36 completed, 16 unknown, 13 recruiting, 7 terminated. 59 Not applicable, 6 Phase 2, 6 Phase 3, 6 Phase 4, 4 Phase 1.
Follow Therapeutic Irrigation: new trials by email Literature Review of Therapeutic Irrigation trials Research Report on Therapeutic Irrigation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL) Exercise Therapy, Extracorporeal Shockwave Therapy, Ultrasound-Guided Percutaneous Irrigation - Rotator Cuff Tendinosis, Rotator Cuff Injuries | Not applicable | Suspended | University of Valencia | 116 | 2028-01-01 | 2026-06-26 |
| Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study Irrigation with PVI, Usual care - Acute, Perforated Appendicitis | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 1750 | 2027-03-01 | 2025-02-10 |
| Impact Evaluation of Accelerating Climate-Resilient Water, Sanitation and Hygiene Services for Schools and Healthcare Facilities in Karamoja Climate-resilient school WASH infrastructure package, WASH and menstrual health capacity building and social and behaviour change package - Diarrhea, Respiratory Tract Infections (RTI) | Not applicable | Recruiting | Elijah Kipchumba | 16380 | 2026-10-19 | 2026-09-16 |
| Uterine Lavage to Detect Ovarian Cancer Risk Uterine Lavage, Archive Sample, Survey Administration - BRCA Hereditary Ovarian Carcinoma, Fallopian Tube High Grade Serous Adenocarcinoma | Not applicable | Recruiting | University of Washington | 75 | 2026-09-03 | 2026-09-14 |
| Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial Arthrocentesis, Botulinum Toxin-A - Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome | Not applicable | Not yet recruiting | Mudher MB Alsunbuli | 66 | 2026-08-15 | 2026-07-30 |
| Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ Arthroscopic lysis and lavage, arthroscopic lysis and lavage with intra-articular injection of hyaluronic acid - TMJ Disc Disorder, Temporomandibular Joint Disc Displacement, Without Reduction | Not applicable | Not yet recruiting | Cairo University | 52 | 2026-05-01 | 2026-05-29 |
| Effect of Mandibular Drilling Speed on Implant Stability and Osteogenic Potential: A Randomized Clinical Trial Implant osteotomy using biological drilling at 50 rpm without irrigation., Implant osteotomy using biological drilling at 150 rpm without irrigation., Implant osteotomy using biological drilling at 300 rpm without irrigation. - Edentulism, Tooth Loss | Not applicable | Not yet recruiting | Cairo University | 36 | 2026-03-15 | 2026-03-16 |
| Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease Irrisept (0.05% chlorhexidine gluconate), Normal Saline - Pilonidal Disease | Not applicable | Recruiting | Yosef Nasseri, MD | 60 | 2026-02-17 | 2026-03-27 |
| The Impact of Saline Temperature and Local Anesthetic Adjuvants on Postoperative Shoulder Pain and Inflammatory Marker Levels Following Laparoscopic Cholecystectomy Room-temperature saline (25-30 ml/kg ) irrigation without local anesthetic., Room-temperature saline (25-30 ml/kg l) with local anesthetic ( 0.25% bupivacaine according to body weight)., Warm saline (37°C, 25-30 ml/kg ) irrigation without local anesthetic. - Shoulder Pain , Laparoscopic Cholecystectomy | Not applicable | Enrolling by invitation | Alexandria University | 216 | 2026-02-01 | 2026-03-17 |
| Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis Final irrigation with 2.5% NaOCl and 17% EDTA, Final irrigation with 2.5% NaOCl and 9% HEBP, Irrigation with 2.5% NaOCl-9% HEBP during both preparation and final irrigation - Chronic Apical Periodontitis | Not applicable | Active not recruiting | Mustafa Kemal University | 63 | 2025-12-01 | 2026-01-23 |
| Evaluation of the Effects of Different Irrigation Solutions and Activation Methods on Postoperative Pain and Quality of Life in Root Canal Treatment Irrigation with Sodium Hypochlorite and Conventional Syringe, Irrigation with Sodium Hypochlorite and EDDY, Procedure: Irrigation with Sodium Hypochlorite and Diode Laser - Irreversible Acute Pulpitis, Root Canal Treatment | Not applicable | Active not recruiting | Ankara Yildirim Beyazıt University | 90 | 2025-11-01 | 2025-11-21 |
| Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment Sodium Hypochlorite 1% Irrigation, Sodium Hypochlorite 2.5% Irrigation, Sodium Hypochlorite 5% Irrigation - Persistent Apical Periodontitis | Not applicable | Recruiting | KEZBAN MELTEM ÇOLAK | 60 | 2025-10-01 | 2026-03-06 |
| Assessment of Ozone Therapy for Management of Post-Extraction Localized Alveolar Osteitis Topical Ozone Therapy, Irrigation with saline - Alveolar Osteitis | Not applicable | Not yet recruiting | Menoufia University | 40 | 2025-08-01 | 2025-08-06 |
| Efficacy Testing of a Multi-Level Family Planning Intervention Family Planning Intervention, Water, Sanitation, and Hygiene (WASH) Intervention - Unintended Pregnancy, Family Planning | Phase 2 / Phase 3 | Recruiting | Boston College | 1464 | 2025-06-12 | 2026-03-23 |
| The Effect of Different Irrigation Methods Used During Endodontic Treatment on Postoperative Pain in Teeth With Periapical Lesions Irrigation - Mandibular Premolars and Canines With Asymptomatic Apical Periodontitis | Not applicable | Completed | Akdeniz University | 88 | 2025-06-01 | 2026-02-13 |
| TMJ Arthroscopy Compared to Arthrocentesis in Disc Displacement Without Reduction Arthroscopic lysis and lavage, Arthrocentesis/Saline - Temporomandibular Joint Disc Displacement, Temporomandibular Joint Disc Displacement, Without Reduction | Not applicable | Recruiting | Karolinska Institutet | 100 | 2025-04-01 | 2026-08-06 |
| TMJ Arthroscopic Lysis and Lavage Compared to Operative Arthroscopy in Disc Displacement With Reduction. Arthroscopic lysis and lavage, Operative arthroscopy - Temporomandibular Joint Disc Displacement, With Reduction, Temporomandibular Disorders (TMD) | Not applicable | Recruiting | Karolinska Institutet | 96 | 2025-04-01 | 2026-08-06 |
| Evaluation of REACTS-IN, an Intervention to Improve Nutrition, Hygiene, and Sexual and Reproductive Health Services Education intervention on nutrition, gender equity, WASH, sexual and reproductive health rights, school-based iron-folic acid supplement program, Health service training on equitable access to nutrition, health, and sexual and reproductive services - Stunting, Gender Equality | Not applicable | Recruiting | McGill University | 13500 | 2024-09-01 | 2026-04-29 |
| Anastomotic Leakage in Right Colectomy suturing of leak, lavage, drainage, Formation of a new anasthomosis, Fecal diversion - Anastomotic Leak | Unknown | Barmherzige Brüder Vienna | 3446 | 2024-08-12 | 2024-08-14 | |
| Effect of Smoking on Macrophage-related Chemokines Before and After Non-surgical Treatment of Initial Peri-implantitis Debridement of implant surface with titanium curettes and irrigation with sterile saline solution - Peri-implantitis | Not applicable | Completed | Buse Naz BÜYÜKAKÇALI ALTAY | 63 | 2024-04-28 | 2025-02-05 |
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Pain, Postoperative (5) · Appendicitis (4) · Periapical Periodontitis (4) · Temporomandibular Joint Disorders (4) · Dental Pulp Necrosis (3) · Growth Disorders (3) · Infections (3) · Surgical Wound Infection (3) · Breast Neoplasms (2) · Diabetic Foot (2) · Ovarian Neoplasms (2) · Peri-Implantitis (2) · Rotator Cuff Injuries (2) · Rotator Cuff Tear Arthropathy (2) · Shoulder Pain (2)
Cairo University (5) · Akdeniz University (2) · Karolinska Institutet (2) · The University of Texas Health Science Center, Houston (2) · University of California, San Francisco (2) · University of Nove de Julho (2) · University of Washington (2) · Alexandria University (1) · Ankara Yildirim Beyazıt University (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Barmherzige Brüder Vienna (1) · Betsie van Gaal (1) · Boston College (1) · British University In Egypt (1)
United States (26) · Egypt (9) · Turkey (Türkiye) (9) · Brazil (3) · Canada (3) · France (3) · Sweden (3) · Austria (2) · Bangladesh (2) · China (2) · Germany (2) · Spain (2) · Uganda (2) · Belgium (1) · Ethiopia (1)
Lawrence A Lavery, DPM (2) · Mattias Ulmner, DDS, PhD (2) · Adam Adler, MD (1) · Ahmad M Shaddad, MD (1) · Ali A Ali, MSc (1) · Aliae A Hussien, MD (1) · Amani Khairy, Professor (1) · Amin R Javer, MD, FRCSC (1) · AnaMaria Garza, MD (1) · Andrew Kaiser-Tedesco, MSc (1) · Annelies Wilder-Smith, MD (1) · B.Todd Schaeffer, MD (1) · Barbara Norquist, MD (1) · Barbara S. Norquist (1)
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2023 (2), R01HD060338 (1), R01HD113806 (1), U10EY023939 (1)