30 completed, 14 unknown, 7 not yet recruiting, 4 active not recruiting. 41 Not applicable, 10 Phase 4, 7 Phase 2, 5 Phase 3, 4 Phase 1.
Follow Sodium Hypochlorite: new trials by email Literature Review of Sodium Hypochlorite trials Research Report on Sodium Hypochlorite
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Postoperative Pain and the Antimicrobial Effect of Super Oxidized Water (Microcyn) and Chlorhexidine When Compared With Sodium Hypochlorite in Teeth With Asymptomatic Necrotic Pulps. A Randomized Clinical Trial super-oxidized water (Microcyn) irrigating solution, 2% chlorhexidine irrigating solution, 2.5% sodium hypochlorite - Evaluation of Postoperative Pain and Antimicrobial Efficacy | Not applicable | Not yet recruiting | Cairo University | 75 | 2026-11-02 | 2026-10-01 |
| Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment. Sodium Hypochlorite 3% Solution, Emblica officinalis Solution - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | Postgraduate Medical Institute, Lahore | 66 | 2026-09-17 | 2026-09-22 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars Oxymetazoline 0.05% nasal solution, Sodium Hypochlorite Solution - Pulp Disease, Dental, Pulp Therapy in Primary Molars | Not applicable | Not yet recruiting | Cairo University | 50 | 2026-08-01 | 2026-06-30 |
| Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid Standard Non-Surgical Periodontal Therapy, tandard Therapy + Sodium Hypochlorite/Amino Acid Gel, Standard Therapy + Sodium Hypochlorite/Amino Acid Gel + Cross-Linked Hyaluronic Acid - Periodontitis | Not applicable | Not yet recruiting | Marwan El Mobadder | 78 | 2026-03-11 | 2026-03-17 |
| Comparison of Sodium Hypochlorite Gel and Solution With and Without Nanoparticles for Postoperative Pain After Pulpotomy in Permanent Mandibular Molars Sodium Hypochlorite gel 2%, Sodium hypochlorite gel 2% with chitosan nano particles, Sodium hypochlorite solution 2% with chitosan nanoparticles - Vital Pulp Therapies, Pulpotomy | Not applicable | Active not recruiting | Future University in Egypt | 60 | 2026-03-01 | 2026-08-19 |
| Effect of Certain Denture Disinfectants on Surface Topography, Microhardness and Dimensional Stability of CAD/CAM Milled Polymethyl Methacrylate and Polyether Ether Ketone Denture Base Materials M0 group, M1 group : PMMA+ Sodium hypochlorite, M2 group: PMMA+ Chlorhexidine - Denture, CAD/CAM | Not applicable | Enrolling by invitation | Menoufia University | 88 | 2026-01-31 | 2026-06-29 |
| Evaluation Of Laser Versus Conventional Pulpotomies In Mature Molar Teeth With Irreversible Pulpitis Diode laser, Sodium Hypochlorite Solution - Irreversible Pulpitis (Toothache) | Not applicable | Recruiting | Rana Hegaz | 60 | 2025-11-07 | 2025-12-17 |
| Evaluation of the Effects of Different Irrigation Solutions and Activation Methods on Postoperative Pain and Quality of Life in Root Canal Treatment Irrigation with Sodium Hypochlorite and Conventional Syringe, Irrigation with Sodium Hypochlorite and EDDY, Procedure: Irrigation with Sodium Hypochlorite and Diode Laser - Irreversible Acute Pulpitis, Root Canal Treatment | Not applicable | Active not recruiting | Ankara Yildirim Beyazıt University | 90 | 2025-11-01 | 2025-11-21 |
| Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment Sodium Hypochlorite 1% Irrigation, Sodium Hypochlorite 2.5% Irrigation, Sodium Hypochlorite 5% Irrigation - Persistent Apical Periodontitis | Not applicable | Recruiting | KEZBAN MELTEM ÇOLAK | 60 | 2025-10-01 | 2026-03-06 |
| Clinical and Radiographic Evaluation of Ultrasonic Activated Irrigation Versus Non Activated Irrigation in Pulpectomy of Necrotic Primary Molars : A Randomized Clinical Trial Ultrasonic activated sodium hypochlorite, Ultrasonic acivated saline, Sodium Hypochlorite Solution - Pulpectomy Agents | Not applicable | Not yet recruiting | Cairo University | 100 | 2025-08-01 | 2025-06-17 |
| Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars Sodium hypochlorite, Moringa Oleifera Leaf Extract - Dental Caries, Pulp Necrosis | Not applicable | Not yet recruiting | Cairo University | 38 | 2025-07-20 | 2025-06-03 |
| Herbal Irrigation in Necrotic Primary Molars 10 % water extract of Boswellia Sacra, 1 % Sodium Hypochlorite, 0.9 % Normal Saline - Herbal Irrigation in Necrotic Primary Molars | Not applicable | Not yet recruiting | Cairo University | 30 | 2025-07-01 | 2025-05-22 |
| Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents - Apical Periodontitis, Dental Pulp Necrosis | Not applicable | Recruiting | ESRA DAĞCI | 90 | 2025-05-05 | 2025-07-04 |
| Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite - Pulp Necrosis, Apical Periodontitis | Not applicable | Enrolling by invitation | National and Kapodistrian University of Athens | 66 | 2025-04-01 | 2025-06-03 |
| Comparison of Effectiveness of Disinfectants Sodium Hypochlorite, Chlorhexidine - Root Canal Infection | Phase 1 | Completed | Armed Forces Institute of Dentistry, Pakistan | 124 | 2024-03-24 | 2025-02-06 |
| Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal Root canal tratment using mecchanical and chemical preparation., Sodium Hypochlorite., Hydrogen peroxide. - Apical Periodontitis, Root Canal Infection | Not applicable | Active not recruiting | National and Kapodistrian University of Athens | 44 | 2023-12-01 | 2025-05-11 |
| Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp Vachellia Nelotica, sodium hypochlorite - Necrotic Pulp, Post Operative Pain | Phase 4 | Unknown | Cairo University | 46 | 2023-11-01 | 2023-11-03 |
| Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection Waterlase Express™, BIOLASE®, Sodium Hypochlorite - Endodontic Disease, Root Canal Infection | Not applicable | Terminated | University of Pennsylvania | 56 | 2023-10-11 | 2025-10-09 |
| Effect of Epigallocatechin-3-Gallate Solution as a Root Canal Irrigant on Post-Operative Pain Intensity and Bacterial Load Reduction in Necrotic Tooth Epigallocatechin-3-gallate, sodium hypochlorite - Necrotic Pulp | Not applicable | Completed | Cairo University | 40 | 2023-10-01 | 2025-01-10 |
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Dental Pulp Necrosis (13) · Pain, Postoperative (10) · Periapical Periodontitis (8) · Dental Pulp Diseases (5) · Dermatitis, Atopic (5) · Staphylococcal Infections (4) · Dental Caries (3) · Abscess (2) · Eczema (2) · Furunculosis (2) · Periodontitis (2) · Radiodermatitis (2) · Staphylococcal Skin Infections (2) · Bacterial Infections (1) · Breast Neoplasms (1)
Cairo University (16) · Postgraduate Institute of Dental Sciences Rohtak (3) · University of Pennsylvania (3) · Federal University of Pelotas (2) · National and Kapodistrian University of Athens (2) · Stanford University (2) · University of Sao Paulo (2) · Washington University School of Medicine (2) · Altamash Institute of Dental Medicine (1) · Ankara Yildirim Beyazıt University (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Association of Paediatric and Preventive Dentists of Serbia (1) · Centers for Disease Control and Prevention (1) · Cukurova University (1)
Egypt (14) · United States (14) · Pakistan (5) · India (3) · Turkey (Türkiye) (3) · Brazil (2) · Greece (2) · China (1) · Ethiopia (1) · France (1) · Hungary (1) · Iraq (1) · Lebanon (1) · Philippines (1) · Saudi Arabia (1)
Amy Paller, MD (1) · Anshu Yadav (1) · Bekir Karabucak, DMD, MS (1) · Bekir Karabucak, DMD, MS. (1) · Bernard C. Camins, MD, MSCR (1) · Beth Beadle (1) · Bezatu M Alemu, M.Sc (1) · Dalia Abdallah (1) · Dalia Fayyad (1) · Donna Marie L. Sarrosa, MD, FPDS (1) · Fatih Cakici, DDS, PhD (1) · Flavia Teles, DDS,MS,DMSc (1) · Giorge Tzanetakis, Dr (PhD) (1)
PMID 14651280, PMID 21238793, PMID 3457698, PMID 11225528, PMID 11505791, PMID 14503827, PMID 14655819, PMID 15917679, PMID 16490989, PMID 16553931, PMID 17099299, PMID 18437843, PMID 18928835, PMID 19345793, PMID 19403473, PMID 1955657, PMID 19961451, PMID 20354090, PMID 2084204, PMID 21329812, PMID 21828967, PMID 21924201, PMID 22403423, PMID 22892736, PMID 22986783, PMID 23017003, PMID 23433693, PMID 24139274, PMID 24194899, PMID 24651335, PMID 25354086, PMID 25627883, PMID 25892512, PMID 25952354, PMID 26580306, PMID 27142579, PMID 27215810, PMID 28483164, PMID 29633177, PMID 30639191, PMID 30981431, PMID 3162597, PMID 31761015, PMID 32047895, PMID 32159775, PMID 32326426, PMID 32425001, PMID 32505069, PMID 32521007, PMID 32585261
P30CA124435 (1), R21AR062357 (1), R24HS022434 (1)