40 completed, 8 recruiting, 8 terminated, 8 unknown. 17 Not applicable, 17 Phase 3, 14 Phase 2, 9 Phase 1, 8 Phase 4.
Follow Adenosine: new trials by email Literature Review of Adenosine trials Research Report on Adenosine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reducing Slow/No-Reflow With Prophylactic High-Dose Intracoronary Adenosine Protocol in ST-Elevation Myocardial Infarction The REFLOW AMI Trial Adenosine, Standard Treatment only - ST-Elevation Myocardial Infarction (STEMI) | Not applicable | Recruiting | Prof Muzaffar Ali Zahidi | 660 | 2026-08-14 | 2026-10-27 |
| Adenosine vs Diltiazem for Treatment of SVT in the ED adenosine, diltiazem - Supraventricular Tachycardia (SVT) | Phase 4 | Recruiting | Anne E. Zepeski | 20 | 2025-08-01 | 2026-05-28 |
| PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department IV adenosine, IV diltiazem - Supraventricular Tachycardia (SVT) | Recruiting | University of Iowa | 100 | 2025-04-04 | 2026-08-21 | |
| Efficacy of Adenosine as Compared to Verapamil in Paroxysmal Supraventricular Tachycardia (pSVT) Patients Adenosine, Verapamil Injection - Supraventricular Tachycardia (SVtach) | Phase 3 | Recruiting | Rashid Latif Medical College | 210 | 2024-10-28 | 2024-12-13 |
| Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses Adenosine - Chronic Coronary Syndrome, Coronary Artery Disease | Phase 4 | Recruiting | Region Skane | 180 | 2024-10-23 | 2026-08-13 |
| The ARCTIC Trial: Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19 Adenosine - Acute Respiratory Distress | Phase 2 | Withdrawn | University of Florida | 2023-12-01 | 2024-05-06 | |
| Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction Adenosine - Myocardial Ischemia | Phase 3 | Withdrawn | Vastra Gotaland Region | 2023-01-01 | 2024-05-17 | |
| Adrenaline for the Treatment of No-Reflow in Normotensive Patients Adrenaline, Adenosine - Acute Coronary Syndrome, No-Reflow Phenomenon | Phase 4 | Completed | National Institute of Cardiovascular Diseases, Pakistan | 201 | 2021-01-01 | 2021-05-21 |
| BROKEN-SWEDEHEART- Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome. Adenosine, Dipyridamole 200 mg, Apixaban 5 mg Oral Tablet - Takotsubo Syndrome | Phase 4 | Recruiting | Vastra Gotaland Region | 1000 | 2020-12-14 | 2024-12-02 |
| The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties. Adenosine, Saline - Headache, Migraine | Not applicable | Completed | Danish Headache Center | 18 | 2020-11-01 | 2022-11-16 |
| Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting adenosine, verapamil - Supraventricular Tachycardia | Not applicable | Completed | Ain Shams University | 268 | 2020-02-01 | 2020-12-02 |
| Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults Adenosine Triphosphate, Acetylcholine, Sodium Nitroprusside - Receptor Blockade | Early Phase 1 | Completed | Colorado State University | 9 | 2019-02-07 | 2021-07-27 |
| Adenosine Contrast CorrELations in Evaluating RevAscularizaTION Iopamidol, adenosine, Navvus® Catheter - Percutaneous Coronary Intervention | Phase 4 | Completed | Duke University | 201 | 2019-01-17 | 2024-07-05 |
| A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction Bivalirudin, Adenosine, Heparin - Coronary Microvascular Disease, Ischemic Heart Disease | Not applicable | Active not recruiting | NYU Langone Health | 206 | 2018-06-29 | 2025-11-28 |
| Stress Test in Detecting Heart Damage in Premenopausal Women With Stage I-III Breast Cancer Adenosine, Magnetic Resonance Imaging, Regadenoson - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Completed | Wake Forest University Health Sciences | 25 | 2018-06-21 | 2026-01-29 | |
| Management of Supraventricular Tachycardia of Children adenosine,Propranolol,flecainide, amiodarone, propranolol, digoxin and procainamide. - Supraventricular Tachycardia | Unknown | Assiut University | 50 | 2018-05-15 | 2018-05-18 | |
| A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT) Adenosine - Supra-ventricular Tachycardia | Phase 3 | Completed | University of Pretoria | 30 | 2018-04-01 | 2021-06-25 |
| Whole-Heart Myocardial Blood Flow Quantification Using MRI Myocardial Perfusion Cardiac MRI., Contrast, Pharmacologic Stress Agent - Coronary Artery Disease, Coronary Microvascular Disease | Unknown | Cedars-Sinai Medical Center | 160 | 2018-03-01 | 2023-02-08 | |
| A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI SAR407899, Placebo, Adenosine - Microvascular Coronary Artery Disease | Phase 2 | Terminated | Sanofi | 10 | 2017-10-12 | 2022-03-24 |
| Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve Regadenoson, Adenosine - Hypertrophic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy | Phase 4 | Terminated | Duke University | 31 | 2017-09-05 | 2020-09-16 |
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Coronary Artery Disease (18) · Myocardial Ischemia (10) · Tachycardia, Supraventricular (7) · Ischemia (4) · Angina Pectoris (3) · Inflammation (2) · Microvascular Angina (2) · Obesity (2) · Reperfusion Injury (2) · Takotsubo Cardiomyopathy (2) · Acute Coronary Syndrome (1) · Acute Lung Injury (1) · Angina, Stable (1) · Atherosclerosis (1) · Atrial Fibrillation (1)
University of Utah (3) · Cedars-Sinai Medical Center (2) · Duke University (2) · Forest Laboratories (2) · Gilead Sciences (2) · Pfizer (2) · Radboud University Medical Center (2) · Vanderbilt University (2) · Vastra Gotaland Region (2) · Wake Forest University Health Sciences (2) · Adenobio N.V (1) · Ain Shams University (1) · Amphia Hospital (1) · Anne E. Zepeski (1) · Assiut University (1)
United States (33) · Netherlands (7) · Denmark (5) · Italy (5) · Sweden (4) · Belgium (3) · Pakistan (3) · Brazil (2) · Canada (2) · France (2) · Norway (2) · South Korea (2) · United Kingdom (2) · Argentina (1) · Austria (1)
David B Bharucha, MD, PhD, FACC (2) · Edward DiBella, Ph.D. (2) · Gerard Rongen, MD, PhD (2) · Italo Biaggioni, M.D. (2) · Robert L. Rolleri, Pharm.D. (2) · Anne Zepeski, PharmD (1) · B. Bravenboer, MD, PhD (1) · Brian B Ghoshhajra, MD (1) · Bruce Spiess (1) · Bryan Goldstein, MD (1) · Debiao Li, PhD (1) · Elmir Omerovic, MD PhD (1)
PMID 17826318, PMID 19744616, PMID 19936863, PMID 20093513, PMID 21196444, PMID 21697134, PMID 21968545, PMID 22000773, PMID 22146505, PMID 22210535, PMID 22222164, PMID 22964356, PMID 23051145, PMID 25136887, PMID 25449504, PMID 25977304, PMID 26068287, PMID 26242981, PMID 26577263, PMID 27013162, PMID 27101902, PMID 27282899, PMID 27435894, PMID 28086778, PMID 28450351, PMID 28728652, PMID 29042397, PMID 29050557, PMID 29361484, PMID 30115688, PMID 34335296, PMID 34503740, PMID 34503741, PMID 35000456, PMID 36251971, PMID 36435233, PMID 37264699, PMID 38583174, PMID 39234878, PMID 40270240, PMID 9426034
2008 (1), 2009 (1), 2015 (1), 2016 (1), 2023 (1), P01NS041386 (1), P30CA012197 (1), R01EB002623 (1), R01HL124649 (1), R01HL135328 (1)