3 completed, 2 not yet recruiting, 2 withdrawn, 1 active not recruiting. 10 Phase 2, 4 Phase 3, 1 Phase 1.
Follow Apical Periodontitis: new trials by email Literature Review of Apical Periodontitis trials Research Report on Apical Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC) - Apical Periodontitis | Phase 2 | Active not recruiting | Alexandria University | 40 | 2025-11-15 | 2025-12-30 |
| To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis Calcium Hydroxide Intracanal medication, triple antibiotic paste (TAP) - Apical Periodontitis, Irreversible Pulpitis with Apical Periodontitis | Phase 2 / Phase 3 | Unknown | Komal Ashraf Khan | 180 | 2025-05-01 | 2025-02-12 |
| The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study Stem Cell Product, Bleeding and clots - Apical Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | TC Erciyes University | 45 | 2025-01-01 | 2025-01-08 |
| Effect of Use of Calcium Hydroxide and Metformin Intracanal Medicament After NSRCT Metformin - Apical Periodontitis | Phase 2 / Phase 3 | Completed | Postgraduate Institute of Dental Sciences Rohtak | 120 | 2023-08-01 | 2025-05-28 |
| "Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial" Conventional group, Dual laser group, Combined group - Pulp Necroses, Apical Periodontitis | Phase 2 | Completed | Future University in Egypt | 45 | 2022-01-01 | 2026-06-30 |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Withdrawn | Virginia Commonwealth University | 2020-09-01 | 2024-10-15 | |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Withdrawn | Virginia Commonwealth University | 2020-08-01 | 2020-06-25 | |
| Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis Allogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis - Pulp Necroses, Apical Periodontitis | Phase 2 / Phase 3 | Completed | Universidad Central de Venezuela | 5 | 2019-11-27 | 2020-09-16 |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Terminated | Virginia Commonwealth University | 3 | 2019-08-28 | 2020-11-19 |
Periapical Periodontitis (10) · Dental Caries (3) · Dental Pulp Necrosis (2) · Pain, Postoperative (2) · Dental Pulp Diseases (1)
Jaw Diseases (10) · Mouth Diseases (10) · Periapical Diseases (10) · Periodontal Diseases (10) · Periodontitis (10) · Stomatognathic Diseases (10) · Tooth Diseases (5) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Tooth Demineralization (3) · Necrosis (2) · Neurologic Manifestations (2) · Pain (2) · Postoperative Complications (2) · Signs and Symptoms (2)
Carticaine (3) · Oxymetazoline (3) · Tetracaine (3) · Acetylcysteine (1) · Calcium Hydroxide (1) · Metformin (1)
Virginia Commonwealth University (3) · Alexandria University (1) · Future University in Egypt (1) · Komal Ashraf Khan (1) · Mohamed Ashraf Abdeen (1) · Postgraduate Institute of Dental Sciences Rohtak (1) · TC Erciyes University (1) · Universidad Central de Venezuela (1)
Egypt (3) · India (1) · Pakistan (1) · Turkey (Türkiye) (1) · United States (1) · Venezuela (1)
Parthasarathy Madurantakam, DDS, PhD (3) · Dr. Sanjay Tewari, MDS (1)