42 completed, 6 withdrawn, 5 terminated, 4 unknown. 19 Phase 2, 14 Phase 4, 11 Not applicable, 9 Phase 3, 6 Phase 1.
Follow Tetracaine: new trials by email Literature Review of Tetracaine trials Research Report on Tetracaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic Pain Lidocaine (23%) + Tetracaine (7%), Placebo cream application - Neuropathic Chronic Pain | Phase 1 / Phase 2 | Not yet recruiting | Pontificia Universidad Catolica de Chile | 30 | 2026-09-20 | 2026-08-25 |
| The Impact of Intrapleural Block on Postoperative Pain Caused by Drainage Tubes After Thoracoscopic Surgery normal saline, Investigational drug 20 mL of 0.5% ropivacaine, 0.5% ropivacaine + 25 mg tetracaine, made up to a total volume of 20 mL - Postoperative Analgesia | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 300 | 2026-04-20 | 2026-03-16 |
| Evaluation of the Efficacy and Onset of Action of a Topical Anesthetic Marker Cutaneous marker (Transcutol P+ 20%, Tetracaine 7%, Lidocaine 23%, and dye q.s.), - Pain Management | Phase 2 | Not yet recruiting | Hexsel Dermatology Clinic | 20 | 2026-03-01 | 2025-12-10 |
| Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 1 drop of 0.5% tetracaine and 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 3 drops of a 0.8% tropicamide + 5% phenylephrine combination - Diabetes (DM), Retinopathy, Diabetic | Not applicable | Completed | Burapha University | 84 | 2024-11-04 | 2026-03-27 |
| Pain Management During Panretinal Photocoagulation for Diabetic Retinopathy: Safety and Efficacy of Peribulbar Anesthesia Peribulbar anesthesia with 0.5% bupivacaine and 2% lidocaine, Tetracaine 5% drops - Proliferative Diabetic Retinopathy | Phase 4 | Completed | Asociación para Evitar la Ceguera en México | 50 | 2023-07-06 | 2026-07-14 |
| Topical Lidocaine 23%/Tetracaine 7% Ointment for Post-Hemorrhoidectomy Analgesia: A Randomized Controlled Trial Lidocaine 23% / Tetracaine 7% topical ointment (compounded), Placebo ointment - Pain Management, Hemorrhoids Third Degree | Phase 4 | Completed | Pontificia Universidad Catolica de Chile | 74 | 2023-05-24 | 2026-07-07 |
| PK of Lidocaine/Tetracaine and PD Derived From a New Topical Formulation for Treatment of Neuropathic Pain. Lidocaine topical - Neuralgia, Neuropathic Pain | Completed | Pontificia Universidad Catolica de Chile | 20 | 2023-03-17 | 2025-07-31 | |
| Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection Tetracaine 5% drops, Phenol 90% concentration - Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss | Early Phase 1 | Unknown | Our Lady of the Lake Hospital | 80 | 2021-08-01 | 2023-10-31 |
| Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face 2.5 g of lidocaine 23% / tetracaine 7% ointment without occlusion, 7.5 g lidocaine 2.5%/ prilocaine 2.5% cream with occlusion - Anesthesia, Local, Photodamaged Skin | Phase 2 / Phase 3 | Completed | Mayo Clinic | 22 | 2021-01-08 | 2026-02-20 |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Withdrawn | Virginia Commonwealth University | 2020-09-01 | 2024-10-15 | |
| Topical Analgesia Before Inhalational Anaesthesia Topical analgesia (EMLA or AMETOP) - Anesthesia, Pediatric ALL | Completed | Nottingham University Hospitals NHS Trust | 500 | 2020-08-01 | 2021-07-13 | |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Withdrawn | Virginia Commonwealth University | 2020-08-01 | 2020-06-25 | |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Terminated | Virginia Commonwealth University | 3 | 2019-08-28 | 2020-11-19 |
| Comparison of 2 Application Techniques for LET Gel Used Prior to Simple Laceration Repair LET (lidocaine 4%; epinephrine 0.1%; tetracaine 0.5%) gel (1 application), LET (lidocaine 4%; epinephrine 0.1%; tetracaine 0.5%) gel (3 applications) - LET, Laceration of Skin | Phase 4 | Completed | Children's Hospital of Orange County | 48 | 2019-06-19 | 2020-09-02 |
| Ametop Compared to Ametop With Pain Ease Spray Pain Ease Cold Spray, Ametop - Analgesia, Topical Anesthetic | Not applicable | Unknown | University of British Columbia | 240 | 2018-11-20 | 2018-11-21 |
| Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment Tetracaine HCl and oxymetazoline HCl nasal spray - Endodontic Disease, Endodontic Inflammation | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2018-09-01 | 2018-11-16 | |
| : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic tetracaine HCl and oxymetazoline HCL, 2% Lidocaine with 1:100,000 epinephrine, 3% Mepivacaine with 1:100,000 epinephrine - Local Anesthetic Drug Adverse Reaction, Local Infiltration | Phase 4 | Unknown | Louisiana State University Health Sciences Center in New Orleans | 25 | 2018-01-03 | 2017-12-11 |
| Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P - No Disease State or Condition | Phase 2 | Completed | Cetylite Industries | 75 | 2017-06-15 | 2019-08-21 |
| Comparison of Two Application Techniques for LET Gel LET Lidocaine (4%), Epinephrine (0.1%), and Tetracaine (0.5%) topical gel - Lacerations, Pain, Procedural | Phase 4 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 48 | 2017-05-22 | 2021-02-18 |
| Decision Support for Intraoperative Low Blood Pressure Attending real-time decision support, In-room real-time decision support, Attending feedback emails - Hypotension | Not applicable | Completed | Vanderbilt University Medical Center | 22435 | 2017-01-05 | 2019-05-16 |
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Pain (12) · Agnosia (8) · Dental Caries (3) · Periapical Periodontitis (3) · Dental Pulp Diseases (2) · Macular Degeneration (2) · Acute Kidney Injury (1) · Behavior (1) · Carpal Tunnel Syndrome (1) · Cataract (1) · Corneal Injuries (1) · Diabetes Mellitus (1) · Diabetic Retinopathy (1) · Dilatation, Pathologic (1) · Drug-Related Side Effects and Adverse Reactions (1)
St. Renatus, LLC (11) · Pontificia Universidad Catolica de Chile (3) · Virginia Commonwealth University (3) · ZARS Pharma Inc. (3) · Cetylite Industries (2) · Galderma R&D (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · University of British Columbia (2) · Asociación para Evitar la Ceguera en México (1) · Boston Children's Hospital (1) · Burapha University (1) · Children's Hospital of Orange County (1) · Chinese PLA General Hospital (1) · Fraser Health (1) · Futura Medical Developments Ltd. (1)
United States (32) · Canada (8) · China (3) · Chile (2) · France (1) · Mexico (1) · Thailand (1) · United Kingdom (1)
Parthasarathy Madurantakam, DDS, PhD (3) · Paul A. Moore, DMD/PhD/MPH (3) · Albert Wolkerstorfer, MD, PhD (1) · Angela YJ Tan, MMed (1) · Anna Taddio, PhD (1) · Anthony R Godfrey, Pharm.D. (1) · Asma Khan, DDS (1) · Brandi D Newby, BScPharm (1) · Christina Sletten, DDS (1) · Elika Hoss (1) · Elliot V Hersh, DMD, MS, PhD (1) · Elliot V Hersh, DMD, Ph.D. (1) · Feng Lin, MD (1) · Guizhi Du, Doctor (1)
PMID 16478902, PMID 18343253, PMID 19151049, PMID 20975464, PMID 22943969, PMID 23061994, PMID 23690356, PMID 26531052, PMID 26892312, PMID 26988368, PMID 28943117, PMID 30660443, PMID 32126990, PMID 35100752, PMID 35475300, PMID 35622535