Unconsciousness: Clinical Trials

309 completed, 100 unknown, 70 recruiting, 31 terminated. 239 Not applicable, 39 Phase 2, 27 Phase 3, 21 Phase 4, 15 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	239	Completed 133, Unknown 38, Recruiting 32, Not yet recruiting 14, Terminated 11, Enrolling by invitation 4, Withdrawn 4, Active not recruiting 3
Phase 2	39	Completed 20, Terminated 6, Recruiting 3, Unknown 3, Withdrawn 3, Not yet recruiting 2, Active not recruiting 1, Suspended 1
Phase 3	27	Completed 15, Terminated 4, Unknown 4, Recruiting 2, Withdrawn 2
Phase 4	21	Completed 13, Unknown 4, Terminated 2, Recruiting 1, Withdrawn 1
Phase 1	15	Completed 9, Suspended 2, Unknown 2, Active not recruiting 1, Withdrawn 1
Early Phase 1	3	Completed 2, Withdrawn 1

Follow Unconsciousness: new trials by email Literature Review of Unconsciousness trials Research Report on Unconsciousness

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury	Phase 2	Not yet recruiting	University of California, Los Angeles	264	2028-01-10	2026-01-16
AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy - Disorders of Consciousness, Vegetative State	Not applicable	Not yet recruiting	Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.	200	2026-12-01	2026-10-02
Miniature In-line Respirator Hope inVent - Brain Death, Respiration, Artificial	Not applicable	Not yet recruiting	National Institutes of Health Clinical Center (CC)	5	2026-10-27	2026-10-22
Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall Whole-body point-of-care ultrasound (POCUS) - Accidental Falls, Aged		Recruiting	Kocaeli City Hospital	105	2026-10-12	2026-10-21
Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in Japan Application of ambulatory cardiac monitor - Atrial Fibrillation (AF), Atrial Flutter	Not applicable	Not yet recruiting	iRhythm Technologies, Inc.	130	2026-09-30	2026-10-19
Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP) Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO. - Death, Brain	Not applicable	Not yet recruiting	Centre Hospitalier Régional d'Orléans	28	2026-09-15	2026-07-10
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP) Consciousness Disorders, Persistent Vegetative State		Not yet recruiting	Nicosia General Hospital	40	2026-09-15	2026-07-30
Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study Value of neurofilament light chain (NFL) at different time points - Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission		Not yet recruiting	Assistance Publique - Hôpitaux de Paris	270	2026-09-01	2026-08-12
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence Terminal Illness, End-of-Life Care		Not yet recruiting	Noah Tech, Corp.	20	2026-09-01	2026-03-17
Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State	Not applicable	Not yet recruiting	Centre Hospitalier Universitaire de Liege	4	2026-09-01	2026-10-19
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting - Cardiovascular Diseases, Cardiovascular Diseases Risk		Enrolling by invitation	Peerbridge Health, Inc	1000	2026-08-20	2026-08-21
Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE) Wearable holter monitor - Orthostatic Hypotension, Reflex Syncope		Recruiting	Boston Scientific Corporation	40	2026-08-06	2026-10-14
NEURO - Prognostication Using Late Somatosensory Evoked - Potentials EEGs - Comatose, Prognosis	Not applicable	Not yet recruiting	University Hospital, Bordeaux	50	2026-06-30	2026-04-02
Vagus Nerve Stimulation in Patients in Comatose State Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS) - Traumatic Brain Injury, Severe Traumatic Brain Injury	Not applicable	Recruiting	Sima Mofakham	10	2026-06-26	2026-07-22
The Effect of Auditory Stimulation and the "Love Glove" Technique Voice of a patient's relative, Voice of nurse, Love glove - Unconscious State	Not applicable	Not yet recruiting	Manisa Celal Bayar University	100	2026-06-01	2026-05-22
Promoting Recovery After Brain Injury Using Focused Ultrasound Low-intensity focused ultrasound - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury	Not applicable	Recruiting	Massachusetts General Hospital	36	2026-05-26	2026-06-15
fNIRS for Disorders of Consciousness Functional Near-Infrared Spectroscopy Monitoring - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness		Recruiting	University of California, Los Angeles	55	2026-05-01	2026-06-08
The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury Coma Family Program 1, Coma Family Program 2 - Caregiver Distress, Emotional Distress	Not applicable	Not yet recruiting	Massachusetts General Hospital	150	2026-05-01	2026-02-20
Auditory Processing in DOC Patients Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG) - Disorder of Consciousness, Unresponsive Wakefulness Syndrome		Not yet recruiting	BDH-Klinik Hessisch Oldendorf	42	2026-04-15	2026-03-06
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury SeeMe Multimodal Auditory Command Protocol - Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury	Not applicable	Recruiting	Stony Brook University	80	2026-03-30	2026-05-05

Showing 20 of 570. Sign in to see all of them.

Narrower conditions

Syncope (196)  ·  Coma (134)  ·  Syncope, Vasovagal (88)  ·  Persistent Vegetative State (87)  ·  Consciousness Disorders (75)  ·  Brain Death (71)  ·  Brain Injuries, Traumatic (43)  ·  Brain Injuries (39)  ·  Heart Arrest (34)  ·  Arrhythmias, Cardiac (33)  ·  Atrial Fibrillation (24)  ·  Bradycardia (22)  ·  Stroke (19)  ·  Emergencies (17)

Broader conditions

Neurobehavioral Manifestations (570)  ·  Nervous System Diseases (568)  ·  Pathological Conditions, Signs and Symptoms (568)  ·  Neurologic Manifestations (567)  ·  Signs and Symptoms (504)  ·  Consciousness Disorders (495)  ·  Central Nervous System Diseases (230)  ·  Brain Diseases (228)  ·  Pathologic Processes (207)  ·  Cardiovascular Diseases (167)  ·  Heart Diseases (114)  ·  Primary Dysautonomias (102)  ·  Autonomic Nervous System Diseases (99)  ·  Mental Disorders (95)

Interventions

Transcranial Direct Current Stimulation (14)  ·  Sodium Chloride (11)  ·  Propofol (6)  ·  Amantadine (4)  ·  Dexmedetomidine (4)  ·  Electrocardiography, Ambulatory (4)  ·  Hypothermia, Induced (4)  ·  Midazolam (4)  ·  Midodrine (4)  ·  Saline Solution (4)  ·  Surveys and Questionnaires (4)  ·  Thyroxine (4)  ·  Apomorphine (3)  ·  Blood Specimen Collection (3)  ·  Magnetic Resonance Imaging (3)

Sponsors

Assistance Publique - Hôpitaux de Paris (12)  ·  Hangzhou Normal University (11)  ·  University of Liege (11)  ·  Abbott Medical Devices (9)  ·  Biotronik SE & Co. KG (9)  ·  Hospices Civils de Lyon (9)  ·  University of Calgary (9)  ·  Istituto Auxologico Italiano (8)  ·  Massachusetts General Hospital (7)  ·  National Institute of Neurological Disorders and Stroke (NINDS) (7)  ·  Boston Scientific Corporation (5)  ·  Centre of Postgraduate Medical Education (5)  ·  Medtronic Cardiac Rhythm and Heart Failure (5)  ·  University Hospital, Basel, Switzerland (5)  ·  University of California, Los Angeles (5)

Countries

United States (142)  ·  France (77)  ·  Italy (56)  ·  Canada (46)  ·  China (38)  ·  Germany (30)  ·  Spain (24)  ·  Belgium (23)  ·  United Kingdom (21)  ·  Brazil (18)  ·  Poland (18)  ·  Switzerland (16)  ·  Turkey (Türkiye) (16)  ·  Denmark (15)  ·  Netherlands (15)

Top investigators

Michele Brignole, MD (5)  ·  Haibo Di, Pro. (4)  ·  Haibo Di, Pro (3)  ·  Nicole Harbert (3)  ·  Sandeep Gulati, PhD (3)  ·  Satish R Raj, MD MSCI (3)  ·  Venkatesh Thiruganasambandamoorthy, CCFP-EM, MSc (3)  ·  Victoria E Claydon, PhD (3)  ·  Anar Murphy, PhD (2)  ·  Hamed Tavolinejad, MD (2)  ·  Kenneth M Madden, MD (2)  ·  Kwangdeok Lee (2)

Results publications

PMID 15670960, PMID 21712276, PMID 36114133, PMID 22565936, PMID 38036236, PMID 30354289, PMID 33279955, PMID 19797151, PMID 19954851, PMID 21156950, PMID 21876461, PMID 22224835, PMID 22275485, PMID 24574549, PMID 26411271, PMID 27402231, PMID 27567470, PMID 27683846, PMID 28901969, PMID 29562304, PMID 30338504, PMID 30941094, PMID 31330187, PMID 31439288, PMID 33504514, PMID 34339231, PMID 36467262, PMID 37025684, PMID 37178149, PMID 39198005, PMID 42475649, PMID 10390410, PMID 10634801, PMID 10676584, PMID 10798503, PMID 10869046, PMID 10902039, PMID 11146266, PMID 11210997, PMID 11498461, PMID 12239256, PMID 12243491, PMID 12425407, PMID 12478412, PMID 12625169, PMID 12625171, PMID 12637700, PMID 12709114, PMID 1309182, PMID 1447002

NIH funding

2019 (3), 2017 (2), 2018 (2), R61MH138612 (2), 1UG3HL159134-01 (1), 2014 (1), 2016 (1), 2023 (1), DP2HD101400 (1), K23AG066929 (1), K23HL132052 (1), K23NS136745 (1), K23NS140495 (1), R01AG059613 (1), R01DK091331 (1)