386 completed, 117 unknown, 101 terminated, 82 recruiting. 290 Phase 2, 203 Phase 3, 158 Phase 4, 94 Phase 1, 92 Not applicable.
Follow this drug Literature Review of Methylprednisolone trials Research Report on Methylprednisolone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Use of High Dose Testosterone Followed by Darolutamide Compared to the Usual Care for Patients With Metastatic Prostate Cancer Abiraterone Acetate, Biospecimen Collection, Bone Scan - Metastatic Castration-Resistant Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 / Phase 3 | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 432 | 2027-01-06 | 2026-10-01 |
| Combination Therapy With Danazol, Prednisolone, and Thalidomide for Thalidomide-Refractory Transfusion-Dependent β-Thalassemia Thalidomide, Danazol, Prednisolone - Beta-Thalassemia, Thalassemia | Phase 3 | Recruiting | Khyber Medical University Peshawar | 172 | 2026-10-12 | 2026-10-21 |
| taVNS in Veterans With Knee OA (AVAHCS) Methylprednisolone acetate, taVNS - Knee Osteoarthritis | Not applicable | Recruiting | VA Office of Research and Development | 40 | 2026-09-29 | 2026-10-05 |
| Intrathecal Cytarabine and Hydrocortisone for the Early Treatment of ICANS in Patients Undergoing CAR T Therapy for Non Hodgkin Lymphoma Therapeutic Hydrocortisone, Cytarabine, Dexamethasone - Non-hodgkin Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma | Phase 2 | Recruiting | Vanderbilt-Ingram Cancer Center | 59 | 2026-09-25 | 2026-10-02 |
| Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery. PAI, PAI + steroid, PAI + zilretta - Knee Osteoarthritis, Musculoskeletal Disease | Phase 2 / Phase 3 | Recruiting | Walter Reed National Military Medical Center | 240 | 2026-09-01 | 2026-08-19 |
| Study of Atorvastatin and Its Effects in Clinical and Radiological Aspects in Patients With Moderate-to-Severe Thyroid Eye Disease Atorvastatin, methylprednisolone (IVMP) - Thyroid Eye Disease, Graves Ophthalmopathy | Phase 1 | Not yet recruiting | Banu Aji Dibyasakti | 64 | 2026-08-30 | 2026-08-13 |
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone - Asthma (Diagnosis) | Phase 2 | Recruiting | Johns Hopkins All Children's Hospital | 159 | 2026-08-01 | 2026-08-12 |
| Teprotumumab N01 Versus Methylprednisolone After Urgent Orbital Decompression for Dysthyroid Optic Neuropathy Teprotumumab N01, Intravenous Methylprednisolone (IVMP) - Thyroid Eye Disease, TED, Graves Ophthalmopathy | Phase 2 | Not yet recruiting | Sun Yat-sen University | 60 | 2026-08-01 | 2026-05-19 |
| A Study of Teprotumumab N01 in Subjects With Active Thyroid Eye Disease Teprotumumab N01, Methylprednisolone - Thyroid Eye Disease | Phase 4 | Recruiting | Innovent Biologics (Suzhou) Co. Ltd. | 92 | 2026-07-30 | 2026-08-13 |
| Multi-target Drugs Sequential Combination Therapy in Adults Patients With Newly Diagnosed Primary Immune Thrombocytopenia standard-dose methylprednisolone/prednisone., thrombopoietin receptor agonist(TPO-RA), including but not limited to hetrombopag or eltrombopag., rituximab. - ITP - Immune Thrombocytopenia | Phase 4 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 38 | 2026-06-22 | 2026-08-26 |
| Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation Research Privosegtor, Methylprednisolone, Placebo - Optic Neuritis | Phase 3 | Recruiting | Oculis | 210 | 2026-05-28 | 2026-08-14 |
| Greater Occipital Nerve Block for Migraine With Medication Overuse Headache Lidocaine 2% and Methylprednisolone 80 mg, Placebo - Migraine Disorders, Medication Overuse Headache | Not applicable | Recruiting | Mahidol University | 130 | 2026-05-12 | 2026-10-08 |
| Prospective Randomized Controlled Study: Amimaitosai Injection Combined With Corticosteroids for Gastrointestinal aGVHD Amimaitosai injection, Methylprednisolone - Acute Gastrointestinal Graft-versus-host Disease | Early Phase 1 | Enrolling by invitation | Chinese PLA General Hospital | 60 | 2026-05-01 | 2026-09-04 |
| Prehospital Pulse-dose Glucocorticoid in Patients With ST-segment Elevation Myocardial Infarction 2 - The PULSE-MI 2 Trial Methylprednisolone 250 mg, NaCl (0,9%) - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Recruiting | Thomas Engstrom | 5204 | 2026-04-20 | 2026-04-23 |
| Corticosteroids in Hyperinflammatory Phenotype of Critical Illness Methylprednisolone (MP), Placebo - Sepsis, Acute Respiratory Distress Syndrome | Phase 2 | Recruiting | Bin Du | 150 | 2026-04-15 | 2026-05-26 |
| Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases: Methylprednisolone (Corticosteroid), Dexamethasone - Brain Metastases From Solid Tumors | Phase 2 / Phase 3 | Not yet recruiting | The Second Affiliated Hospital of Hainan Medical University | 400 | 2026-04-15 | 2026-04-21 |
| Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH) Mitoxantrone liposome, Etoposide, Pegaspargase (PEG) Asparaginase - Extranodal NK T Cell Lymphoma, Hemophagocytic Lymphohistiocytosis (HLH) | Phase 1 / Phase 2 | Recruiting | Beijing Tongren Hospital | 25 | 2026-04-01 | 2026-04-13 |
| Nutritional + Usual Corticosteroids Randomized Trial for Immune-Related pneumoniA - Therapeutic Utilization Evaluation Spirulina-Bifidobacterium capsule, Fish oil-grape seed-blueberry soft capsule, Ganoderma spore oil - Immune Checkpoint Inhibitor-Related Pneumonitis, Drug-Related Side Effects and Adverse Reactions | Not applicable | Not yet recruiting | Guangzhou Institute of Respiratory Disease | 60 | 2026-04-01 | 2026-05-26 |
| Methylprednisolone for Moderate to Severe Traumatic Brain Injury Placebo, Methylprednisolone (MP) - Traumatic Brain Injury | Phase 4 | Recruiting | Zhangjiagang First People's Hospital | 520 | 2026-03-29 | 2026-09-22 |
Showing 20 of 786. Sign in to see all of them.
Leukemia (59) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (54) · Lymphoma (49) · Burkitt Lymphoma (39) · Lymphoma, Large B-Cell, Diffuse (38) · Lymphoma, Follicular (37) · Myelodysplastic Syndromes (37) · Graft vs Host Disease (36) · Lymphoma, Non-Hodgkin (35) · Multiple Myeloma (32) · Leukemia, Myeloid, Acute (31) · Leukemia, Myeloid, Chronic-Phase (30) · Leukemia, Myeloid, Accelerated Phase (28) · Leukemia, Lymphocytic, Chronic, B-Cell (27) · Lymphoma, Large-Cell, Immunoblastic (27)
National Institute of Allergy and Infectious Diseases (NIAID) (19) · Hoffmann-La Roche (17) · M.D. Anderson Cancer Center (16) · Children's Oncology Group (13) · Northwestern University (13) · Masonic Cancer Center, University of Minnesota (11) · National Cancer Institute (NCI) (11) · Astellas Pharma Inc (9) · Copenhagen University Hospital, Rigshospitalet (9) · Mayo Clinic (8) · Sanofi (8) · Case Comprehensive Cancer Center (7) · Genentech, Inc. (7) · Incyte Corporation (7) · Stanford University (7)
United States (354) · China (94) · Canada (61) · France (56) · Italy (53) · Spain (49) · United Kingdom (49) · Denmark (43) · Germany (40) · Australia (36) · Belgium (36) · Brazil (28) · Turkey (Türkiye) (27) · Poland (26) · Sweden (24)
Richard Burt, MD (9) · Viktoria Lindberg-Larsen, MD (6) · Rodica Morariu-Zamfir, MD (4) · Barbara Jean Bambach, MD (3) · James R Berenson, MD (3) · Kenneth G. Lucas, MD (3) · Kenneth Newell, MD, PhD (3) · Kern Singh, MD (3)
PMID 33693991, PMID 37678236, PMID 41671463, PMID 16008588, PMID 24026316, PMID 27307294, PMID 28763548, PMID 30234517, PMID 30536810, PMID 32470437, PMID 34048072, PMID 34677593, PMID 34778952, PMID 35244208, PMID 35689489, PMID 37022569, PMID 37505794, PMID 37624739, PMID 38864363, PMID 40351190, PMID 42208560, PMID 10093981, PMID 10676716, PMID 11113831, PMID 11824975, PMID 11825832, PMID 11877568, PMID 12131699, PMID 12660340, PMID 14694168, PMID 15049798, PMID 15803929, PMID 15888041, PMID 16368644, PMID 16382014, PMID 16556894, PMID 16687625, PMID 16796717, PMID 16888080, PMID 17185058, PMID 17398307, PMID 17426195, PMID 17487675, PMID 1750226, PMID 17645714, PMID 17660026, PMID 17889125, PMID 17910637, PMID 18035553, PMID 18050189
U10CA180886 (13), 2023 (11), 2015 (10), 2017 (6), P30CA016672 (5), U10CA098543 (5), 2008 (4), 2009 (4), 2019 (4), 2025 (4), P30CA006516 (4), 2014 (3), 2018 (3), P30CA043703 (3), 2016 (2)