77 completed, 24 unknown, 16 not yet recruiting, 14 recruiting. 99 Not applicable, 10 Phase 2, 6 Phase 3, 6 Phase 4, 4 Early Phase 1.
Follow Apical Periodontitis: new trials by email Literature Review of Apical Periodontitis trials Research Report on Apical Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2027-07-01 | 2026-04-08 |
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| Apical Periodontitis and Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population Apical Periodontitis | Not yet recruiting | Cairo University | 88 | 2026-10-05 | 2026-10-02 | |
| Endodontic Microsurgery Platelet rich fibrin - Apical Periodontitis | Phase 4 | Not yet recruiting | Mark Schachman | 20 | 2026-10-01 | 2026-07-29 |
| Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation sonically activated irrigation, laser activated irrigation, conventional needle irrigation - Apical Periodontitis, Post Operative Pain, Acute | Not applicable | Not yet recruiting | University Ghent | 183 | 2026-10-01 | 2026-10-20 |
| Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5% - Pulp Necrosis, Apical Periodontitis | Not applicable | Recruiting | October 6 University | 60 | 2026-10-01 | 2026-10-27 |
| Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste - Apical Periodontitis, Post Endodontic Pain | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 50 | 2026-08-30 | 2026-08-13 |
| Biomarkers in Apical Periodontitis laser activation, PUI, CSI - Apical Periodontitis, Retreatment | Not applicable | Completed | Kırıkkale University | 66 | 2026-08-30 | 2026-10-21 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Effect of Different Apical Motion Algorithms on Postoperative Pain After Root Canal Treatment Root Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation - Apical Periodontitis, Postoperative Pain After Endodontic Treatment | Not applicable | Recruiting | Alanya Alaaddin Keykubat University | 120 | 2026-08-20 | 2026-10-27 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Postoperative Pain After OCT or EDTA Irrigation in Regenerative Endodontic Treatment Regenerative Endodontic Treatment Using Different Irrigation Solutions - Apical Periodontitis, Endodontic Disease | Not applicable | Completed | TC Erciyes University | 40 | 2026-04-10 | 2026-10-23 |
| The Present Study Aims to Follow up on All Root Canal Treatments Performed During the Year 2023 Within the Public Dental Services of the Counties of Jönköping, Kalmar, and Östergötland, Sweden. The Study is Entirely Observational in Nature. Endodontic Treatment, Apical Periodontitis | Not yet recruiting | Region Jönköping County | 1500 | 2026-03-01 | 2025-12-16 | |
| Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis Apical Periodontitis | Not yet recruiting | Duygu Degirmencioglu | 45 | 2026-03-01 | 2026-01-20 | |
| Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth. Allium Sativum as an intracanal medicament - Apical Periodontitis, Periapical Radiolucency | Phase 3 | Not yet recruiting | University of Health Sciences Lahore | 96 | 2026-01-20 | 2026-01-06 |
| Retreatment and Diabetes root canal retreatment - Apical Periodontitis | Not applicable | Completed | TC Erciyes University | 50 | 2026-01-01 | 2026-07-01 |
| N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC) - Apical Periodontitis | Phase 2 | Active not recruiting | Alexandria University | 40 | 2025-11-15 | 2025-12-30 |
| Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France Pulpitis - Irreversible, Pulp Necrosis | Recruiting | University Hospital, Strasbourg, France | 100 | 2025-11-07 | 2026-03-03 | |
| In Vivo-Ex Vivo Evaluation of the Root ZX3 for Working-Length Determination Root ZX3 Electronic Apex Locator - Apical Periodontitis, Pulp Disease, Dental | Not applicable | Completed | Riyadh Elm University | 41 | 2025-10-19 | 2026-07-08 |
| To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis Full pulpotomy in adults ≥18 years with restorable mandibular first or second molars diagnosed with irreversible pulpitis, with or without apical periodontitis. - Apical Periodontitis | Not applicable | Not yet recruiting | Postgraduate Institute of Dental Sciences Rohtak | 128 | 2025-10-15 | 2025-09-18 |
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Periapical Periodontitis (145) · Pain, Postoperative (29) · Dental Pulp Necrosis (20) · Dental Pulp Diseases (6) · Pain (5) · Dental Caries (4) · Periapical Diseases (4) · Pulpitis (4) · Tooth, Nonvital (4) · Diabetes Mellitus (3) · Diabetes Mellitus, Type 2 (3) · Radicular Cyst (3) · Inflammation (2) · Periapical Granuloma (2) · Anxiety Disorders (1)
Jaw Diseases (145) · Periodontal Diseases (145) · Periodontitis (145) · Stomatognathic Diseases (145) · Mouth Diseases (144) · Periapical Diseases (141) · Pathological Conditions, Signs and Symptoms (50) · Pathologic Processes (48) · Tooth Diseases (35) · Neurologic Manifestations (33) · Signs and Symptoms (33) · Pain (28) · Postoperative Complications (28) · Dental Pulp Diseases (25) · Necrosis (19)
Sodium Hypochlorite (6) · Endodontics (4) · Calcium Hydroxide (3) · Carticaine (3) · Edetic Acid (3) · Oxymetazoline (3) · Sodium Chloride (3) · Tetracaine (3) · Therapeutic Irrigation (3) · Chlorhexidine (2) · Control Groups (2) · Diclofenac (2) · Ferrosoferric Oxide (2) · Lasers, Semiconductor (2) · Methods (2)
Postgraduate Institute of Dental Sciences Rohtak (18) · Cairo University (10) · TC Erciyes University (5) · University of Siena (5) · University of Pennsylvania (4) · Biruni University (3) · Isparta Military Hospital (3) · Istanbul Medipol University Hospital (3) · Kırıkkale University (3) · Recep Tayyip Erdogan University (3) · Virginia Commonwealth University (3) · Ain Shams University (2) · Dow University of Health Sciences (2) · Kahramanmaras Sutcu Imam University (2) · Marmara University (2)
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