31 completed, 20 recruiting, 17 unknown, 13 terminated. 51 Not applicable, 5 Phase 4, 1 Phase 2, 1 Phase 3.
Follow Bundle-Branch Block: new trials by email Literature Review of Bundle-Branch Block trials Research Report on Bundle-Branch Block
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP) - Bradycardia, Atrioventricular Block | Not applicable | Not yet recruiting | Yonsei University | 300 | 2026-10-01 | 2026-09-04 |
| REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints Physiologic cardiac resynchronization using conduction system pacing and selective LV lead optimization. - Heart Failure - NYHA II - IV, Left Bundle Branch Area Pacing | Not yet recruiting | University of Pecs | 50 | 2026-06-29 | 2026-07-10 | |
| Machine Learning for Diagnosis of Occlusive MI in LBBB Patients Digital 12-Lead ECG Analysis and Invasive Coronary Angiography - Acute Myocardial Infarction (AMI), Left Bundle Branch Block | Recruiting | Konya City Hospital | 50 | 2026-06-01 | 2026-06-02 | |
| Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up Pacemaker lead - Bradycardia, Atrioventricular Block | Recruiting | Boston Scientific Corporation | 140 | 2025-12-19 | 2026-10-07 | |
| A Multimodal Strategy to Screen for and Rule-Out Delayed High-Grade Conduction Disturbances After TAVR retrospective health data collection - Transcatheter Aortic Valve Implantation, Permanent Pacemaker Implantation | Completed | University Hospital, Montpellier | 209 | 2025-09-23 | 2026-05-22 | |
| Pain Relief and and Peripheral Perfusion Index During Erector Spinae Block Erector Spinae Plane Block - Block, Block, Fascicular | Not applicable | Completed | Keimyung University Dongsan Medical Center | 90 | 2025-05-13 | 2026-01-09 |
| Novel Approach to Conduction System Pacing With Use of Ultrasound Ultrasound guidance, Fluoroscopy guided - Conduction Block, Atrioventricular, Bundle-Branch Block | Not applicable | Recruiting | Habib Khan | 152 | 2025-04-10 | 2026-10-19 |
| THE RELATIONSHIP BETWEEN CARDIAC RESYNCHRONİZATION THERAPY RESPONSE IN HEART FAILURE PATIENTS AND YKL-40 LEVELS Hearth Failure With Reduced Ejection Fraction (HFrEF), Cardiac Resynchronisation Therapy (CRT) | Active not recruiting | Trakya University | 51 | 2025-03-01 | 2026-03-13 | |
| EArly Effect of Glucocorticoid on Incidence of Persistent Left BundlE Branch Block (LBBB) Post-TAVR (EAGLE-TAVR Trial) Methylprednisolone (Corticosteroid), Placebo - Transcatheter Aortic Valve Replacemen, Left Bundle Branch Block | Phase 4 | Not yet recruiting | Xiao-dong Zhuang | 200 | 2025-01-01 | 2025-01-07 |
| Management of Patients With New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation Transcatheter Aortic Valve Implantation - Left Bundle-Branch Block | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 360 | 2024-11-12 | 2025-07-01 |
| Left Bundle Branch Pacing on Outcomes and Ventricular Remodeling in Biventricular CRT Nonresponders Cardiac Resynchronization Therapy Devices with Defibrillator Function (CRT-D) or CRT-D Leads Replacement, CRT-D or CRT-D Leads Replacement with New Lead Implantation to Left Bundle Branch and Inactivation of Conventional Right and Left Ventricular Pacing, CRT-D or CRT-D Leads Replacement with New Lead Implantation to Left Bundle Branch and Inactivation of Conventional Right Ventricular Pacing - Heart Failure, Left Bundle-Branch Block | Not applicable | Recruiting | Tomsk National Research Medical Center of the Russian Academy of Sciences | 30 | 2024-11-01 | 2024-11-22 |
| Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right) Pacemaker Interrogation and Electrocardiogram (ECG):, Cardiopulmonary Exercise Test (CPET) and Exercise Stress Cardiac Magnetic Resonance (ExeCMR, Continuous pacemaker telemetry (CPT) - Left Branch Bundle Block, RV - Right Ventricular Abnormality | Not applicable | Completed | Virginia Commonwealth University | 5 | 2024-08-23 | 2026-08-12 |
| Left Bundle Branch Area Pacing in Patients With Heart Failure left bundle branch area pacing - Heart Failure With Reduced Ejection Fraction, Left Bundle Branch Area Pacing | Not applicable | Unknown | National Research Center for Cardiac Surgery, Kazakhstan | 50 | 2024-06-01 | 2024-07-05 |
| UHF ECG in LBBB and Response to CRT Prediction LBBAP CRT device implantation, BVP-CRT - Left Bundle Branch Block, Left Bundle Branch Area Pacing | Not applicable | Recruiting | Faculty Hospital Kralovske Vinohrady | 200 | 2024-05-01 | 2025-07-14 |
| Clinical Efficacy and Safety of Left Bundle Branch Area Pacing Using Quantitative Guidance of Multimodal Data in the Treatment of Heart Failure Apply multimodal data fusion for quantitative guidance of left bundle branch region pacing, Conventional Biventricular Pacing - Heart Failure, Left Bundle Branch Block | Not applicable | Recruiting | Second Affiliated Hospital of Nanchang University | 100 | 2024-03-01 | 2026-09-11 |
| Improving CRT Outcome With Non-Invasive Cardiac Mapping Pre-implantation planning, Post-implantation assessment - Heart Failure With Reduced Ejection Fraction | Not applicable | Recruiting | EP Solutions SA | 330 | 2023-12-20 | 2025-08-07 |
| HIS Alternative II - UK Site HIS/LBB pacing, LV pacing - Heart Failure, Left Bundle-Branch Block | Not applicable | Unknown | Imperial College Healthcare NHS Trust | 40 | 2023-12-01 | 2024-04-05 |
| Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation Prophylactic pacemaker implantation - Aortic Stenosis, Right Bundle-Branch Block | Not applicable | Not yet recruiting | Aalborg University Hospital | 320 | 2023-12-01 | 2023-06-05 |
| A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software Chang Gung ECG Abnormality Detection Software - Long QT Syndrome, Sinus Bradycardia | Unknown | Chang Gung Memorial Hospital | 4306 | 2023-10-06 | 2024-01-11 | |
| Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Biventricular Pacing, Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Left Bundle Branch Pacing - Heart Failure, Left Bundle-Branch Block | Not applicable | Recruiting | Tomsk National Research Medical Center of the Russian Academy of Sciences | 60 | 2023-10-01 | 2025-09-10 |
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Heart Failure (43) · Atrioventricular Block (12) · Aortic Valve Stenosis (8) · Heart Failure, Systolic (6) · Ventricular Dysfunction, Left (5) · Arrhythmias, Cardiac (4) · Bradycardia (4) · Cardiomyopathies (4) · Ventricular Remodeling (3) · Aortic Valve, Calcification of (2) · Atrial Fibrillation (2) · Atrial Flutter (2) · Atrial Premature Complexes (2) · Bites and Stings (2)
Cardiac Conduction System Disease (92) · Cardiovascular Diseases (92) · Pathologic Processes (92) · Pathological Conditions, Signs and Symptoms (92) · Heart Diseases (91) · Heart Block (90) · Arrhythmias, Cardiac (88) · Aortic Valve Disease (8) · Heart Valve Diseases (8) · Ventricular Outflow Obstruction (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Ventricular Dysfunction (5) · Pathological Conditions, Anatomical (4) · Cardiomegaly (3) · Cardiomyopathies (3)
Cardiac Resynchronization Therapy (9) · Transcatheter Aortic Valve Replacement (4) · Exercise Test (3) · Methylprednisolone (2) · Adrenal Cortex Hormones (1) · Adrenergic beta-Antagonists (1) · Cardiac Resynchronization Therapy Devices (1) · Catheterization, Peripheral (1) · Clostridium perfringens epsilon-toxin (1) · Device Lead Extraction (1) · Drug Implants (1) · Echocardiography (1) · Electrocardiography (1) · Lidocaine (1) · Magnetic Resonance Imaging (1)
Boston Scientific Corporation (3) · Copenhagen University Hospital, Rigshospitalet (3) · Maastricht University Medical Center (3) · Abbott Medical Devices (2) · Duke University (2) · Imperial College London (2) · Institut für Pharmakologie und Präventive Medizin (2) · Medtronic Cardiac Rhythm and Heart Failure (2) · Tomsk National Research Medical Center of the Russian Academy of Sciences (2) · University Medical Centre Ljubljana (2) · University of Aarhus (2) · Aalborg University Hospital (1) · Aarhus University Hospital (1) · Amsterdam UMC, location VUmc (1) · Ashkan Eftekhari (1)
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Ashkan Eftekhari (2) · Kevin Vernooy, MD, PhD (2) · Roman E Batalov, M.D. (2) · Tariel A Atabekov, Ph.D. (2) · Tobias Geisler, Prof. (2) · Ajay Pillai (1) · Alexander Dal Forno, MD (1) · Alexander T Limkakeng, MD (1) · Amit Noheria, MBBS, SM (1) · Andre Zimerman, MD PhD (1) · Andrew Redington, MD, DMSc, Prof. (1) · Angelo Auricchio, MD PhD FESC (1) · Anja Zupan Meznar, MD (1) · Anthony WC Chow, MBBS BSc MD (1)
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