72 completed, 35 recruiting, 32 unknown, 13 not yet recruiting. 70 Not applicable, 4 Phase 4, 2 Phase 3, 1 Phase 2.
Follow Transcatheter Aortic Valve Replacement: new trials by email Literature Review of Transcatheter Aortic Valve Replacement trials Research Report on Transcatheter Aortic Valve Replacement
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multi-center Research Clinical Trial Protocol for Etiology-pathology and Repair Classification of Mitral and Tricuspid Valves Valve repair, Valve replacement - Heart Valvular Disease | Not applicable | Not yet recruiting | Keli Huang | 200 | 2026-11-01 | 2026-10-07 |
| Balloon- Versus Self-Expanding Intraannular TAVI in Small Aortic Annuli Meril Octapro+ THV System, Abbott Navitor/Navitor Vision THV system - Aortic Valve Stenosis | Not applicable | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 510 | 2026-10-26 | 2026-08-31 |
| Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) Transcatheter Aortic Valve Replacement (TAVR) with surgical oversight, Transcatheter Aortic Valve Replacement (TAVR) without surgical oversight - Aortic Stenosis, Severe Aortic Stenosis | Phase 4 | Not yet recruiting | University of Alberta | 600 | 2026-08-01 | 2026-06-02 |
| Selection of Transcatheter Heart vaLve With Intermediate Sizing in Patients With Severe Aortic Stenosis Treated With Transcatheter Aortic Valve Replacement Transcatheter Heart Valve - Aortic Stenosis, Severe | Phase 4 | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 604 | 2026-08-01 | 2026-07-08 |
| TAVR vs SAVR in Severe Bicuspid Aortic Stenosis Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve - Bicuspid Aortic Valve Disease | Not applicable | Recruiting | Cedars-Sinai Medical Center | 1200 | 2026-07-23 | 2026-08-14 |
| TRanscatheter Aortic-Valve Implantation Without On-site Cardiac Surgery Transcatheter Aortic Valve Implantation - Aortic Stenosis | Not applicable | Recruiting | University Hospital of Ferrara | 1612 | 2026-05-25 | 2026-08-21 |
| Comparison of Myval THV Series With Guideline-Directed Medical Therapy in Participants With Moderate Aortic Stenosis Transcatheter aortic valve Implantation - Moderate Aortic Stenosis | Not applicable | Not yet recruiting | Meril Life Sciences Pvt. Ltd. | 778 | 2026-05-17 | 2026-05-06 |
| Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty - Aortic Stenosis, Aortic Regurgitation | Not yet recruiting | Beijing Anzhen Hospital | 5500 | 2026-05-10 | 2026-05-26 | |
| A Prospective, Multicenter, Observational Study Evaluating Safety and Effectiveness of SAPIEN 3 Transcatheter Aortic Valve Replacement for Type-0 Bicuspid Aortic Valve Stenosis Patients in China Transcatheter Aortic Valve Replacement - Aortic Stenosis, AORTIC VALVE DISEASES | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 170 | 2026-04-15 | 2026-05-07 | |
| Association Between Changes in Aortic Valve Area and Pulmonary Congestion After Transcatheter Aortic Valve Implantation Transcatheter Aortic Valve Implantation (TAVI) - Aortic Stenosis | Recruiting | Istanbul University - Cerrahpasa | 52 | 2026-03-31 | 2026-08-31 | |
| PRessure-based Evaluation of Disease Improvement in the Course of TAVI Transcatheter aortic valve replacement (TAVR / TAVI) - Aortic Stenosis | Not yet recruiting | Istanbul Mehmet Akif Ersoy Educational and Training Hospital | 100 | 2026-03-30 | 2026-04-03 | |
| Cardiac Amyloidosis in Patients With Aortic Stenosis transcatheter aortic valve replacement (TAVR) - Aortic Stenosis, Transthyretin Amyloid Cardiomyopathy | Not yet recruiting | Shanghai Zhongshan Hospital | 143 | 2026-01-31 | 2026-01-20 | |
| A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis Transcatheter Aortic Valve Implantation, Optimal medication treatment - Severe Aortic Valve Stenosis | Not applicable | Recruiting | RenJi Hospital | 25 | 2025-12-19 | 2026-01-13 |
| Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR F2 Filter and Delivery System, Transcatheter Aortic Valve Replacement (TAVR) - Aortic Stenosis Treated With TAVI, Aortic Diseases | Not applicable | Recruiting | EnCompass Technologies, Inc. | 500 | 2025-09-09 | 2025-11-20 |
| Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure) Aortic valve replacement - Aortic Valve Disease, Surgery--Complications | Not yet recruiting | Barts & The London NHS Trust | 150 | 2025-09-01 | 2024-11-18 | |
| Transfemoral TAVI With or Without Coronary Angiogram in Patients With Severe Aortic Stenosis (PURE TAVI) Transcatheter aortic valve implantation - Severe Aortic Stenosis | Not applicable | Enrolling by invitation | Rede Optimus Hospitalar SA | 620 | 2025-08-08 | 2026-08-25 |
| Prospective, Multicenter, Randomized Controlled Clinical Study Evaluating the VitaFlow Liberty® Flex Transcatheter Aortic Valve Delivery System for the Treatment of Severe Aortic Stenosis Lesions Transcatheter Aortic Valve Replacement - Aortic Valve Stenosis | Not applicable | Recruiting | Shanghai Zhongshan Hospital | 232 | 2025-07-30 | 2025-08-28 |
| ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™ Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Recruiting | JenaValve Technology, Inc. | 1016 | 2025-06-18 | 2026-09-17 |
| Isolated Surgical Aortic Valve Replacement in Low Risk AS Patients surgical aortic valve replacement, Transcatheter aortic valve replacement - Aortic Stenosis | Not applicable | Recruiting | Osaka University | 450 | 2025-06-01 | 2026-09-04 |
| ACURATE Enhance Post Market Study Transcatheter Aortic Valve Implantation/Replacement - Aortic Valve Stenosis, Aortic Valve Calcification | Withdrawn | Boston Scientific Corporation | 2025-05-01 | 2025-06-24 |
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Aortic Valve Stenosis (129) · Aortic Valve Disease (27) · Aortic Valve Insufficiency (18) · Heart Valve Diseases (15) · Bicuspid Aortic Valve Disease (10) · Cardiovascular Diseases (6) · Aortic Diseases (4) · Aortic Valve, Calcification of (4) · Bundle-Branch Block (4) · Coronary Artery Disease (4) · Heart Diseases (4) · Heart Failure (3) · Stroke (3) · Aneurysm, Ascending Aorta (2) · Atrioventricular Block (2)
Edwards Lifesciences (9) · Abbott Medical Devices (8) · Xijing Hospital (5) · Assiut University (4) · Boston Scientific Corporation (3) · Cedars-Sinai Medical Center (3) · JenaValve Technology, Inc. (3) · Medical University of Vienna (3) · NVT GmbH (3) · Seung-Jung Park (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · China National Center for Cardiovascular Diseases (2) · Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Copenhagen University Hospital, Rigshospitalet (2) · Deutsches Herzzentrum Muenchen (2)
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Ling Tao, M.D, Ph.D (3) · Raj Makkar, MD (3) · Rutao Wang, M.D, Ph.D (3) · Barathi Sethuraman (2) · Ganesh Manoharan, MD (2) · Gerald Yong, MD (2) · Gert Richardt, MD (2) · Hans GH Thyregod, MD, PhD (2) · Hendrik Treede, MD (2) · Mohamed Abdel-Wahab, MD (2) · Seung-jung Park, MD (2) · Seung-jung Park, MD, PhD (2) · Susheel Kodali, MD (2) · Tobias Geisler, Prof. (2) · Vinod Thourani, MD (2)
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