1805 completed, 751 unknown, 465 recruiting, 239 not yet recruiting. 1649 Not applicable, 345 Phase 4, 256 Phase 3, 165 Phase 2, 51 Phase 1.
Follow Atrial Fibrillation: new trials by email Literature Review of Atrial Fibrillation trials Research Report on Atrial Fibrillation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Standalone Thoracoscopic Left Atrial Appendage Closure Versus Medical Therapy in Atrial Fibrillation Video-assisted thoracoscopic closure of the left atrial appendage using a closure device and discontinuation of treatment if the patient is treated with OAC - ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Oral Anticoagulation | Not applicable | Not yet recruiting | Region Skane | 936 | 2028-01-01 | 2026-07-15 |
| Study to Evaluate the effIcacy and Safety of Abelacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral Anticoagulation Abelacimab - Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | Novartis Pharmaceuticals | 2500 | 2027-12-30 | 2026-07-31 |
| Conscious Sedation Study CLAAS® System - Atrial Fibrillation | Not applicable | Not yet recruiting | Conformal Medical, Inc | 300 | 2027-08-01 | 2026-03-20 |
| Registry on Luma Vision's VERAFEYE System (ENLIgHT) VERAFEYE System - Atrial Fibrillation, Left Atrial Appendage Closure | Not yet recruiting | LUMA Vision Ltd. | 50 | 2027-05-15 | 2026-09-15 | |
| The Effectiveness of Patch-Based Screening for Pre-Symptomatic Atrial Fibrillation to Improve Patient Outcome Zio XT® Patch - Atrial Fibrillation | Not applicable | Not yet recruiting | VA Office of Research and Development | 24060 | 2027-03-08 | 2026-06-30 |
| OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation Oral anticoagulation, Single antiplatelet therapy - Atrial Fibrillation (AF), Coronary Artery Disease | Phase 4 | Not yet recruiting | Ewha Womans University Mokdong Hospital | 2 | 2027-03-01 | 2026-03-27 |
| WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale | Not applicable | Not yet recruiting | Luciano A. Sposato | 2400 | 2027-03-01 | 2026-09-18 |
| Lattice vs Pentaspline Comparative Evaluation in Persistent AF Pulmonary vein isolation - Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | Mitera Hospital | 250 | 2027-03-01 | 2026-09-15 |
| AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure Exercise training - HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation | Not applicable | Recruiting | Technical University of Munich | 40 | 2027-02-01 | 2026-09-18 |
| Alert-HF: Early Detection and Intervention on Atrial Fibrillation in Heart Failure Patients Implantable loop recorder, Patient-driven portable ECG monitoring, Usual Care - Heart Failure | Phase 4 | Not yet recruiting | Medisch Spectrum Twente | 258 | 2027-01-01 | 2026-09-11 |
| Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia | Phase 1 / Phase 2 | Not yet recruiting | Deeptankar DeMazumder | 208 | 2027-01-01 | 2026-01-22 |
| Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation) Verapamil Hydrochloride, Metoprolol tartrate - Atrial Fibrillation (AF), Atrial Fibrillation With Rapid Ventricular Response | Phase 4 | Not yet recruiting | Muhammad Ali Javed | 120 | 2027-01-01 | 2026-08-03 |
| Catheter Ablation Using a Novel Navigation and Imaging System VERAFEYE System - Paroxysmal Atrial Fibrillation | Not yet recruiting | LUMA Vision Ltd. | 100 | 2027-01-01 | 2026-09-15 | |
| An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF) | Not yet recruiting | Ewha Womans University Mokdong Hospital | 1000 | 2027-01-01 | 2026-07-20 | |
| Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery Amiodarone - Surgery, Cardiac, Atrial Fibrillation | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 242 | 2027-01-01 | 2026-06-30 |
| Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy. Colchicine, Amiodarone, Posterior pericardiotomy - Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | Elsan | 636 | 2027-01-01 | 2026-10-21 |
| Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG digital single-channel ECG recording - Atrial Fibrillation, Atrioventricular Block, Second and Third Degree | Not yet recruiting | I.M. Sechenov First Moscow State Medical University | 300 | 2026-12-31 | 2026-02-10 | |
| Computerized Decision Support to Prevent Stroke in Atrial Fibrillation Alert-based computerized decision support - Atrial Fibrillation, Stroke | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 2500 | 2026-12-30 | 2026-02-25 |
| Left Atrial Appendage Occlusion in Dialysis Patients With Atrial Fibrillation: A Multicentre Pilot Study Dialysis, Chronic Kidney Disease (Stages 3b-5) | Not yet recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 40 | 2026-12-05 | 2026-09-16 | |
| Evaluation of the Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal Atrial Fibrillation Globe Pulsed Field System - Paroxysmal Atrial Fibrillation | Not applicable | Not yet recruiting | Kardium Inc. | 250 | 2026-12-01 | 2026-07-20 |
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Stroke (339) · Arrhythmias, Cardiac (309) · Heart Failure (206) · Atrial Flutter (151) · Ischemic Stroke (120) · Cardiovascular Diseases (100) · Coronary Artery Disease (79) · Heart Diseases (79) · Hypertension (78) · Hemorrhage (66) · Venous Thrombosis (54) · Myocardial Infarction (53) · Tachycardia, Ventricular (53) · Pulmonary Embolism (47)
Pathological Conditions, Signs and Symptoms (3821) · Pathologic Processes (3807) · Heart Diseases (3742) · Cardiovascular Diseases (3721) · Arrhythmias, Cardiac (3512) · Vascular Diseases (754) · Nervous System Diseases (524) · Central Nervous System Diseases (457) · Brain Diseases (456) · Cerebrovascular Disorders (443) · Embolism and Thrombosis (159) · Cardiac Conduction System Disease (149) · Myocardial Ischemia (149) · Respiratory Tract Diseases (124) · Nutritional and Metabolic Diseases (102)
Catheter Ablation (146) · Rivaroxaban (114) · Warfarin (109) · apixaban (83) · Dabigatran (81) · Amiodarone (68) · Radiofrequency Ablation (59) · edoxaban (56) · Left Atrial Appendage Closure (37) · Aspirin (34) · Standard of Care (31) · Dronedarone (29) · Electric Countershock (28) · Flecainide (28) · Clopidogrel (26)
Abbott Medical Devices (64) · Boston Scientific Corporation (63) · Bayer (59) · Biosense Webster, Inc. (50) · Yonsei University (48) · Boehringer Ingelheim (45) · Beijing Anzhen Hospital (34) · Medtronic Cardiac Ablation Solutions (32) · Medtronic Cardiac Rhythm and Heart Failure (32) · Mayo Clinic (30) · Meshalkin Research Institute of Pathology of Circulation (29) · Population Health Research Institute (27) · Shanghai Chest Hospital (27) · The Cleveland Clinic (25) · Barts & The London NHS Trust (23)
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Andrea Natale, MD (26) · Vivek Reddy, MD (24) · Dhanunjaya Lakkireddy, MD (16) · Biosense Webster, Inc. Clinical Trial (13) · Atul Verma, MD (12) · Khaldoun Tarakji, MD (8) · Dhanunjaya Lakkireddy (7) · Isabel Deisenhofer, MD (7)
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