Heart Failure: Clinical Trials

2951 completed, 994 unknown, 708 recruiting, 431 terminated. 2333 Not applicable, 601 Phase 2, 448 Phase 4, 434 Phase 3, 304 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	2333	Completed 1152, Unknown 359, Recruiting 290, Terminated 163, Not yet recruiting 135, Withdrawn 102, Active not recruiting 97, Enrolling by invitation 28, Suspended 7
Phase 2	601	Completed 336, Unknown 77, Terminated 76, Recruiting 45, Withdrawn 33, Not yet recruiting 16, Active not recruiting 12, Suspended 4, Enrolling by invitation 2
Phase 4	448	Completed 229, Unknown 86, Terminated 53, Recruiting 33, Withdrawn 21, Active not recruiting 10, Not yet recruiting 10, Enrolling by invitation 5, Suspended 1
Phase 3	434	Completed 243, Unknown 59, Terminated 55, Recruiting 42, Not yet recruiting 13, Withdrawn 10, Active not recruiting 8, Suspended 3, Enrolling by invitation 1
Phase 1	304	Completed 173, Unknown 39, Recruiting 27, Terminated 26, Withdrawn 21, Not yet recruiting 8, Active not recruiting 6, Suspended 3, Enrolling by invitation 1
Early Phase 1	37	Completed 21, Recruiting 4, Unknown 4, Withdrawn 3, Not yet recruiting 2, Terminated 2, Active not recruiting 1

Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction Heart Failure, Preserved Ejection Fraction		Not yet recruiting	Boehringer Ingelheim	3000	2028-01-31	2026-09-16
Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy	Phase 3	Not yet recruiting	Carelon Research	25	2027-08-01	2026-09-14
This Will be a Randomized Comparison of the Proteomic Effects of Vicadrostat/Empagliflozin Versus Empagliflozin and Versus Empagliflozin/Spironolactone in Heart Failure Patients With Preserved Ejection Fraction empa plus vica, Comparator: empa 10 plus spironolactone - Heart Failure With Preserved Ejection Fraction (HFPEF)	Phase 2	Not yet recruiting	Baim Institute for Clinical Research	200	2027-03-01	2026-10-05
A Comparison of Left Bundle Branch Optimized Cardiac Resynchronization Therapy vs Left Bundle Branch Area Pacing Alone LOT-CRT-P (Programming: LBBAP), LOT-CRT-P (Programming: LOT-CRT-P) - Heart Failure, Left Bundle Branch Area Pacing	Not applicable	Not yet recruiting	PD Dr. Guram Imnadze	124	2027-02-01	2026-09-25
Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation tVNS session on the left earlobe, tVNS "SHAM" session the conchae aurea of the left ear - Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA)	Not applicable	Not yet recruiting	Centre Hospitalier Universitaire de Saint Etienne	64	2027-01-31	2026-10-23
A First-in-Human Study to Evaluate the Safety and Efficacy of Left Ventricular Assist Device Combined With Exosome Therapy for Patients With Heart Failure（RESTORATION） Exosome Preparation, Placebo - Heart Failure	Early Phase 1	Not yet recruiting	Yining Yang	24	2027-01-15	2026-10-20
Testing Heart Failure Resilience Intervention for Caregivers (HEROIC) in Advanced Heart Failure HEROIC program, Active Comparator Control 1 - Heart Failure, Caregiver	Phase 2	Not yet recruiting	Johns Hopkins University	500	2027-01-04	2026-09-04
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure	Not applicable	Not yet recruiting	Duke University	450	2027-01-01	2026-07-08
Alert-HF: Early Detection and Intervention on Atrial Fibrillation in Heart Failure Patients Implantable loop recorder, Patient-driven portable ECG monitoring, Usual Care - Heart Failure	Phase 4	Not yet recruiting	Medisch Spectrum Twente	258	2027-01-01	2026-09-11
SWedish Intensive Care Biobank Any Condition Underlying Critical Illness		Not yet recruiting	Uppsala University	25000	2027-01-01	2026-05-13
Heart Failure Self Care Education in Rwanda HF Education - Heart Failure	Not applicable	Not yet recruiting	Boston Medical Center	400	2027-01-01	2026-09-30
Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO Low anticoagulation dose of argatroban and enoxaparin during ECMO, Standard anticoagulation dose of argatroban and enoxaparin during ECMO - Pneumonia, Heart Failure	Phase 2	Not yet recruiting	University Hospital Ostrava	200	2027-01-01	2026-04-02
Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study Tricuspid Regurgitation, Heart Failure		Enrolling by invitation	Columbia University	140	2027-01-01	2026-02-12
Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia	Phase 1 / Phase 2	Not yet recruiting	Deeptankar DeMazumder	208	2027-01-01	2026-01-22
Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE Ultrasound-facilitated, catheter-directed lower-dose fibrinolysis, Tissue Plasminogen Activator - Pulmonary Embolism, Right Ventricular Dysfunction		Suspended	Brigham and Women's Hospital	60	2027-01-01	2026-01-21
GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry GLP-1 / GIP receptor agonist - Heart Failure With Preserved Ejection Fraction, Obesity		Not yet recruiting	Miedziowe Centrum Zdrowia SA	150	2027-01-01	2026-08-26
Wearable Technology in Heart Failure Patients Heart Failure		Not yet recruiting	The Cleveland Clinic	500	2027-01-01	2026-09-28
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes		Recruiting	Bettina Mittendorfer	100	2027-01-01	2026-05-07
A Study of the Effect of a Nurse Navigator Program on High Risk Patients Nurse Navigator Program - Patient Readmission, Arthroplasty, Replacement, Knee	Not applicable	Not yet recruiting	Mayo Clinic	300	2027-01-01	2026-03-19
Feasibility and Acceptability of Three Component Intervention for the Heart Failure Care for Rural Dwelling Participants Video Based Visits, Remote Self-Care Education, Remote Patient Monitoring - Heart Failure	Not applicable	Not yet recruiting	University of Alabama at Birmingham	32	2027-01-01	2026-01-27

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Narrower conditions

Cardiovascular Diseases (299)  ·  Heart Diseases (222)  ·  Heart Failure, Systolic (222)  ·  Atrial Fibrillation (220)  ·  Pulmonary Disease, Chronic Obstructive (202)  ·  Heart Failure, Diastolic (198)  ·  Myocardial Infarction (186)  ·  Cardiomyopathies (183)  ·  Hypertension (175)  ·  Diabetes Mellitus (172)  ·  Coronary Artery Disease (146)  ·  Arrhythmias, Cardiac (135)  ·  Motor Activity (130)  ·  Stroke (119)

Broader conditions

Heart Diseases (5638)  ·  Cardiovascular Diseases (5561)  ·  Pathological Conditions, Signs and Symptoms (1624)  ·  Pathologic Processes (1275)  ·  Vascular Diseases (823)  ·  Respiratory Tract Diseases (590)  ·  Nutritional and Metabolic Diseases (466)  ·  Myocardial Ischemia (449)  ·  Signs and Symptoms (440)  ·  Metabolic Diseases (410)  ·  Lung Diseases (389)  ·  Urogenital Diseases (376)  ·  Female Urogenital Diseases and Pregnancy Complications (366)  ·  Disease Attributes (365)  ·  Nervous System Diseases (363)

Interventions

sacubitril and valsartan sodium hydrate drug combination (83)  ·  Cardiac Resynchronization Therapy (73)  ·  Exercise (69)  ·  dapagliflozin (62)  ·  Furosemide (58)  ·  Standard of Care (58)  ·  empagliflozin (54)  ·  Echocardiography (48)  ·  Spironolactone (46)  ·  Valsartan (39)  ·  Natriuretic Peptide, Brain (37)  ·  Carvedilol (33)  ·  Simendan (33)  ·  Blood Specimen Collection (31)  ·  Defibrillators, Implantable (29)

Sponsors

Abbott Medical Devices (105)  ·  Medtronic Cardiac Rhythm and Heart Failure (98)  ·  Mayo Clinic (65)  ·  Duke University (59)  ·  AstraZeneca (56)  ·  Boston Scientific Corporation (52)  ·  National Heart, Lung, and Blood Institute (NHLBI) (48)  ·  Novartis Pharmaceuticals (47)  ·  Brigham and Women's Hospital (39)  ·  VA Office of Research and Development (39)  ·  Massachusetts General Hospital (36)  ·  Biotronik SE & Co. KG (34)  ·  University of Pennsylvania (34)  ·  Bayer (32)  ·  Yale University (32)

Countries

United States (2048)  ·  Germany (556)  ·  United Kingdom (456)  ·  Canada (430)  ·  Italy (414)  ·  France (397)  ·  Spain (307)  ·  China (299)  ·  Netherlands (285)  ·  Poland (247)  ·  Denmark (217)  ·  Brazil (193)  ·  Belgium (180)  ·  Sweden (164)  ·  Australia (158)

Top investigators

Eugene Braunwald, MD (10)  ·  William Abraham, MD (8)  ·  Dalane W Kitzman, MD (7)  ·  Henry Krum, MBBS FRACP PhD (7)  ·  Jeffrey Testani, MD (7)  ·  William T Abraham, MD (7)  ·  Marco Metra, MD (6)

Results publications

PMID 31081589, PMID 34447992, PMID 34693515, PMID 37366061, PMID 27206819, PMID 31535829, PMID 33107592, PMID 38770818, PMID 23636237, PMID 29098321, PMID 30303894, PMID 32150314, PMID 36632831, PMID 40223608, PMID 10758967, PMID 17666313, PMID 18946063, PMID 19196892, PMID 20024643, PMID 22772084, PMID 22936827, PMID 23616602, PMID 23900696, PMID 24678999, PMID 25176015, PMID 25326006, PMID 25527757, PMID 25593120, PMID 25982108, PMID 26011593, PMID 26038537, PMID 26041600, PMID 26124205, PMID 26354543, PMID 26378978, PMID 26823498, PMID 29314424, PMID 29431256, PMID 30057766, PMID 30586701, PMID 30592353, PMID 31370950, PMID 32222134, PMID 32605387, PMID 32865377, PMID 33301080, PMID 33501848, PMID 33902478, PMID 34270325, PMID 34465123

NIH funding

2023 (25), 2016 (23), 2025 (16), 2019 (15), 2017 (13), 2015 (12), 2018 (12), 2014 (10), 2009 (9), U01HL084904 (6), P01HL076611 (5), R01HL084155 (5), 2005 (4), P50HL077096 (4), U10HL084904 (4)