Necrosis: Clinical Trials

1897 completed, 846 unknown, 457 recruiting, 240 terminated. 1227 Not applicable, 421 Phase 4, 389 Phase 2, 384 Phase 3, 134 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1227	Completed 551, Unknown 255, Recruiting 164, Not yet recruiting 80, Terminated 70, Active not recruiting 58, Withdrawn 29, Enrolling by invitation 16, Suspended 4
Phase 4	421	Completed 221, Unknown 94, Recruiting 36, Terminated 34, Not yet recruiting 15, Withdrawn 14, Active not recruiting 7
Phase 2	389	Completed 195, Unknown 78, Terminated 41, Recruiting 28, Withdrawn 22, Not yet recruiting 12, Active not recruiting 9, Suspended 3, Enrolling by invitation 1
Phase 3	384	Completed 213, Unknown 70, Terminated 40, Recruiting 32, Not yet recruiting 12, Withdrawn 9, Active not recruiting 7, Suspended 1
Phase 1	134	Completed 72, Unknown 26, Terminated 11, Recruiting 7, Withdrawn 7, Suspended 5, Not yet recruiting 4, Active not recruiting 2
Early Phase 1	26	Completed 9, Unknown 7, Recruiting 5, Not yet recruiting 4, Terminated 1

Follow this condition Literature Review of Necrosis trials Research Report on Necrosis

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent Teeth Visual-tactile caries examination, Visual-tactile caries examination and bilateral bitewing radiography - Dental Caries, Teeth Loss	Not applicable	Not yet recruiting	Jukka Leinonen	250	2027-03-01	2026-10-20
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection	Early Phase 1	Not yet recruiting	Oman Dental College	30	2027-01-19	2026-09-22
AI-based Decision Support in Acute Chest Pain AIDE-CP available - Myocardial Infarction, Chest Pain	Not applicable	Not yet recruiting	Region Skane	4500	2027-01-18	2026-10-07
Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste - Dental Pulp Necrosis, Periapical Diseases	Not applicable	Not yet recruiting	Cairo University	50	2027-01-01	2026-08-19
Norwegian Danish Spontaneous Coronary Artery Dissection Exercise Study High intensity interval training (HIIT) - Spontaneous Coronary Artery Dissection, Myocardial Infarction (MI)	Not applicable	Enrolling by invitation	Oslo University Hospital	120	2027-01-01	2026-08-25
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)	Not applicable	Recruiting	Johns Hopkins University	5	2027-01-01	2026-10-09
French Observatory on the Management of Cardiogenic Shock 2 Cardiogenic Shock		Not yet recruiting	French Cardiology Society	1000	2027-01-01	2026-10-09
A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI) Coronary angiogram with coronary reactivity testing (CRT) - Myocardial Infarction, Coronary Microvascular Disease		Not yet recruiting	Mayo Clinic	52	2027-01-01	2026-08-31
The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), Aspirin Tablet - Cerebral Infarction	Phase 1	Suspended	Sclnow Biotechnology Co., Ltd.	40	2026-12-31	2026-04-23
Human Umbilical Cord Mesenchymal Stem Cell Therapy (19#iSCLife®-CI) for Cerebral Infarction Patients in Convalescent Period. Allogeneic umbilical cord mesenchymal stem cell, Aspirin Enteric-coated Tablets & Atorvastatin Calcium - Cerebral Infarction	Phase 1 / Phase 2	Suspended	Sclnow Biotechnology Co., Ltd.	40	2026-12-31	2026-04-23
The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression - Osteonecrosis of Femoral Head	Phase 1 / Phase 2	Suspended	Sclnow Biotechnology Co., Ltd.	30	2026-12-31	2026-04-23
Germany on Target Registry No study-assigned intervention - Myocardial Infarction (MI), Dyslipidemias		Not yet recruiting	Deutsche Gesellschaft für Lipidologie e. V. (DGFL) - Lipid-Liga	10000	2026-12-01	2026-09-28
Hong Kong Cardiogenic Shock Initiative Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction		Not yet recruiting	Prince of Wales Hospital, Shatin, Hong Kong	320	2026-12-01	2026-09-16
Clinical Evidence With Biomarker Confirmation for PPMI in PCI Clinical Trials Study Biomarker testing - Peri-procedural Myocardial Infarction, Heart Failure Hospitalization		Not yet recruiting	Baim Institute for Clinical Research	1000	2026-12-01	2026-09-30
Necrosectomy With Cryotechnology for Accelerated Removal Cryotechnology Necrosectomy Procedure - Pancreatic Necrosis, Acute Pancreatitis	Not applicable	Recruiting	Christopher C. Thompson, MD, MSc	20	2026-12-01	2026-06-25
DEXA Bone Density Analysis of the CoreHip® Prosthesis System Primary hip replacement with cementless stem - Primary Osteoarthritis, Cartilage Degeneration	Not applicable	Not yet recruiting	Aesculap AG	40	2026-12-01	2026-10-16
Effect of HBOT on Femoral Head Avascular Necrosis (AVN) Hyperbaric Oxygen Therapy - Osteonecrosis, Avascular Necrosis	Not applicable	Not yet recruiting	Yale University	400	2026-12-01	2026-07-01
Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis	Phase 4	Not yet recruiting	Jay C. Buckey Jr.	100	2026-11-01	2026-09-09
Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH) Decompressive craniectomy - Aneurysmal Subarachnoid Hemorrhage		Not yet recruiting	University Hospital, Essen	10000	2026-11-01	2026-10-14
DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma Combat Related Symptoms, Combat Trauma		Not yet recruiting	Ukrainian Society of Regional Anesthesia and Pain Therapy	500	2026-10-23	2026-07-16

Showing 20 of 3944. Sign in to see all of them.

Narrower conditions

Myocardial Infarction (1960)  ·  ST Elevation Myocardial Infarction (825)  ·  Stroke (406)  ·  Coronary Artery Disease (385)  ·  Acute Coronary Syndrome (343)  ·  Cardiovascular Diseases (336)  ·  Shock, Cardiogenic (289)  ·  Non-ST Elevated Myocardial Infarction (283)  ·  Osteonecrosis (258)  ·  Heart Failure (242)  ·  Myocardial Ischemia (212)  ·  Cerebral Infarction (206)  ·  Heart Diseases (190)  ·  Coronary Disease (181)  ·  Angina, Unstable (178)

Broader conditions

Pathological Conditions, Signs and Symptoms (3944)  ·  Pathologic Processes (3932)  ·  Vascular Diseases (3349)  ·  Infarction (3343)  ·  Ischemia (3331)  ·  Cardiovascular Diseases (3078)  ·  Heart Diseases (2830)  ·  Myocardial Ischemia (2791)  ·  Myocardial Infarction (1036)  ·  Nervous System Diseases (677)  ·  Central Nervous System Diseases (653)  ·  Brain Diseases (641)  ·  Cerebrovascular Disorders (595)  ·  Signs and Symptoms (498)

Interventions

Clopidogrel (82)  ·  Aspirin (78)  ·  Ticagrelor (75)  ·  Percutaneous Coronary Intervention (73)  ·  Standard of Care (42)  ·  Prasugrel Hydrochloride (33)  ·  Atorvastatin (32)  ·  Sodium Chloride (31)  ·  Saline Solution (30)  ·  Heparin (27)  ·  Abciximab (22)  ·  Arthroplasty, Replacement, Hip (22)  ·  Rivaroxaban (22)  ·  Blood Specimen Collection (20)  ·  Colchicine (20)

Sponsors

National Heart, Lung, and Blood Institute (NHLBI) (64)  ·  Zimmer Biomet (49)  ·  Assiut University (48)  ·  Cairo University (48)  ·  Assistance Publique - Hôpitaux de Paris (41)  ·  Mayo Clinic (29)  ·  University College, London (24)  ·  Central Hospital, Nancy, France (23)  ·  Karolinska Institutet (22)  ·  University of Edinburgh (22)  ·  Beijing Anzhen Hospital (21)  ·  Brigham and Women's Hospital (19)  ·  Copenhagen University Hospital, Rigshospitalet (19)  ·  AstraZeneca (18)  ·  Samsung Medical Center (18)

Countries

United States (739)  ·  China (397)  ·  France (320)  ·  Germany (275)  ·  United Kingdom (267)  ·  Canada (245)  ·  Italy (240)  ·  Spain (194)  ·  Netherlands (182)  ·  South Korea (158)  ·  Denmark (145)  ·  Poland (126)  ·  Switzerland (119)  ·  Sweden (116)  ·  Belgium (106)

Top investigators

Harry Hemingway, FRCP (11)  ·  Holger Thiele, MD (9)  ·  Hassan Achakri (8)  ·  Hillary Overholser (7)  ·  Axel Bauer, MD (6)  ·  David Antoniucci, MD (6)  ·  Paola Vivoda (6)  ·  Adnan Kastrati, MD (5)  ·  Emilie Rohmer (5)  ·  Georg Schmidt, MD (5)  ·  Petra Barthel, MD (5)  ·  Antonio Colombo, MD (4)  ·  Emily Herrett, MSc (4)

Results publications

PMID 35224730, PMID 34932836, PMID 41114449, PMID 28886621, PMID 35866376, PMID 36526898, PMID 30538057, PMID 31242362, PMID 36398903, PMID 37131096, PMID 12939209, PMID 15673543, PMID 15778204, PMID 22163120, PMID 22995877, PMID 25593120, PMID 26347918, PMID 26794722, PMID 28286967, PMID 29386200, PMID 30354592, PMID 30586701, PMID 31733140, PMID 32905623, PMID 36303402, PMID 38682335, PMID 40014670, PMID 10460813, PMID 15956631, PMID 17090774, PMID 17387132, PMID 17964349, PMID 17982163, PMID 18036459, PMID 19118718, PMID 19264239, PMID 19717846, PMID 19915221, PMID 19923168, PMID 20189026, PMID 20348438, PMID 20359842, PMID 20736446, PMID 20929341, PMID 21079055, PMID 21422390, PMID 21492763, PMID 21709062, PMID 21899409, PMID 22064593

NIH funding

2018 (11), 2019 (9), 2016 (8), 2009 (5), 2023 (5), 2025 (5), 2014 (4), 2015 (4), 2017 (3), 2005 (2), K23HL148310 (2), U01DC017844 (2), 1DP2DC021055 (1), 1RC2HL101458-01 (1), 1RF1AG074608-01 (1)