11 completed, 7 unknown, 2 terminated, 2 withdrawn. 24 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 24 | Completed 11, Unknown 7, Terminated 2, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1 |
Follow Heart Block: new trials by email Literature Review of Heart Block trials Research Report on Heart Block
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EArly Effect of Glucocorticoid on Incidence of Persistent Left BundlE Branch Block (LBBB) Post-TAVR (EAGLE-TAVR Trial) Methylprednisolone (Corticosteroid), Placebo - Transcatheter Aortic Valve Replacemen, Left Bundle Branch Block | Phase 4 | Not yet recruiting | Xiao-dong Zhuang | 200 | 2025-01-01 | 2025-01-07 |
| Micra AV Tracking During Exercise Testing Medtronic Micra AV Device - Heart Block AV | Phase 4 | Withdrawn | Duke University | 2024-05-01 | 2024-04-17 | |
| Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation Ampicillin sulbactam 3 days, Placebo 3 days - Heart Block, CIED Related Infection | Phase 4 | Completed | Universitas Diponegoro | 60 | 2024-04-01 | 2025-02-27 |
| Glucocorticoid Treatment in Transaortic Valve Replacement to Reduce the Incidence of Conduction Disturbances (GLUCO-TAVR). Methylprednisolone, Placebo - Heart Block, Aortic Stenosis | Phase 4 | Unknown | Hospital General Universitario de Alicante | 100 | 2023-08-12 | 2023-10-11 |
| The Leadless AV Versus DDD Pacing Study Conventional pacemaker DDD, Leadless pacemaker Micra AV - Cardiac Pacemaker, Arrhythmias, Cardiac | Phase 4 | Active not recruiting | Insel Gruppe AG, University Hospital Bern | 100 | 2022-08-23 | 2026-04-29 |
| The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker AAI 40 bpm, AAI 60 bpm, AAI 90 bpm - Aortic Blood Pressure | Phase 4 | Completed | Tartu University Hospital | 27 | 2015-06-01 | 2018-07-10 |
| Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients beta blockers, RAAS blockers - Heart Failure (HF) | Phase 4 | Completed | Hasselt University | 80 | 2014-07-01 | 2019-08-01 |
| Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Left ventricular pacing through coronary sinus tributaries (Attain StarFix), Right ventricular pacing (Medtronic) - Bradyarrhythmias, Arrhythmias | Phase 4 | Unknown | University of Sao Paulo | 12 | 2012-06-01 | 2012-11-06 |
| Syncope: Pacing or Recording in the Later Years pacemaker, implantable loop recorder - Syncope, Heart Block | Phase 4 | Completed | Canadian Institutes of Health Research (CIHR) | 120 | 2011-08-01 | 2019-05-16 |
| Resynchronization in Paced Heart Failure Patients With Implantable Cardioverter Defibrillator (ICD) Indication second LV lead in CRT - Heart Failure, Left Bundle-Branch Block | Phase 4 | Unknown | Schuechtermann-Klinik | 30 | 2011-05-01 | 2011-08-11 |
| Biventricular Alternative Pacing Biventricular Pacing (DDD(R)- BiV) - Atrioventricular Block | Phase 4 | Withdrawn | Medtronic Cardiac Rhythm and Heart Failure | 2007-11-01 | 2026-11-04 | |
| Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Septal pacing, His lead activated - Atrioventricular Block | Phase 4 | Completed | Aarhus University Hospital Skejby | 40 | 2007-09-01 | 2012-05-15 |
| Virtual Clinic Pacemaker Follow-up Home Monitoring of pacemaker, Home Monitoring of pacemaker deactivated - Sick Sinus Syndrome, Heart Block | Phase 4 | Terminated | Biotronik SE & Co. KG | 123 | 2007-05-01 | 2014-10-31 |
| Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response Closed Loop Stimulation (CLS), Standard Rate Adaptive (R) Technology, Non-rate adaptive (DDD) pacing - Bradycardia | Phase 4 | Completed | Biotronik, Inc. | 1491 | 2006-05-01 | 2012-12-20 |
| Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Vitatron T70 DR - Sick Sinus Syndrome | Phase 4 | Unknown | Medtronic BRC | 402 | 2004-11-01 | 2011-08-02 |
| Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease PACEMAKER SYMPHONY 2550 - Sinus Node Dysfunction, Brady Tachy Syndrome | Phase 4 | Completed | LivaNova | 400 | 2004-07-01 | 2010-07-27 |
| Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Vitatron C50 D Model C50A2 of Vitatron C60 DR model C60A2, Required pacemaker setting - Bradycardia; Sick Sinus Syndrome, AV Block | Phase 4 | Unknown | Medtronic BRC | 150 | 2004-04-01 | 2011-08-02 |
| EnTRINSIC - EnPulse Trial on Search AV+ Influence Search AV+ algorithm - Arrhythmia, Sinus | Phase 4 | Terminated | Medtronic Cardiac Rhythm and Heart Failure | 135 | 2004-02-01 | 2025-07-03 |
| Effect of Cardiac Resynchronization Therapy (CRT) on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response CRT - Skeletal Muscle Changes After Crt | Phase 4 | Completed | Helse Stavanger HF | 21 | 2004-01-01 | 2015-07-28 |
| Spontaneous Atrio Ventricular Conduction Preservation Symphony D 2450, Symphony DR 2550 - Sinus Node Dysfunction, Bradycardia-Tachycardia Syndrome | Phase 4 | Completed | LivaNova | 622 | 2003-11-01 | 2008-04-09 |
Showing 20 of 24. Sign in to see all of them.
Sick Sinus Syndrome (11) · Atrioventricular Block (7) · Bradycardia (6) · Bundle-Branch Block (5) · Heart Failure (5) · Atrial Fibrillation (4) · Arrhythmias, Cardiac (3) · Cardiovascular Diseases (2) · Aortic Valve Stenosis (1) · Arrhythmia, Sinus (1) · Heart Diseases (1) · Inflammation (1) · Syncope (1) · Ventricular Dysfunction (1)
Cardiac Conduction System Disease (24) · Pathologic Processes (24) · Pathological Conditions, Signs and Symptoms (24) · Heart Diseases (23) · Cardiovascular Diseases (22) · Arrhythmias, Cardiac (21) · Arrhythmia, Sinus (10) · Aortic Valve Disease (1) · Consciousness Disorders (1) · Heart Valve Diseases (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurologic Manifestations (1) · Signs and Symptoms (1)
Methylprednisolone (2) · Adrenal Cortex Hormones (1) · Adrenergic beta-Antagonists (1) · Atenolol (1) · Cardiac Resynchronization Therapy (1) · Ivabradine (1) · Nebivolol (1) · Saline Solution (1) · sultamicillin (1)
Medtronic BRC (4) · LivaNova (2) · Medtronic Cardiac Rhythm and Heart Failure (2) · Aarhus University Hospital Skejby (1) · Biotronik SE & Co. KG (1) · Biotronik, Inc. (1) · Canadian Institutes of Health Research (CIHR) (1) · Duke University (1) · Guidant Corporation (1) · Hasselt University (1) · Helse Stavanger HF (1) · Hospital General Universitario de Alicante (1) · Insel Gruppe AG, University Hospital Bern (1) · Schuechtermann-Klinik (1) · Tartu University Hospital (1)
Germany (8) · United Kingdom (5) · United States (4) · Belgium (3) · France (3) · Italy (3) · Austria (2) · Denmark (2) · Spain (2) · Switzerland (2) · Brazil (1) · Canada (1) · China (1) · Czechia (1) · Finland (1)
C Nimeth, MD (1) · Camille Frazier-Mills (1) · Chris van Groeningen, MD (1) · David Fluck, Dr. (1) · Emmanuel Simantirakis, MD (1) · Freddy Abi-Samra, MD (1) · Jens C Nielsen, Phycisian (1) · Jochem F. Stockinger, MD (1) · Ludwig Binner, MD (1) · Mads B Kronborg, Phycisian (1) · Michael Jakob, MD (1) · Panagiotis Vardas, MD, Cardiology Professor (1) · Patrick Attuel, MD (1)
PMID 23322010, PMID 23419655, PMID 24509688, PMID 29581554, PMID 31389718, PMID 32216911, PMID 32395337, PMID 35210082