667 completed, 302 unknown, 292 recruiting, 120 active not recruiting. 629 Not applicable, 81 Phase 4, 79 Phase 2, 70 Phase 3, 26 Phase 1.
Follow Aortic Valve Disease: new trials by email Literature Review of Aortic Valve Disease trials Research Report on Aortic Valve Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aficamten and Patient-Reported Outcomes in Real-World nHCM receiving aficamten - Hypertrophic Cardiomyopathy (HCM) | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2027-06-01 | 2026-09-29 | |
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation Aortic Stenosis, Mitral Regurgitation | Not yet recruiting | Josep Rodes-Cabau | 300 | 2027-01-05 | 2026-11-04 | |
| High Flow Nasal Oxygenation in Transcatheter Aortic Valve Replacement Procedures. TAVR-Highflow II Oxygen therapy during sedation provided via high nasal cannulae (60L/min at 60% FiO2), Oxygen therapy during sedation delivered via nasal cannulae at 5L/min - Aortic Stenosis Treated With TAVI, Sedation; Aged; Hemodynamics | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 452 | 2027-01-01 | 2026-09-18 |
| Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE) Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.) - Valvular Heart Disease Patients, Aortic Stenosis | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 1088 | 2026-12-15 | 2026-11-03 |
| A Prospective, Multi-centre, Single Arm, Pivotal Clinical Study to Determine the Safety and Effectiveness of Crea Aortic Valve for Use as a Replacement Aortic Heart Valve Investigational Transcatheter Aortic Valve Replacement System - Aortic Valve Stenosis, Severe Aortic Stenosis | Not applicable | Not yet recruiting | Onecrea Medical Inc. | 30 | 2026-12-04 | 2026-07-29 |
| Gradual Tapering or Discontinuation of Beta-Blockers After Stabilization With Mavacamten Therapy Beta-Blocker Sequential Tapering and Discontinuation, Beta-Blocker Baseline Stable-Dose Maintenance - Obstructive Hypertrophic Cardiomyopathy (oHCM) | Not applicable | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 286 | 2026-12-01 | 2026-09-11 |
| Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic Stenosis Dapagliflozin (DAPA), Spironolactone (drug), Spironolactone + Dapagliflozin - Aortic Stenosis | Phase 2 | Not yet recruiting | University College, London | 445 | 2026-12-01 | 2026-09-11 |
| Effect of Double-Tap Optimization on Valve Expansion and Hemodynamics in Balloon-expandable Transcatheter Aortic Valve Implantation: A Randomized Clinical Trial (DO-OPT TAVI Trial) Double-Tap Balloon Post-dilatation, Conventional Single-Inflation TAVI - Severe Aortic Stenosis | Not applicable | Not yet recruiting | Yonsei University | 250 | 2026-12-01 | 2026-11-03 |
| Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) Transcatheter Aortic Valve Replacement (TAVR) with surgical oversight, Transcatheter Aortic Valve Replacement (TAVR) without surgical oversight - Aortic Stenosis, Severe Aortic Stenosis | Phase 4 | Not yet recruiting | University of Alberta | 600 | 2026-12-01 | 2026-10-27 |
| Sparrow App Guided Evaluation (SAGE) Vanguard Trial for Aortic Stenosis in Adults Aged Seventy and Older Stethophone - Moderate or Severe Aortic Stenosis | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 1000 | 2026-12-01 | 2026-11-12 |
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices SESAME Procedure - Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction | Not applicable | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 200 | 2026-11-17 | 2026-11-12 |
| Human Experimental Models of Pain (HEMP) Placebo, Naproxen, Pregabalin - Acute Pain | Not applicable | Not yet recruiting | National Center for Complementary and Integrative Health (NCCIH) | 25 | 2026-11-17 | 2026-11-12 |
| Exercise and Diet Supplements for Older Patients Undergoing TAVI: the IRON-TAVI Trial Personalized Multidomain Exercise Program, Oral Protein and Iron Nutritional Supplementation, Usual Care - Aortic Stenosis Disease, Aortic Stenosis Symptomatic | Not applicable | Recruiting | University Hospital of Ferrara | 450 | 2026-11-04 | 2026-11-05 |
| Safety and Clinical Performance of the Next-Generation SAFESYNC Transcatheter Heart Valve in Patients With Severe Aortic Stenosis INOVARE® SAFESYNC Next-Generation Bioprosthetic Heart Valve - Aortic Stenosis Senile, Aortic Stenosis Symptomatic | Not applicable | Not yet recruiting | Braile Biomedica Ind. Com. e Repr. Ltda. | 40 | 2026-11-01 | 2026-09-08 |
| Efficacy and Safety of an LVEF-Guided Mavacamten Dose Up-Titration Strategy in Chinese Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy Mavacamten - Obstructive Hypertrophic Cardiomyopathy (oHCM) | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Nanchang University | 115 | 2026-11-01 | 2026-11-12 |
| Prospective Multicenter Study Evaluating Myval TAVR Safety and Effectiveness in High-risk Severe AR Myval THV series - Aortic Regurgitation, Aortic Disease | Not applicable | Not yet recruiting | Ceric Sàrl | 164 | 2026-10-30 | 2026-08-07 |
| Balloon- Versus Self-Expanding Intraannular TAVI in Small Aortic Annuli Meril Octapro+ THV System, Abbott Navitor/Navitor Vision THV system - Aortic Valve Stenosis | Not applicable | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 510 | 2026-10-26 | 2026-08-31 |
| SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY Trial Double-TAP post-dilatation - Aortic Valve Stenosis and/or Insufficiency, Hypoattenuated Leaflet Thickening | Not applicable | Recruiting | Erasmus Medical Center | 422 | 2026-10-26 | 2026-10-30 |
| Systematic Ambulatory ECG Monitoring Following TAVI Ambulatory ECG monitoring - Aortic Stenosis, Conduction Disturbances | Not applicable | Recruiting | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | 754 | 2026-10-23 | 2026-11-04 |
| Aom0304 in Adult Patients With Symptomatic Hypertrophic Cardiomyopathy QG101-23-0 enteric coated capsule (60/120/240/360 mg BID), QG101-23-0 enteric coated capsule (120/240/360/480mg BID) - Hypertrophic Cardiomyopathy (HCM), Obstructive HCM (oHCM) | Phase 2 | Not yet recruiting | Amckaus PTY LTD. | 56 | 2026-10-01 | 2026-06-30 |
Showing 20 of 1638. Sign in to see all of them.
Aortic Valve Stenosis (991) · Cardiomyopathy, Hypertrophic (353) · Aortic Valve Insufficiency (165) · Heart Valve Diseases (109) · Coronary Artery Disease (78) · Cardiovascular Diseases (65) · Bicuspid Aortic Valve Disease (62) · Heart Failure (62) · Mitral Valve Insufficiency (56) · Heart Diseases (48) · Cardiomyopathy, Dilated (39) · Aortic Valve, Calcification of (36) · Cardiomyopathies (33) · Hypertrophy, Left Ventricular (30)
Heart Diseases (1590) · Cardiovascular Diseases (1573) · Heart Valve Diseases (1529) · Ventricular Outflow Obstruction (1007) · Aortic Valve Stenosis (386) · Aortic Stenosis, Subvalvular (354) · Cardiomyopathies (326) · Pathological Conditions, Signs and Symptoms (254) · Vascular Diseases (221) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (195) · Pathologic Processes (167) · Congenital Abnormalities (133) · Genetic Diseases, Inborn (112) · Cardiovascular Abnormalities (111)
Transcatheter Aortic Valve Replacement (155) · MYK-461 (37) · Echocardiography (22) · Aspirin (14) · Exercise (13) · Clopidogrel (12) · Blood Specimen Collection (8) · Standard of Care (8) · Hematologic Tests (7) · Magnetic Resonance Imaging (7) · Magnetic Resonance Spectroscopy (7) · Saline Solution (7) · Anesthesia, Local (6) · Electrocardiography, Ambulatory (6) · Losartan (6)
Edwards Lifesciences (45) · National Heart, Lung, and Blood Institute (NHLBI) (38) · Abbott Medical Devices (31) · Bristol-Myers Squibb (25) · Medtronic Cardiovascular (18) · Xijing Hospital (18) · University Hospital, Montpellier (17) · Boston Scientific Corporation (16) · China National Center for Cardiovascular Diseases (16) · Institut für Pharmakologie und Präventive Medizin (16) · Assistance Publique - Hôpitaux de Paris (15) · Second Affiliated Hospital, Zhejiang University, School of Medicine (15) · Chinese Academy of Medical Sciences, Fuwai Hospital (14) · Oslo University Hospital (14) · The Cleveland Clinic (14)
United States (381) · Germany (233) · France (186) · United Kingdom (168) · Italy (164) · China (160) · Netherlands (133) · Canada (123) · Spain (104) · Denmark (87) · Switzerland (74) · Belgium (62) · Austria (51) · Poland (46) · Sweden (46)
Hendrik Treede, MD (7) · Martin B Leon, MD (6) · John Webb, MD (5) · Michael Reardon, MD (5) · Robert J Lederman, M.D. (5) · Barathi Sethuraman (4) · Manfred Boehm, M.D. (4) · Raj Makkar, MD (4) · Seung-jung Park, MD (4) · Vinod Thourani, MD (4) · Alibek Kh Mustafin, Professor (3)
PMID 20961243, PMID 33962483, PMID 21639811, PMID 29555836, PMID 31690104, PMID 31883339, PMID 35041482, PMID 38710669, PMID 42636950, PMID 12831818, PMID 24678937, PMID 27040324, PMID 31525069, PMID 32774184, PMID 34581194, PMID 35321859, PMID 35595203, PMID 35656983, PMID 36515976, PMID 16980116, PMID 20096533, PMID 20188503, PMID 20566953, PMID 21273254, PMID 22424519, PMID 22443479, PMID 23349346, PMID 24621999, PMID 24657695, PMID 25533774, PMID 25655063, PMID 25788234, PMID 26139739, PMID 26384204, PMID 26436963, PMID 26491110, PMID 26896466, PMID 27601429, PMID 27609682, PMID 27815101, PMID 28279376, PMID 28306757, PMID 28321003, PMID 28527771, PMID 28912187, PMID 29171730, PMID 29912142, PMID 29914867, PMID 30031719, PMID 30250733
2023 (9), 2019 (6), 2015 (2), 2025 (2), R01AG089981 (2), R21HL150373 (2), 1RC1LM010526 (1), 2009 (1), 2016 (1), 2017 (1), 2018 (1), 268201000048C-5-0-1 (1), K23HL004444 (1), K23HL078901 (1), K23HL136902 (1)