894 completed, 285 unknown, 139 recruiting, 134 terminated. 1622 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 1622 | Completed 894, Unknown 285, Recruiting 139, Terminated 134, Not yet recruiting 76, Withdrawn 48, Active not recruiting 32, Enrolling by invitation 11, Suspended 3 |
Follow Brain Diseases: new trials by email Literature Review of Brain Diseases trials Research Report on Brain Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gastrointestinal Dopamine Decarboxylase and Levodopa Pharmacokinetics Levodopa (L-dopa) - Parkinson's Disease | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 40 | 2027-07-01 | 2026-08-28 |
| Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo - Acute Mountain Sickness | Phase 4 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 30 | 2027-06-01 | 2026-07-01 |
| Nortriptyline Compared With Amitriptyline for Migraine Prevention at SQUH Nortriptyline, Amitriptyline - Migraine | Phase 4 | Not yet recruiting | Sultan Qaboos University | 90 | 2027-05-01 | 2026-10-02 |
| Migraine Menopause Study Eptinezumab 100 mg or Eptinezumab 300 mg administered intravenously in 100 mL saline solution, Placebo Normal Saline (NS) - Migraine, Menopausal | Phase 4 | Not yet recruiting | Alberta Neurologic Centre | 120 | 2027-02-01 | 2026-11-04 |
| RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling Intervention 1, Intervention 3, Intervention 2 - Atherosclerosis Cerebral, Carotid Plaque | Phase 4 | Not yet recruiting | Keqiang Zhao | 120 | 2027-01-01 | 2026-09-15 |
| Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine Atogepant 60 mg, Placebo - Migraine Disorders, Brain, Healthy Adult Participants | Phase 4 | Not yet recruiting | Konrad Peter Weber | 80 | 2027-01-01 | 2026-09-17 |
| A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 4 | Not yet recruiting | Elizabeth Donner | 25 | 2027-01-01 | 2026-09-11 |
| Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage Normal Saline, Nicardipine - Subarachnoid Hemorrhage | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 214 | 2027-01-01 | 2026-10-01 |
| Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low Dose Rivaroxaban for Major Adverse Cardiovascular Events Reduction in Ischemic Stroke Rivaroxaban 2.5 Mg Oral Tablet, Colchicine 0.5 MG, Placebo Rivaroxaban - Ischemic Stroke | Phase 4 | Not yet recruiting | Brazilian Clinical Research Institute | 4500 | 2027-01-01 | 2026-10-30 |
| Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms Methylprednisolone (Injectable Form), Placebo Injection - Unruptured Intracranial Aneurysms, Cerebrovascular Event | Phase 4 | Not yet recruiting | Duan Chuanzhi | 864 | 2026-11-30 | 2026-10-26 |
| A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS Cannabidiol Oral Solution - Lennox-Gastaut Syndrome | Phase 4 | Not yet recruiting | Jazz Pharmaceuticals | 40 | 2026-11-18 | 2026-10-22 |
| Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease mirabegron, Exercise-based behavioral therapy - Overactive Bladder, Parkinson Disease | Phase 4 | Not yet recruiting | VA Office of Research and Development | 146 | 2026-11-09 | 2026-10-27 |
| Lumbrokinase vs Placebo in Moderate-to-Severe Ischemic Stroke Lumbrokinase, Lumbrokinase Placebo - Ischemic Stroke, Acute | Phase 4 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1196 | 2026-11-01 | 2026-08-13 |
| A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease Donanemab - Alzheimer Disease | Phase 4 | Not yet recruiting | Eli Lilly and Company | 50 | 2026-11-01 | 2026-10-15 |
| Propofol Target-Controlled Infusion Versus Dexmedetomidine for Sedation During Chronic Subdural Hematoma Surgery Under Local Anesthesia Dexmedetomidine, Propofol (Astra-Zeneca) - Chronic Subdural Hematoma | Phase 4 | Not yet recruiting | National Institute of Neurology, Tunisia | 60 | 2026-11-01 | 2026-11-03 |
| Effectiveness and Tolerability of a Treat-to-Target Versus Fixed-Dose Statin Strategy in Patients With Atherosclerotic Cardiovascular Disease Dose adjustment of statins, no dose adjustment - Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA | Phase 4 | Not yet recruiting | Rehman Medical Institute - RMI | 178 | 2026-11-01 | 2026-11-05 |
| Oral Anticoagulation in Patients With Prior Deep Intracerebral Hemorrhage, Atrial Fibrillation, and Ischemic Stroke Apixaban, No Oral Anticoagulation Strategy - Intracerebral Hemorrhage, Atrial Fibrillation (AF) | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 852 | 2026-10-26 | 2026-10-20 |
| Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment Metoclopramide 10mg, Acetaminophen - Concussion Post Syndrome, Head Trauma Injury | Phase 4 | Not yet recruiting | Montefiore Medical Center | 200 | 2026-10-01 | 2026-10-01 |
| Anti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein Complex Magnesium sulfate (MgSO4), Normal Saline - Traumatic Brain Injuries | Phase 4 | Not yet recruiting | Assiut University | 64 | 2026-10-01 | 2026-08-13 |
| Tirofiban Combined With Aspirin in Moderate Ischemic Stroke Tirofiban, Tirofiban-matching placebo - Ischemic Stroke, Acute | Phase 4 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1168 | 2026-10-01 | 2026-08-12 |
Showing 20 of 1622. Sign in to see all of them.
Stroke (232) · Parkinson Disease (172) · Migraine Disorders (159) · Ischemic Stroke (149) · Alzheimer Disease (137) · Epilepsy (117) · Dementia (73) · Brain Injuries, Traumatic (60) · Cognitive Dysfunction (46) · Headache (42) · Seizures (39) · Atrial Fibrillation (38) · Hepatic Encephalopathy (35) · Brain Neoplasms (34) · Brain Injuries (32)
Central Nervous System Diseases (1617) · Nervous System Diseases (1612) · Vascular Diseases (551) · Cardiovascular Diseases (544) · Cerebrovascular Disorders (522) · Pathological Conditions, Signs and Symptoms (476) · Neurodegenerative Diseases (350) · Mental Disorders (288) · Signs and Symptoms (252) · Pathologic Processes (249) · Neurologic Manifestations (224) · Neurocognitive Disorders (222) · Basal Ganglia Diseases (201) · Movement Disorders (200)
Aspirin (58) · Clopidogrel (44) · Saline Solution (40) · Sodium Chloride (37) · Donepezil (36) · Levetiracetam (36) · Memantine (34) · Botulinum Toxins, Type A (30) · Topiramate (30) · Atorvastatin (29) · Dexmedetomidine (27) · Propofol (23) · erenumab (21) · Cilostazol (20) · Methylphenidate (18)
Pfizer (25) · Genzyme, a Sanofi Company (22) · Novartis Pharmaceuticals (18) · Novartis (17) · Beijing Tiantan Hospital (15) · Seoul National University Hospital (14) · Mayo Clinic (13) · GlaxoSmithKline (12) · Montefiore Medical Center (12) · VA Office of Research and Development (12) · Eisai Korea Inc. (11) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (11) · UCB Pharma (11) · Amgen (10) · Asan Medical Center (10)
United States (548) · China (215) · South Korea (99) · Germany (95) · France (94) · Canada (83) · Spain (81) · Italy (76) · United Kingdom (74) · Denmark (44) · Netherlands (40) · Poland (37) · Austria (35) · India (34) · Australia (33)
Roger K Cady, MD (10) · Jihee Mun (6)
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