62 completed, 16 unknown, 8 recruiting, 7 active not recruiting. 102 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 102 | Completed 62, Unknown 16, Recruiting 8, Active not recruiting 7, Not yet recruiting 7, Enrolling by invitation 1, Terminated 1 |
Follow Apical Periodontitis: new trials by email Literature Review of Apical Periodontitis trials Research Report on Apical Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2027-07-01 | 2026-04-08 |
| Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment Photon-Induced Photoacoustic Streaming, Shock Wave Enhanced Emission Photoacoustic Streaming, Passive Ultrasonic Irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | Inonu University | 90 | 2026-11-01 | 2026-10-29 |
| Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5% - Pulp Necrosis, Apical Periodontitis | Not applicable | Recruiting | October 6 University | 60 | 2026-10-01 | 2026-10-27 |
| Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation sonically activated irrigation, laser activated irrigation, conventional needle irrigation - Apical Periodontitis, Post Operative Pain, Acute | Not applicable | Not yet recruiting | University Ghent | 183 | 2026-10-01 | 2026-10-29 |
| Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste - Apical Periodontitis, Post Endodontic Pain | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 50 | 2026-08-30 | 2026-08-13 |
| Biomarkers in Apical Periodontitis laser activation, PUI, CSI - Apical Periodontitis, Retreatment | Not applicable | Completed | Kırıkkale University | 66 | 2026-08-30 | 2026-10-21 |
| Effect of Different Apical Motion Algorithms on Postoperative Pain After Root Canal Treatment Root Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation - Apical Periodontitis, Postoperative Pain After Endodontic Treatment | Not applicable | Recruiting | Alanya Alaaddin Keykubat University | 120 | 2026-08-20 | 2026-10-27 |
| Postoperative Pain After OCT or EDTA Irrigation in Regenerative Endodontic Treatment Regenerative Endodontic Treatment Using Different Irrigation Solutions - Apical Periodontitis, Endodontic Disease | Not applicable | Completed | TC Erciyes University | 40 | 2026-04-10 | 2026-10-23 |
| Retreatment and Diabetes root canal retreatment - Apical Periodontitis | Not applicable | Completed | TC Erciyes University | 50 | 2026-01-01 | 2026-07-01 |
| Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis Calcium Hydroxide (Ca(OH)2) Intracanal Medication, Calcium Hydroxide + Iodoform (Metapex), Calcium Hydroxide + Betamethasone - Apical Periodontitis | Not applicable | Completed | Medipol University | 45 | 2026-01-01 | 2026-10-28 |
| In Vivo-Ex Vivo Evaluation of the Root ZX3 for Working-Length Determination Root ZX3 Electronic Apex Locator - Apical Periodontitis, Pulp Disease, Dental | Not applicable | Completed | Riyadh Elm University | 41 | 2025-10-19 | 2026-07-08 |
| To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis Full pulpotomy in adults ≥18 years with restorable mandibular first or second molars diagnosed with irreversible pulpitis, with or without apical periodontitis. - Apical Periodontitis | Not applicable | Not yet recruiting | Postgraduate Institute of Dental Sciences Rohtak | 128 | 2025-10-15 | 2025-09-18 |
| The Effect of Different Intracanal Medicaments on Periapical Lesion Healing Diclofenac sodium - Periapical Lesion Healing, Apical Periodontitis | Not applicable | Recruiting | Mustafa Kemal University | 60 | 2025-09-15 | 2026-10-07 |
| Effect of Different Methods of Cryotherapy Applications on Postoperative Pain and Substance P Level in Patients With Acute Irreversible Pulpitis With Apical Periodontitis: A Randomized Controlled Trial Extra-oral Cryotherapy, Intra-canal Cryotherapy, Combination (extra-oral and intra-canal) - Irreversible Pulpitis, Apical Periodontitis | Not applicable | Completed | Ahmad badrah | 40 | 2025-08-29 | 2026-10-29 |
| Effect of Integrated Apex Locator Motor Modes on Postoperative Pain in Endodontic Retreatment Electronic Apex Locator, Integrated Apex Locator Motor - Apical Periodontitis, Postoperative Pain | Not applicable | Completed | Recep Tayyip Erdogan University | 144 | 2025-08-13 | 2026-04-14 |
| Post-operative Pain After Different Irrigation and Disinfection Methods in Single-rooted Teeth EDDY sonic irrigation system, EndoActivator (EA) sonic irrigation system, 980-nm diode laser - Post Operative Pain, Apical Periodontitis | Not applicable | Completed | Biruni University | 80 | 2025-08-10 | 2026-01-12 |
| A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits single visit instrumentation, multiple visit instrumentation - Apical Periodontitis, Necrotic Pulps | Not applicable | Not yet recruiting | Marwa Hisham Mohamed Salah Eldin | 28 | 2025-08-01 | 2025-08-03 |
| Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers AH Plus and PAI 2-3, AH Plus and PAI 4, TotalFill BC Sealer and PAI 2-3 - Root Canal Obturation, Apical Periodontitis | Not applicable | Active not recruiting | Ankara Yildirim Beyazıt University | 64 | 2025-06-01 | 2025-12-29 |
| Apical Patency, Periapical Lesion Volume, and Postoperative Pain After Root Canal Treatment Apical Patency During Root Canal Treatment, Root Canal Treatment Without Apical Patency - Apical Periodontitis | Not applicable | Completed | Recep Tayyip Erdogan University | 113 | 2025-05-22 | 2026-08-24 |
| Effect of Apical Patency on Periapical Lesion Healing Apical Patency During Root Canal Treatment, Root Canal Treatment Without Apical Patency - Periapical Lesion, Apical Periodontitis | Not applicable | Active not recruiting | Recep Tayyip Erdogan University | 113 | 2025-05-22 | 2026-10-09 |
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Periapical Periodontitis (102) · Pain, Postoperative (26) · Dental Pulp Necrosis (14) · Pain (5) · Periapical Diseases (4) · Pulpitis (4) · Tooth, Nonvital (4) · Dental Pulp Diseases (3) · Diabetes Mellitus, Type 2 (3) · Diabetes Mellitus (2) · Radicular Cyst (2) · Asymptomatic Infections (1) · Bites and Stings (1) · Coronary Artery Disease (1) · Dental Caries (1)
Jaw Diseases (102) · Periodontal Diseases (102) · Periodontitis (102) · Stomatognathic Diseases (102) · Mouth Diseases (101) · Periapical Diseases (98) · Pathological Conditions, Signs and Symptoms (40) · Pathologic Processes (38) · Neurologic Manifestations (30) · Signs and Symptoms (30) · Pain (25) · Postoperative Complications (25) · Tooth Diseases (24) · Dental Pulp Diseases (20) · Necrosis (14)
Endodontics (4) · Sodium Hypochlorite (4) · Edetic Acid (3) · Therapeutic Irrigation (3) · Calcium Hydroxide (2) · Control Groups (2) · Lasers, Semiconductor (2) · Methods (2) · Sodium Chloride (2) · epoxy resin-based root canal sealer (2) · Alkalies (1) · Apicoectomy (1) · Betamethasone (1) · Biodent (1) · Chlorhexidine (1)
Postgraduate Institute of Dental Sciences Rohtak (15) · Cairo University (7) · Biruni University (3) · Isparta Military Hospital (3) · Medipol University (3) · Recep Tayyip Erdogan University (3) · TC Erciyes University (3) · Ain Shams University (2) · Dow University of Health Sciences (2) · Istanbul Medipol University Hospital (2) · Kahramanmaras Sutcu Imam University (2) · Marmara University (2) · Minia University (2) · Mustafa Kemal University (2) · National and Kapodistrian University of Athens (2)
Turkey (Türkiye) (42) · Egypt (10) · India (9) · United States (5) · Pakistan (4) · Belgium (2) · Greece (2) · Jordan (2) · Saudi Arabia (2) · Sweden (2) · Brazil (1) · Bulgaria (1) · Croatia (1) · Denmark (1) · Malaysia (1)
Aliye Kamalak (2) · Abdurrahman Aksoy, PhD (1) · Abier Fahad Alhekeir (1) · Aladdin Al Qudah, BDS, MSc, PhD (1) · Amatallah HN Al-Rawhani, Master (1) · Araib AT Tahir, BDS (1) · Bekir Karabucak, DMD, MS (1) · Brian Judd, DDS (1) · Camilla C Gomes Moura, PhD (1) · Can Wang, PhD (1)
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