) · Iron Deficiencies (7) · Myocardial Ischemia (7) · Bundle-Branch Block (6) · Coronary Artery Disease (6) · Motor Activity (6) · Arrhythmias, Cardiac (5) · Depression (5)
Heart Diseases (213) · Cardiovascular Diseases (209) · Heart Failure (107) · Pathological Conditions, Signs and Symptoms (59) · Pathologic Processes (48) · Vascular Diseases (22) · Arrhythmias, Cardiac (21) · Nutritional and Metabolic Diseases (17) · Behavior (15) · Metabolic Diseases (14) · Signs and Symptoms (12) · Ventricular Dysfunction (12) · Cardiac Conduction System Disease (11) · Myocardial Ischemia (11) · Infarction (9)
sacubitril and valsartan sodium hydrate drug combination (10) · Valsartan (6) · ferric carboxymaltose (5) · Cardiac Resynchronization Therapy (4) · Enalapril (4) · dapagliflozin (4) · Blood Specimen Collection (3) · Echocardiography (3) · Sodium Chloride (3) · sacubitril (3) · Angiotensin Receptor Antagonists (2) · Bisoprolol (2) · Digoxin (2) · Exercise (2) · Interleukin 1 Receptor Antagonist Protein (2)
Novartis Pharmaceuticals (6) · University of Leeds (5) · Virginia Commonwealth University (5) · University of Colorado, Denver (4) · Aarhus University Hospital (3) · Herlev and Gentofte Hospital (3) · Oslo University Hospital (3) · Abbott Medical Devices (2) · AstraZeneca (2) · BioCardia, Inc. (2) · Bispebjerg Hospital (2) · Boston Scientific Corporation (2) · Chang Gung Memorial Hospital (2) · German Heart Institute (2) · Henrik Wiggers (2)
United States (82) · United Kingdom (15) · Denmark (14) · Germany (11) · Canada (9) · Brazil (8) · Italy (8) · Sweden (8) · China (7) · Poland (7) · South Korea (7) · Netherlands (6) · France (5) · Norway (5) · Taiwan (5)
Alan J Bank, MD (2) · Amit Noheria, MBBS, SM (2) · Carl Pepine, MD (2) · Daniel D Matlock, MD, MPH (2) · Kenneth C Bilchick, MD (2) · Kevin D O'Brien, MD (2) · Klaus Witte, MD (2) · Michael Zile, MD (2) · Rasmus Borgquist, MD PhD (2) · Abbas A Qayyum, MD MSc PhD (1) · Adam DeVore, MD, MHS (1) · Ahran D Arnold, MBBS, BSc, MSc, MRCP, PhD (1) · Ajit Singh, PHARM D, PhD (1)
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1UM1TR004538-01 (1), 2015 (1), 2016 (1), 2018 (1), 2025 (1), R01HL136403 (1), R01HL144937 (1), R01HL168752 (1), R01HL173578 (1), R03AG064371 (1), R21AG075639 (1), R21HL126209 (1)