97 completed, 48 unknown, 21 recruiting, 16 not yet recruiting. 60 Not applicable, 39 Phase 2, 35 Phase 4, 24 Phase 3, 16 Phase 1.
Follow Hepatic Encephalopathy: new trials by email Literature Review of Hepatic Encephalopathy trials Research Report on Hepatic Encephalopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE) Microbiota transplant therapy (MTT) capsules, Placebo capsule - Hepatic Encephalopathy, Cirrhosis | Phase 2 | Not yet recruiting | VA Office of Research and Development | 162 | 2026-10-30 | 2026-04-14 |
| Pre-emptive RTO for An Early Detected Gastric Varices in CT/MR Angiogram Trial Non-selective beta blockers, Retrograde transvenous obliteration - Gastric Varices | Not applicable | Not yet recruiting | University of California, Los Angeles | 68 | 2026-10-01 | 2026-07-02 |
| Electronic PHES vs Paper-based PHES for Hepatic Encephalopathy Paper-based Psychometric Hepatic Encephalopathy Score (PHES), Electronic Psychometric Hepatic Encephalopathy Score (PHES) - Liver Cirrhosis, Hepatic Encephalopathy | Not applicable | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 80 | 2026-10-01 | 2026-10-01 |
| A Prospective Cohort Study on the Epidemiological Investigation, Diagnosis, and Treatment of Hepatic Encephalopathy wechat mini-program - Hepatic Encephalopathy, Minimal Hepatic Encephalopathy | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 700 | 2026-10-01 | 2026-10-01 | |
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| Equivalence of Electronic vs Paper-based PHES in Diagnosing Hepatic Encephalopathy Paper-based PHES, Electronic PHES - Liver Cirrhosis, Hepatic Encephalopathy (HE) | Not applicable | Not yet recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 80 | 2026-10-01 | 2026-10-14 |
| Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis Daridorexant, Placebo - Liver Cirrhosis, Sleep Disturbance | Phase 4 | Not yet recruiting | Wang Fengmei | 180 | 2026-09-01 | 2026-10-16 |
| Coil-Assisted Small-Diameter Covered-Stent Shunt Reduction for Refractory Hepatic Encephalopathy After TIPS Coil-assisted Small-diameter Stent Shunt reduction - Hepatic Encephalopathy, Transjugular Intrahepatic Portosystemic Shunt (TIPS) | Not applicable | Recruiting | Air Force Military Medical University, China | 30 | 2026-09-01 | 2026-09-02 |
| 4D-Flow MRI Assessment of Portal Hypertension and TIPS Outcomes in Cirrhosis 4D-Flow Liver and heart MRI with Gadolinium injection, Samples Without DNA - Cirrhosis, Portal Hypertension | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-08-25 | 2026-10-13 |
| Underdilated VCX-TIPS Versus EVL Plus NSBB for Secondary Prophylaxis of Variceal Bleeding in Cirrhosis Underdilated VCX-TIPS, Endoscopic Variceal Ligation, Nonselective Beta-Blockers - Liver Cirrhosis, Portal Hypertension | Not applicable | Not yet recruiting | West China Hospital | 240 | 2026-08-01 | 2026-05-14 |
| Fecal Microbiota Transplantation for the Treatment of Refractory Hepatic Encephalopathy After TIPS Surgery Fecal Microbiota Transplantation, Rifaximin、Lactulose, Dietary Fiber Prebiotic - Hepatic Encephalopathy, Fecal Microbiota Transplantation | Early Phase 1 | Recruiting | Air Force Military Medical University, China | 26 | 2026-06-01 | 2026-07-06 |
| Endoscopic Shunts Embolization for Refractory Hepatic Encephalopathy Endoscopic ultrasound-guided transgastric embolization of the spontaneous portosystemic shunts, Interventional Radiology for shunt embolization/retrograde tranvenous obliteration - Hepatic Encephalopathy, Liver Cirrhosis | Not applicable | Not yet recruiting | Rutgers, The State University of New Jersey | 34 | 2026-05-01 | 2026-04-28 |
| Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis Apixaban, Carvedilol, Placebo - Cirrhosis, Esophageal and Gastric Varices | Phase 4 | Recruiting | Asian Institute Of Medical Sciences | 220 | 2026-04-01 | 2026-04-09 |
| Evaluation of the Outcome of Fecal Microbiota Transplantation Fecal Microbiota Transplantation, FMT Matched Placebo, Rifaximin、Lactulose - Hepatic Encephalopathy, Fecal Microbiota Transplantation | Phase 1 / Phase 2 | Not yet recruiting | Air Force Military Medical University, China | 40 | 2026-03-07 | 2026-03-06 |
| Development of a Cognitive Tool for Rapid and Reliable Screening of Minimal Hepatic Encephalopathy: Pilot Study Cognitive test - Hepatic Pathology (Fibrosis, Cirrhosis, Porto Systemic Shunts) | Recruiting | Assistance Publique - Hôpitaux de Paris | 100 | 2026-01-29 | 2026-02-18 | |
| UDCA to Prevent Post-TIPS Hepatic Encephalopathy Ursodeoxycholic Acid (UDCA), Lactulose - Hepatic Encephalopathy (HE), TIPS | Not applicable | Not yet recruiting | West China Hospital | 270 | 2026-01-01 | 2025-12-09 |
| The Liver Cirrhosis Cognitive Decline Scale (LiCCoS) Liver Cirrhosis, Cognitive Dysfunction | Recruiting | University of Malaya | 230 | 2025-12-15 | 2026-02-18 | |
| Appropriate Management of Hepatic EncePhalopaThy AmonG cirrhOtic patieNts Admitted to Internal Medicine Cirrhoses, Liver, Portal Hypertension Related to Cirrhosis | Active not recruiting | Fadoi Foundation, Italy | 400 | 2025-12-05 | 2026-07-27 | |
| Comparison of Underdilated Versus Standard TIPS in Preventing Variceal Rebleeding in Patients With Cirrhosis Underdilated TIPS, Standard TIPS - Liver Cirrhosis, Gastroesophageal Varices Bleeding | Not applicable | Recruiting | Air Force Military Medical University, China | 648 | 2025-10-20 | 2026-06-09 |
| Study on Proteomic and Microbiome Changes in Patients With Hepatic Encephalopathy (HE) Cirrhoses, Liver, Hepatic Encephalopathy (HE) | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 32 | 2025-09-01 | 2025-09-25 |
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Fibrosis (66) · Liver Cirrhosis (59) · Hypertension, Portal (19) · Liver Diseases (17) · Ascites (12) · Acute-On-Chronic Liver Failure (11) · Brain Diseases (9) · Liver Failure (9) · End Stage Liver Disease (7) · Liver Failure, Acute (7) · Hepatic Insufficiency (6) · Esophageal and Gastric Varices (5) · Sarcopenia (4) · Hepatitis C (3)
Nutritional and Metabolic Diseases (217) · Brain Diseases, Metabolic (216) · Central Nervous System Diseases (216) · Digestive System Diseases (216) · Metabolic Diseases (216) · Nervous System Diseases (216) · Hepatic Insufficiency (211) · Brain Diseases (208) · Liver Failure (208) · Liver Diseases (200) · Pathological Conditions, Signs and Symptoms (120) · Pathologic Processes (117) · Fibrosis (46) · Infections (11) · Mental Disorders (11)
Lactulose (36) · Rifaximin (26) · Fecal Microbiota Transplantation (10) · ornithylaspartate (10) · Albumins (6) · Amino Acids, Branched-Chain (5) · Amino Acids (3) · Blood Specimen Collection (3) · Polyethylene Glycols (3) · nitazoxanide (3) · polyethylene glycol 3350 (3) · AST 120 (2) · Acetylcarnitine (2) · Carvedilol (2) · Glucose (2)
Hunter Holmes Mcguire Veteran Affairs Medical Center (8) · Post Graduate Institute of Medical Education and Research, Chandigarh (7) · Bausch Health Americas, Inc. (6) · Air Force Military Medical University, China (5) · Assistance Publique - Hôpitaux de Paris (5) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (5) · NYU Langone Health (5) · University of Aarhus (5) · University of Michigan (5) · Govind Ballabh Pant Hospital (4) · Hospital Universitari Vall d'Hebron Research Institute (4) · Aga Khan University (3) · Amgen (3) · Institute of Liver and Biliary Sciences, India (3) · The First Affiliated Hospital with Nanjing Medical University (3)
United States (68) · China (24) · India (23) · Spain (14) · Egypt (13) · Italy (12) · United Kingdom (12) · Canada (11) · Denmark (10) · France (10) · Mexico (10) · Belgium (6) · Pakistan (6) · Germany (5) · Australia (4)
Barjesh C Sharma, MD,DM (3) · Elliot Tapper, MD (3) · Lindsey Mathew (3) · Patricia Bloom, MD (3) · Aldo Torre Delgadillo, M.D. M.Sc (2) · Jasmohan Bajaj, MD (2) · Jasmohan S. Bajaj, MD MS (2) · Jun Tie (2) · Michael Mader (2)
PMID 37467180, PMID 20335583, PMID 23872605, PMID 27720916, PMID 28506905, PMID 31038755, PMID 35313729, PMID 38349709, PMID 10051463, PMID 10898704, PMID 14762784, PMID 15789368, PMID 15791615, PMID 16024550, PMID 16737880, PMID 16950959, PMID 17006913, PMID 17326150, PMID 17685471, PMID 17975845, PMID 18643912, PMID 18775022, PMID 19643443, PMID 20036625, PMID 20203603, PMID 20512995, PMID 20849805, PMID 21157444, PMID 21310833, PMID 21484318, PMID 21621221, PMID 21848797, PMID 21940902, PMID 21975221, PMID 22321469, PMID 22527995, PMID 22699609, PMID 22728514, PMID 22861074, PMID 22906509, PMID 23111765, PMID 23224378, PMID 23260095, PMID 23297006, PMID 23425082, PMID 23439908, PMID 23474284, PMID 23565181, PMID 23847109, PMID 23939627
2018 (2), U01DK072146 (2), 2008 (1), 2014 (1), 2019 (1), 2025 (1), P30AG024824 (1), P30DK034989 (1), R21DK117431 (1), R21TR002024 (1), U01AT004428 (1), U01DK058369 (1), U01DK062436 (1)