1909 completed, 843 unknown, 471 recruiting, 240 terminated. 1238 Not applicable, 423 Phase 4, 390 Phase 2, 384 Phase 3, 134 Phase 1.
Follow Necrosis: new trials by email Literature Review of Necrosis trials Research Report on Necrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hemodynamic Evaluation of Left Atrial Pressure in Relationship to Pulmonary Capillary Wedge Pressure in Cardio Thoracic Patients Cardiogenic Shock, Pulmonary Edema Cardiac Cause | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 136 | 2028-09-01 | 2026-11-04 | |
| The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent Teeth Visual-tactile caries examination, Visual-tactile caries examination and bilateral bitewing radiography - Dental Caries, Teeth Loss | Not applicable | Not yet recruiting | Jukka Leinonen | 250 | 2027-03-01 | 2026-10-20 |
| Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation tVNS session on the left earlobe, tVNS "SHAM" session the conchae aurea of the left ear - Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA) | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Saint Etienne | 64 | 2027-01-31 | 2026-10-23 |
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| AI-based Decision Support in Acute Chest Pain AIDE-CP available - Myocardial Infarction, Chest Pain | Not applicable | Not yet recruiting | Region Skane | 4500 | 2027-01-18 | 2026-10-07 |
| Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste - Dental Pulp Necrosis, Periapical Diseases | Not applicable | Not yet recruiting | Cairo University | 50 | 2027-01-01 | 2026-08-19 |
| Norwegian Danish Spontaneous Coronary Artery Dissection Exercise Study High intensity interval training (HIIT) - Spontaneous Coronary Artery Dissection, Myocardial Infarction (MI) | Not applicable | Enrolling by invitation | Oslo University Hospital | 120 | 2027-01-01 | 2026-08-25 |
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| French Observatory on the Management of Cardiogenic Shock 2 Cardiogenic Shock | Not yet recruiting | French Cardiology Society | 1000 | 2027-01-01 | 2026-10-09 | |
| A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI) Coronary angiogram with coronary reactivity testing (CRT) - Myocardial Infarction, Coronary Microvascular Disease | Not yet recruiting | Mayo Clinic | 52 | 2027-01-01 | 2026-08-31 | |
| PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth PRP-Assisted Regenerative Endodontic Treatment, Conventional Root Canal Treatment - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | TC Erciyes University | 10 | 2027-01-01 | 2026-11-05 |
| Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI Empagliflozin (SGLT2i), dapagliflozin, Standard medical treatment - No Reflow Phenomenon, Reperfusion Injuries, Myocardial | Phase 2 | Not yet recruiting | Al-Azhar University | 100 | 2027-01-01 | 2026-10-27 |
| Determination of Specificity and Sensitivity in Detecting Myocardial Infarction Using the EDE CARDIO BIO-MAP Machine Myocardial Infarction | Not yet recruiting | Weill Cornell Medical College in Qatar | 200 | 2027-01-01 | 2026-11-09 | |
| The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), Aspirin Tablet - Cerebral Infarction | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| Human Umbilical Cord Mesenchymal Stem Cell Therapy (19#iSCLife®-CI) for Cerebral Infarction Patients in Convalescent Period. Allogeneic umbilical cord mesenchymal stem cell, Aspirin Enteric-coated Tablets & Atorvastatin Calcium - Cerebral Infarction | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression - Osteonecrosis of Femoral Head | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 30 | 2026-12-31 | 2026-04-23 |
| Germany on Target Registry No study-assigned intervention - Myocardial Infarction (MI), Dyslipidemias | Not yet recruiting | Deutsche Gesellschaft für Lipidologie e. V. (DGFL) - Lipid-Liga | 10000 | 2026-12-01 | 2026-09-28 | |
| Hong Kong Cardiogenic Shock Initiative Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction | Not yet recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 320 | 2026-12-01 | 2026-09-16 | |
| Clinical Evidence With Biomarker Confirmation for PPMI in PCI Clinical Trials Study Biomarker testing - Peri-procedural Myocardial Infarction, Heart Failure Hospitalization | Not yet recruiting | Baim Institute for Clinical Research | 1000 | 2026-12-01 | 2026-09-30 | |
| Necrosectomy With Cryotechnology for Accelerated Removal Cryotechnology Necrosectomy Procedure - Pancreatic Necrosis, Acute Pancreatitis | Not applicable | Recruiting | Christopher C. Thompson, MD, MSc | 20 | 2026-12-01 | 2026-06-25 |
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Myocardial Infarction (1965) · ST Elevation Myocardial Infarction (829) · Stroke (408) · Coronary Artery Disease (387) · Acute Coronary Syndrome (343) · Cardiovascular Diseases (336) · Shock, Cardiogenic (289) · Non-ST Elevated Myocardial Infarction (283) · Osteonecrosis (258) · Heart Failure (243) · Myocardial Ischemia (213) · Cerebral Infarction (206) · Heart Diseases (190) · Coronary Disease (181) · Angina, Unstable (178)
Pathological Conditions, Signs and Symptoms (3962) · Pathologic Processes (3950) · Vascular Diseases (3360) · Infarction (3353) · Ischemia (3342) · Cardiovascular Diseases (3089) · Heart Diseases (2839) · Myocardial Ischemia (2799) · Myocardial Infarction (1039) · Nervous System Diseases (680) · Central Nervous System Diseases (656) · Brain Diseases (644) · Cerebrovascular Disorders (597) · Signs and Symptoms (503)
Clopidogrel (82) · Aspirin (79) · Ticagrelor (75) · Percutaneous Coronary Intervention (73) · Standard of Care (42) · Prasugrel Hydrochloride (33) · Atorvastatin (32) · Sodium Chloride (31) · Saline Solution (30) · Heparin (27) · Rivaroxaban (23) · Abciximab (22) · Arthroplasty, Replacement, Hip (22) · Blood Specimen Collection (20) · Colchicine (20)
National Heart, Lung, and Blood Institute (NHLBI) (64) · Assiut University (49) · Zimmer Biomet (49) · Cairo University (48) · Assistance Publique - Hôpitaux de Paris (41) · Mayo Clinic (29) · University College, London (24) · Central Hospital, Nancy, France (23) · Karolinska Institutet (22) · University of Edinburgh (22) · Beijing Anzhen Hospital (21) · Brigham and Women's Hospital (19) · Copenhagen University Hospital, Rigshospitalet (19) · AstraZeneca (18) · Samsung Medical Center (18)
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PMID 35224730, PMID 34932836, PMID 41114449, PMID 28886621, PMID 35866376, PMID 36526898, PMID 30538057, PMID 31242362, PMID 36398903, PMID 37131096, PMID 12939209, PMID 15673543, PMID 15778204, PMID 22163120, PMID 22995877, PMID 25593120, PMID 26347918, PMID 26794722, PMID 28286967, PMID 29386200, PMID 30354592, PMID 30586701, PMID 31733140, PMID 32905623, PMID 36303402, PMID 38682335, PMID 40014670, PMID 10460813, PMID 15956631, PMID 17090774, PMID 17387132, PMID 17964349, PMID 17982163, PMID 18036459, PMID 19118718, PMID 19264239, PMID 19717846, PMID 19915221, PMID 19923168, PMID 20189026, PMID 20348438, PMID 20359842, PMID 20736446, PMID 20929341, PMID 21079055, PMID 21422390, PMID 21492763, PMID 21709062, PMID 21899409, PMID 22064593
2018 (11), 2019 (9), 2016 (8), 2009 (5), 2023 (5), 2025 (5), 2014 (4), 2015 (4), 2017 (3), 2005 (2), K23HL148310 (2), U01DC017844 (2), 1DP2DC021055 (1), 1RC2HL101458-01 (1), 1RF1AG074608-01 (1)