13 completed, 1 recruiting, 1 terminated. 8 Phase 1, 4 Phase 2, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Completed 6, Recruiting 1, Terminated 1 |
| Phase 2 | 4 | Completed 4 |
| Phase 3 | 3 | Completed 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain CNTX-3001, Placebo - Lower Back Pain | Phase 1 | Recruiting | Centrexion Therapeutics | 16 | 2026-03-01 | 2026-03-23 |
| Safety, Tolerability & Pharmacokinetics Study of CNTX-6016 in Healthy Subjects and Subjects With PDN Oral dose CNTX-6016 or oral dose Placebo - Painful Diabetic Neuropathy | Phase 1 | Completed | Centrexion Therapeutics | 46 | 2021-04-14 | 2025-07-28 |
| A Study to Evaluate the Safety and Pharmacokinetics of CNTX-6016 in Healthy Subjects CNTX-6016, Other: Placebo - Chronic Pain, Nociceptive Pain | Phase 1 | Completed | Centrexion Therapeutics | 68 | 2018-12-04 | 2019-11-06 |
| An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA CNTX-4975-05, Lidocaine without epinephrine, ElastoGel - Knee Osteoarthritis | Phase 3 | Completed | Centrexion Therapeutics | 854 | 2018-09-18 | 2022-03-09 |
| A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain Placebo, CNTX-4975-05 - Osteoarthritis, Knee | Phase 3 | Completed | Centrexion Therapeutics | 332 | 2018-09-09 | 2022-07-21 |
| A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis CNTX-4975-05, Qutenza, Lidocaine (without epinephrine) - Knee Osteoarthritis | Phase 1 | Completed | Centrexion Therapeutics | 16 | 2018-06-25 | 2018-11-14 |
| The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin - Osteoarthritis, Knee | Phase 1 | Completed | Centrexion Therapeutics | 20 | 2018-03-21 | 2018-12-19 |
| A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain CNTX-4975-05, Placebo - Osteoarthritis, Knee | Phase 3 | Completed | Centrexion Therapeutics | 332 | 2018-01-24 | 2022-07-26 |
| A Placebo-Controlled, Two-Part Study, Oral Dose to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CNTX-6970 in Healthy Subjects CNTX-6970, Placebo - Chronic Pain, Nociceptive Pain | Phase 1 | Completed | Centrexion Therapeutics | 62 | 2017-08-14 | 2018-12-26 |
| A Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) CNTX-4975 - Morton's Neuroma | Phase 2 | Completed | Centrexion Therapeutics | 67 | 2015-12-01 | 2018-05-09 |
| Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain CNTX-4975, Placebo - Osteoarthritis | Phase 2 | Completed | Centrexion Therapeutics | 175 | 2015-08-01 | 2017-08-08 |
| Study to Evaluate the Safety and Pharmacokinetics of Topically Applied 40% Lidocaine Gel Compared With Placebo in Subjects With Acute Herpes Zoster (Shingles) Pain CNTX-2022 (lidocaine gel, 40%), Placebo - Acute-onset Herpes Zoster Pain | Phase 1 | Terminated | Centrexion Therapeutics | 1 | 2015-01-01 | 2016-02-10 |
| A Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) CNTX-4975, Placebo - Painful Intermetatarsal Neuroma (Morton's Neuroma) | Phase 2 | Completed | Centrexion Therapeutics | 119 | 2014-10-01 | 2016-12-06 |
| Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) CTNX-4975 - Morton's Neuroma | Phase 1 | Completed | Centrexion Therapeutics | 11 | 2014-02-01 | 2015-09-15 |
| Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA) CNTX-4975 - Osteoarthritis of the Knee | Phase 2 | Completed | Centrexion Therapeutics | 54 | 2007-08-01 | 2016-12-06 |
Osteoarthritis (6) · Osteoarthritis, Knee (6) · Morton Neuroma (3) · Pain (3) · Chronic Pain (2) · Nociceptive Pain (2) · Diabetic Neuropathies (1) · Low Back Pain (1)
CNTX-4975 (4) · Capsaicin (4) · Lidocaine (2) · Epinephrine (1) · zucapsaicin (1)
United States (12) · Australia (1) · United Kingdom (1)
Randall M. Stevens, MD (4) · Randall Stevens, MD (3) · Michael Araco, MD (1) · Randall M Stevens, MD (1) · Shaun Comfort, MD, MBA (1) · William C Houghton, MD (1)
1UG3NS123965-01 (1)