19 completed, 4 unknown, 3 not yet recruiting, 3 recruiting. 18 Not applicable, 6 Phase 2, 6 Phase 3, 4 Phase 1, 3 Phase 4.
Follow Edetic Acid: new trials by email Literature Review of Edetic Acid trials Research Report on Edetic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alb-PRF as an Adjunct to Regenerative Periodontal Surgery Regenerative Periodontal Surgery With EDTA and Allogeneic Bone Graft, Albumin Platelet-Rich Fibrin - Periodontitis, Periodontitis Stage III | Not applicable | Not yet recruiting | Halil Ata BIÇAKÇIOĞLU | 24 | 2027-01-01 | 2026-09-04 |
| Efficacy of Temocillin Compared to Standard of Care in the Treatment of Neisseria Gonorrhoeae Infections Temocillin (NEGABAN®) 2 g intravenous with lidocaine (3ml), Rectal swab for ESBL-E and microbiota (Eswab), Temocillin (NEGABAN®) 2 g intramuscular single dose with lidocaine (3ml) - Neisseria Gonorrhoeae (Ng) Infections | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 360 | 2026-09-01 | 2026-06-22 |
| Regenerative Endodontics in Mature Necrotic Teeth Intervention 1: 1% nanochitosan, Intervention 2: 1% nanochitosan & 17% EDTA - Necrotic Teeth With Chronic Apical Periodontitis | Not applicable | Not yet recruiting | Suez Canal University | 60 | 2026-08-01 | 2026-06-03 |
| To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse. 0.12% CHX and Essential Oil mouthrinse, 2.6% EDTA and 0.2% EDTA mouth rinse - Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth | Not applicable | Recruiting | University of Alabama at Birmingham | 40 | 2026-03-02 | 2026-03-20 |
| Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis Final irrigation with 2.5% NaOCl and 17% EDTA, Final irrigation with 2.5% NaOCl and 9% HEBP, Irrigation with 2.5% NaOCl-9% HEBP during both preparation and final irrigation - Chronic Apical Periodontitis | Not applicable | Active not recruiting | Mustafa Kemal University | 63 | 2025-12-01 | 2026-01-23 |
| Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative Flapless instrumentation of the defect following MINST in conjuction with NaOCl and hyaluronic acid application, Flapless instrumentation of the defect following MINST, root conditioning with EDTA and EMD application, Flapless instrumentation of the defect and product application simulation - Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use | Not applicable | Recruiting | University of Valencia | 60 | 2024-10-26 | 2026-08-19 |
| A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects Connective Tissue Graft (CTG) Wall Technique, Minimally Invasive Flap Design, Root Surface Preparation and Debridement - Periodontal Diseases, Regeneration | Not applicable | Completed | Phạm Đình Thiên Khải | 17 | 2024-06-01 | 2025-11-18 |
| Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments - Endodontic Disease | Phase 4 | Unknown | TC Erciyes University | 39 | 2024-01-01 | 2024-04-26 |
| PRF and CGF Scaffolds With EDTA in Regeneration Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA - Pulp Necrosis, Immature Permanent Teeth | Not applicable | Completed | Kahramanmaras Sutcu Imam University | 30 | 2023-10-01 | 2025-12-12 |
| Effect of Different Irrigation Protocols on Postoperative Endodontic Pain and Inflammation EDTA, Etidronate, clodronate - Irrigation Solution, Postoperative Pain | Not applicable | Active not recruiting | Suez Canal University | 75 | 2023-08-20 | 2025-08-11 |
| Role Of Wound Lavage in Direct Pulp Capping Of Permanent Teeth With Carious Exposure wound lavage with normal saline, wound lavage with sodium hypochlorite, wound lavage with Ethylenediaminetetraacetic acid(EDTA) - Reversible Pulpitis | Not applicable | Unknown | Postgraduate Institute of Dental Sciences Rohtak | 140 | 2022-11-01 | 2023-12-08 |
| EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions EDTA, Abreva - Herpes Simplex Oral | Phase 2 | Completed | University of Utah | 10 | 2022-01-20 | 2025-10-31 |
| Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion. Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite - Root Canal Infection, Periapical Abscess | Not applicable | Completed | Dow University of Health Sciences | 100 | 2021-11-16 | 2023-10-26 |
| Evaluation of Sticky Bone With or Without EDTA for Treatment of Gingival Recession Sticky bone and EDTA, Sticky bone - Gingival Recession | Not applicable | Unknown | Kafrelsheikh University | 20 | 2021-08-03 | 2024-04-11 |
| Ethanolic Extract of Sapindus Mukorrossi as Final Endodontic Irrigant. ethanolic extract of sapindus mukorossi, ethylene diamine tetra acetic acid - Irreversible Pulpitis, Apical Periodontitis | Not applicable | Completed | Dow University of Health Sciences | 90 | 2020-04-02 | 2021-09-08 |
| Effect of Different Final Irrigation Protocols on Postoperative Endodontic Pain in Devital Teeth EDTA and CHX Solution, EDTA Solution, CHX Solution - Postoperative Pain, Endodontically Treated Teeth | Not applicable | Completed | Istanbul Medipol University Hospital | 90 | 2019-09-01 | 2020-04-07 |
| Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy Edetate Calcium Disodium, Multivitamin, Succimer - Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 58 | 2018-10-11 | 2026-09-18 |
| A Study to Evaluate the Efficacy and Safety of ORMD-0801 (Oral Insulin) in Patients With Type 2 Diabetes Mellitus Cohort A: ORMD-0801, Placebo oral capsule, Cohort B: ORMD-0801 - T2DM (Type 2 Diabetes Mellitus) | Phase 2 | Completed | Oramed, Ltd. | 373 | 2018-05-29 | 2022-11-08 |
| Minimally Invasive Flap With Platelet Rich Fibrin or Growth Factor Enhanced Matrix in Treatment of Intrabony Defect Minimal invasive flap technique, Minimally invasive flap with root conditioning (EDTA) and platelet rich fibrin, minimally invasive flap with root contioning by EDTA and growth factor enhanced matrix GEM21S - Periodontal Regeneration | Phase 2 | Completed | Tanta University | 21 | 2018-01-01 | 2021-06-18 |
| Prolonged Gadolinium Retention After MRI Imaging edetate calcium disodium - Heavy Metal Toxicity | Phase 4 | Withdrawn | Mt. Sinai Medical Center, Miami | 2017-07-01 | 2017-08-29 |
Showing 20 of 36. Sign in to see all of them.
Periapical Periodontitis (4) · Infections (3) · Pain, Postoperative (3) · Alveolar Bone Loss (2) · Bacterial Infections (2) · Blast Crisis (2) · Chronic Periodontitis (2) · Dental Pulp Diseases (2) · Dental Pulp Necrosis (2) · Leukemia, Myeloid, Acute (2) · Myelodysplastic Syndromes (2) · Myelodysplastic-Myeloproliferative Diseases (2) · Myeloproliferative Disorders (2) · Periodontitis (2) · Anemia, Iron-Deficiency (1)
Mt. Sinai Medical Center, Miami (4) · Dow University of Health Sciences (3) · Ain Shams University (2) · Assistance Publique - Hôpitaux de Paris (2) · M.D. Anderson Cancer Center (2) · Postgraduate Institute of Dental Sciences Rohtak (2) · Suez Canal University (2) · Cumberland Pharmaceuticals (1) · Halil Ata BIÇAKÇIOĞLU (1) · Istanbul Medipol University Hospital (1) · Kafrelsheikh University (1) · Kahramanmaras Sutcu Imam University (1) · Leonard-Meron Biosciences, Inc. (1) · Mehmet Kemal Çalışkan (1) · Mustafa Kemal University (1)
United States (11) · Turkey (Türkiye) (5) · Egypt (4) · Pakistan (3) · France (2) · India (2) · Brazil (1) · Canada (1) · Ghana (1) · Puerto Rico (1) · Spain (1) · Switzerland (1) · Vietnam (1)
A.K. Deb (1) · Ahmed Y Gamal, Professor (1) · Aliye Kamalak (1) · Araib AT Tahir, BDS (1) · Art Wheeler, MD (1) · Christopher M Hull, M.D. (1) · Dalia Abdallah (1) · Dalia Fayyad (1) · Dalia R Issa, PhD (1) · Daniel B Mark, MD (1) · Deepak Dewan (1) · Dharamraj Maurya (1)
PMID 22172430, PMID 23532240, PMID 24254885, PMID 24490264, PMID 24844029, PMID 24987051, PMID 31433059, PMID 32446881, PMID 35750221, PMID 37571801, PMID 39141382, PMID 39815035, PMID 39875846, PMID 40029647, PMID 40275217, PMID 40835176
2025 (1), R01AT009273 (1), U01AT001156 (1), U01HL092607 (1), U24AT009150 (1), UH3AT009149 (1), UH3AT009150 (1)