616 completed, 261 unknown, 244 recruiting, 69 terminated. 316 Not applicable, 174 Phase 2, 108 Phase 3, 101 Phase 1, 66 Phase 4.
Follow Cardiomyopathies: new trials by email Literature Review of Cardiomyopathies trials Research Report on Cardiomyopathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aficamten and Patient-Reported Outcomes in Real-World nHCM receiving aficamten - Hypertrophic Cardiomyopathy (HCM) | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2027-06-01 | 2026-09-29 | |
| Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy Melatonin 10 MG, Selenium, Placebo - Ppm, Cardiomyopathy | Not applicable | Not yet recruiting | Tanta University | 25 | 2026-12-20 | 2026-01-12 |
| PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study Clinical Decision Aid, Standard Care - Heart Failure, Coronary Artery Disease | Not yet recruiting | Medical College of Wisconsin | 60 | 2026-12-01 | 2025-10-14 | |
| Gradual Tapering or Discontinuation of Beta-Blockers After Stabilization With Mavacamten Therapy Beta-Blocker Sequential Tapering and Discontinuation, Beta-Blocker Baseline Stable-Dose Maintenance - Obstructive Hypertrophic Cardiomyopathy (oHCM) | Not applicable | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 286 | 2026-12-01 | 2026-09-11 |
| BAG3-DCM Natural History Study Dilated Cardiomyopathy (DCM), Cardiovascular Diseases | Not yet recruiting | Rocket Pharmaceuticals Inc. | 30 | 2026-12-01 | 2026-10-19 | |
| Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure Pulmonary Vein Isolation, Pharmacological Rate Control - Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | University of British Columbia | 1050 | 2026-11-01 | 2026-10-14 |
| To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE) Acoramidis (AG10) - Amyloidosis in Transthyretin (TTR), Amyloidosis, Familial | Phase 3 | Not yet recruiting | Eidos Therapeutics, a BridgeBio company | 250 | 2026-11-01 | 2026-08-11 |
| Cardiac Imaging in Systemic Disorders: the ORACLES Registry data collection - Lupus | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1500 | 2026-11-01 | 2026-02-13 | |
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices SESAME Procedure - Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction | Not applicable | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 200 | 2026-10-27 | 2026-10-22 |
| Human Experimental Models of Pain (HEMP) Placebo, Naproxen, Pregabalin - Acute Pain | Not applicable | Not yet recruiting | National Center for Complementary and Integrative Health (NCCIH) | 25 | 2026-10-27 | 2026-10-22 |
| A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy Adults ATI-105, Placebo - Friedreich Ataxia, Cardiomyopathies | Phase 1 | Not yet recruiting | Adjuvia Therapeutics, Inc. | 60 | 2026-10-26 | 2026-10-09 |
| Aom0304 in Adult Patients With Symptomatic Hypertrophic Cardiomyopathy QG101-23-0 enteric coated capsule (60/120/240/360 mg BID), QG101-23-0 enteric coated capsule (120/240/360/480mg BID) - Hypertrophic Cardiomyopathy (HCM), Obstructive HCM (oHCM) | Phase 2 | Not yet recruiting | Amckaus PTY LTD. | 56 | 2026-10-01 | 2026-06-30 |
| Echocardiographic Perspectives on Transient Mitral Regurgitation After Septal Myectomy Hypertrophic Cardiomyopathy | Not yet recruiting | University Health Network, Toronto | 150 | 2026-10-01 | 2026-10-14 | |
| Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy Coronary sinus reducer, Placebo procedure - Hypertrophic Cardiomyopathy | Not applicable | Not yet recruiting | Imperial College London | 50 | 2026-10-01 | 2026-10-08 |
| Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP) - Bradycardia, Atrioventricular Block | Not applicable | Not yet recruiting | Yonsei University | 300 | 2026-10-01 | 2026-09-04 |
| Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications Type 2 Diabetes Mellitus, Cardiovascular Diseases | Not yet recruiting | Assiut University | 85 | 2026-10-01 | 2026-09-29 | |
| An AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM) AFTX-201 - Dilated Cardiomyopathy (DCM), BAG3 Mutation Associated Dilated Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Affinia Therapeutics | 22 | 2026-10-01 | 2026-10-21 |
| Nutritional Assessment in Children With Cardiomyopathy Cardiomyopathies, Malnutrition | Not yet recruiting | Assiut University | 108 | 2026-09-30 | 2026-10-05 | |
| Evaluation of Mavacamten-Based Practice in Chinese Adults With Obstructive Hypertrophic Cardiomyopathy Mavacamten - Obstructive Hypertrophic Cardiomyopathy (oHCM) | Not yet recruiting | Bristol-Myers Squibb | 800 | 2026-09-30 | 2026-09-29 | |
| Spectroscopic Assessment of Myocardial Oxygenation Changes in Pediatric Heart Surgery Myocardial Ischemia, Heart Defects, Congenital | Recruiting | Spectrocor | 30 | 2026-09-17 | 2026-09-28 |
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Cardiomyopathy, Hypertrophic (352) · Heart Failure (296) · Cardiomyopathy, Dilated (242) · Myocarditis (152) · Heart Diseases (77) · Cardiovascular Diseases (76) · Takotsubo Cardiomyopathy (63) · Arrhythmias, Cardiac (61) · Myocardial Reperfusion Injury (56) · Death, Sudden, Cardiac (52) · Myocardial Infarction (51) · Arrhythmogenic Right Ventricular Dysplasia (47) · Coronary Artery Disease (43) · Amyloidosis (37)
Cardiovascular Diseases (1300) · Heart Diseases (1299) · Pathological Conditions, Signs and Symptoms (440) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (406) · Pathologic Processes (364) · Heart Valve Diseases (363) · Aortic Valve Disease (357) · Aortic Stenosis, Subvalvular (353) · Aortic Valve Stenosis (348) · Genetic Diseases, Inborn (344) · Cardiomegaly (263) · Vascular Diseases (245) · Laminopathies (238) · Nutritional and Metabolic Diseases (147)
MYK-461 (37) · Echocardiography (25) · Blood Specimen Collection (14) · Exercise (13) · Electrocardiography (12) · Metoprolol (12) · Natriuretic Peptide, Brain (10) · Standard of Care (9) · Cardiac Resynchronization Therapy (8) · Carvedilol (8) · Magnetic Resonance Spectroscopy (8) · Perhexiline (8) · empagliflozin (8) · Bisoprolol (7) · Defibrillators, Implantable (7)
National Heart, Lung, and Blood Institute (NHLBI) (37) · Bristol-Myers Squibb (28) · Mayo Clinic (27) · Assistance Publique - Hôpitaux de Paris (22) · Xijing Hospital (16) · Imperial College London (14) · Assiut University (13) · China National Center for Cardiovascular Diseases (12) · Chinese Academy of Medical Sciences, Fuwai Hospital (11) · Second Affiliated Hospital, Zhejiang University, School of Medicine (11) · Emory University (10) · Abbott Medical Devices (9) · Alnylam Pharmaceuticals (9) · Duke University (9) · Pfizer (9)
United States (447) · United Kingdom (142) · France (134) · China (123) · Germany (123) · Italy (108) · Canada (88) · Spain (70) · Netherlands (58) · Denmark (44) · Poland (44) · Brazil (41) · Sweden (39) · Belgium (35) · Austria (32)
Paolo Della Bella, MD (5) · Barry Greenberg, MD (4) · Michael Zapien, MS, CCRA (4) · Yang Yan (4) · Dao Wen Wang, Doctor (3) · Dhanunjaya Lakkireddy, MD (3) · James Ware (3) · Jared Gollob, MD (3) · Sarah Thordsen, MD (3)
PMID 37979797, PMID 42636950, PMID 36718638, PMID 38979608, PMID 40739200, PMID 10400005, PMID 16928995, PMID 17582361, PMID 21087331, PMID 21505058, PMID 22651868, PMID 22936827, PMID 23362308, PMID 24414062, PMID 24621999, PMID 24750460, PMID 25142002, PMID 25176015, PMID 25533774, PMID 26680013, PMID 28306757, PMID 28912187, PMID 28917683, PMID 29447739, PMID 30077990, PMID 30360992, PMID 31642911, PMID 32871100, PMID 33574022, PMID 34081217, PMID 34525837, PMID 35861811, PMID 36404406, PMID 36456068, PMID 36652223, PMID 37010012, PMID 37480391, PMID 38722325, PMID 39213194, PMID 39217450, PMID 39302117, PMID 39855458, PMID 41903627, PMID 42307907, PMID 42389794, PMID 42624353, PMID 42669063, PMID 42669065, PMID 7994859, PMID 10368877
2019 (12), 2023 (6), 2015 (5), 2025 (5), 2004 (2), 2009 (2), 2016 (2), 2017 (2), 2018 (2), U01HL088942 (2), 1RC1LM010526 (1), 2014 (1), 3UM1AI068614-14S1 (1), 5UM1HL087318 (1), K12AR084222 (1)