40 completed, 17 unknown, 9 recruiting, 8 not yet recruiting. 46 Not applicable, 14 Phase 2, 12 Phase 3, 8 Phase 4, 5 Early Phase 1.
Follow Calcium Hydroxide: new trials by email Literature Review of Calcium Hydroxide trials Research Report on Calcium Hydroxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste - Dental Pulp Necrosis, Periapical Diseases | Not applicable | Not yet recruiting | Cairo University | 50 | 2027-01-01 | 2026-08-19 |
| Effect of Cyperus Articulatus on Bacterial Reduction and Postoperative Pain Cyperus articulatus - Chronic Apical Periodontitis | Not applicable | Recruiting | Minia University | 60 | 2026-09-25 | 2026-10-23 |
| Effect of a Herbal Intracanal Medication On Postoperative Pain And Flare up Incidence In Non Surgical Root Canal Retreatment Calcium hydroxide, Propolis Extract, Green Tea Polyphenolics (EGCG) - Postoperative Pain, Flare Up, Symptom | Not applicable | Not yet recruiting | Minia University | 40 | 2026-07-01 | 2026-05-11 |
| Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2) - Periapical Lesion, Periapical Periodontitis | Not applicable | Not yet recruiting | Faiz ur rahman | 62 | 2026-06-15 | 2026-03-18 |
| Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis Calcium Hydroxide (Ca(OH)2), Bioceramic Intracanal Medicament - Symptomatic Apical Periodontitis | Not applicable | Recruiting | Future University in Egypt | 28 | 2026-06-01 | 2026-09-25 |
| Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication - Intervention Studies, ASA Physical Status I | Phase 1 | Recruiting | Ain Shams University | 60 | 2026-06-01 | 2026-06-12 |
| Evaluation of Postoperative Pain and Bacterial Load After Hyalone or Calcium Hydroxide Medication in Mandibular First Molars Hyalone, Calcium Hydroxide (Ca(OH)2) Intracanal Medication - Bacterial Load Reduction, Postoperative Pain | Phase 2 | Active not recruiting | Future University in Egypt | 28 | 2026-06-01 | 2026-08-20 |
| Comparing the Effectiveness of Hyalone and Calcium Hydroxide in Reducing Post-operative Pain and Promoting Periapical Healing. Hyalone, Calcium Hydroxide (Ca(OH)2) Intracanal Medication - Pain Management | Early Phase 1 | Active not recruiting | Future University in Egypt | 24 | 2026-04-05 | 2026-09-16 |
| Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp. 1% melatonin gel, Calcium Hydroxide (Ca(OH)2) - Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp | Not applicable | Not yet recruiting | Cairo University | 50 | 2026-03-22 | 2026-03-27 |
| Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain Calcium Hydroxide (Ca(OH)2), chitosan nanoparticles gel - Pulp Necrosis | Phase 4 | Not yet recruiting | Ain Shams University | 52 | 2026-02-01 | 2026-02-05 |
| The Effect of Different Intra-canal Medications on Postoperative Pain ibuprofen, Nitrofurantoin, Calcium Hydroxide - Pulp Necrosis, Apical Periodontitis | Early Phase 1 | Recruiting | Cairo University | 111 | 2025-12-15 | 2026-07-21 |
| N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC) - Apical Periodontitis | Phase 2 | Active not recruiting | Alexandria University | 40 | 2025-11-15 | 2025-12-30 |
| The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament Diclofenac Sodium, Calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Recruiting | British University In Egypt | 48 | 2025-11-01 | 2025-05-30 |
| Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2) - Immature Permanent Teeth With Open Apex, Pulp Necrosis | Not applicable | Active not recruiting | Mansoura University | 20 | 2025-10-01 | 2026-01-28 |
| A Study Comparing Eggshell Based and Gold Standard Materials to Heal Deep Tooth Damage in Adult Molars eggshell-derived calcium hydroxyapatite, Calcium hydroxide - Indirect Pulp Cap | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 54 | 2025-09-20 | 2025-09-19 |
| The Efficiency of 810 nm Diode Laser on Periapical Healing After Root Canal Retreatment diode laser, Calcium Hydroxide (Ca(OH)2) - This Study Will be Performed to Evaluate the Efficiency of 810 nm Diode Laser Disinfection on Periapical Healing in Root Canal Retreatment Cases | Not applicable | Recruiting | Al-Azhar University | 40 | 2025-09-19 | 2025-09-30 |
| The Effect of Different Intracanal Medicaments on Periapical Lesion Healing Diclofenac sodium - Periapical Lesion Healing, Apical Periodontitis | Not applicable | Recruiting | Mustafa Kemal University | 60 | 2025-09-15 | 2026-10-07 |
| Comparison of Postoperative Pain After Double Antibiotic Paste vs Calcium Hydroxide in Teeth With Symptomatic Apical Periodontitis Calcium Hydroxide (Ca(OH)2), Double Antibiotic Paste - Symptomatic Apical Periodontitis | Not applicable | Recruiting | College of Physicians and Surgeons Pakistan | 662 | 2025-09-05 | 2026-10-09 |
| Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth Egyptian MTA, Biodentine, Calcium Hydroxide (Ca(OH)2) - Deep Caries, Indirect Pulp Capping | Phase 4 | Recruiting | Cairo University | 35 | 2025-09-03 | 2026-03-18 |
| Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial Calcium Hydroxide Intracanal medication, mesoporous silica nanoparticles paste, Calcium Hydroxide + mesoporous silica nanoparticles - Necrotic Pulp | Not applicable | Active not recruiting | Future University in Egypt | 42 | 2025-09-01 | 2026-01-08 |
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Pain, Postoperative (16) · Periapical Periodontitis (12) · Dental Pulp Necrosis (11) · Dental Caries (6) · Dental Pulp Diseases (4) · Dental Pulp Exposure (3) · Pain (2) · Toothache (2) · Agnosia (1) · Camurati-Engelmann Syndrome (1) · Communicable Diseases (1) · Dentin, Secondary (1) · Infections (1) · Necrosis (1) · Periapical Abscess (1)
Cairo University (18) · Mansoura University (7) · Future University in Egypt (4) · Ain Shams University (3) · Ataturk University (3) · British University In Egypt (2) · Ege University (2) · Minia University (2) · Mustafa Kemal University (2) · Pakistan Institute of Medical Sciences (2) · Al-Azhar University (1) · Alexandria University (1) · Altamash Institute of Dental Medicine (1) · Altinbas University (1) · Aqsa Afzal (1)
Egypt (29) · Pakistan (10) · Turkey (Türkiye) (6) · Saudi Arabia (3) · United States (3) · Brazil (1) · Chile (1) · France (1) · Iran (1) · Jordan (1) · Singapore (1) · Sweden (1)
Shehab Eldin M Saber, doctoral (2) · Adel Abdelwahed, Prof. Ass. of endodontic (1) · Ahmed M Abd Alsamad, PHD (1) · Amany Badr, Prof (1) · Amany Badr, Professor (1) · Aya Ad Hamza, Phd (1) · Beenish Qureshi, BDS, FCPS (1) · Ceren Yeniay (1) · Claudia Brizuela (1) · Eman M. Hassan (1) · Fazal R Qazi (1)
PMID 16805357, PMID 17571933, PMID 21496656, PMID 21752247, PMID 22838228, PMID 23690353, PMID 24756324, PMID 25467231, PMID 31096259, PMID 33088056, PMID 37920592, PMID 38054133, PMID 38616424, PMID 40155539, PMID 40466913, PMID 41091393, PMID 41206809, PMID 41272686, PMID 41814304, PMID 41952147, PMID 42750035
U01DE016750 (1)