64 completed, 16 unknown, 11 recruiting, 8 not yet recruiting. 51 Not applicable, 15 Phase 4, 9 Phase 2, 8 Phase 3, 2 Early Phase 1.
Follow Post-Dural Puncture Headache: new trials by email Literature Review of Post-Dural Puncture Headache trials Research Report on Post-Dural Puncture Headache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Spinal, Epidural, and Dural Puncture Epidural Anesthesia for Cesarean Delivery: Hemodynamics and Block Quality Spinal Anesthesia, Epidural Anesthesia, Dural Puncture Epidural Anesthesia - Hypotension After Neuraxial Anesthesia, Cesarean Section | Not applicable | Not yet recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 120 | 2026-12-01 | 2026-10-20 |
| Effect of Intravenous Oxytocin on Post Dural Puncture Headache After Caesarean Sections oxytocin, Normal Saline - Post Dural Puncture Headache | Phase 4 | Not yet recruiting | Assiut University | 100 | 2026-09-01 | 2026-10-02 |
| Predictive Value of ONSD and NIRS for PDPH Post-Dural Puncture Headache, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use | Recruiting | Ordu University | 44 | 2026-06-19 | 2026-07-27 | |
| Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach Spinal anesthesia using median approach (midline), Spinal anesthesia using paramedian approach - Post-Dural Puncture Headache, Headache After Spinal Puncture | Not applicable | Not yet recruiting | Mayo Hospital Lahore | 142 | 2026-05-01 | 2026-02-27 |
| Ultrasound-assisted vs Palpation-guided Lumbar Punctures Ultrasound-Assisted Lumbar Puncture, Standard Palpation-Guided Lumbar Puncture - Lumbar Puncture | Not applicable | Enrolling by invitation | The Cooper Health System | 132 | 2026-04-25 | 2026-09-17 |
| The Effect of Magnesium on Post-spinal Headaches Magnesium - Post-spinal Headache | Active not recruiting | Haseki Training and Research Hospital | 300 | 2026-04-01 | 2026-07-07 | |
| Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients Optic Nerve Sheath Diameter Measurement - Post Dural Puncture Headache | Not yet recruiting | Kocaeli University | 220 | 2026-03-20 | 2026-03-27 | |
| Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h) - Cesarean Section, Postoperative Nausea and Vomiting (PONV) | Not applicable | Recruiting | Nigde Omer Halisdemir University | 160 | 2026-03-04 | 2026-03-10 |
| Effect of Coffee on Postdural Puncture Headache After Cesarean Section Coffee Consumption - Postdural Puncture Headache | Not applicable | Completed | Hacettepe University | 89 | 2026-02-20 | 2026-07-23 |
| Efficacy of Sphenopalatine Block Compared to Blood Patch in the Management of Post-dural Puncture Headaches Sphenopalatine Ganglion Block, Blood patch - PDPH, Post Dural Puncture Headache | Phase 3 | Recruiting | University Hospital, Clermont-Ferrand | 80 | 2026-02-19 | 2026-02-27 |
| Ultrasonographic ONSD as a Predictor of PDPH in Spinal Anesthesia for Cesarean Delivery Study Cohort (Single Cohort) - Cesarean Section Complications | Not yet recruiting | Al-Azhar University | 150 | 2026-01-28 | 2026-01-22 | |
| "Isometric Lower Limbs Exercises Affect on Cardiac Parameters and Headache in Patient After Spinal Anesthesia" Lower Limb Isometric Exercise - Post Dural Puncture Headache | Not applicable | Active not recruiting | Karbala University | 120 | 2026-01-15 | 2026-04-23 |
| Ultrasonographic Optic Nerve Sheath Diameter in Postdural Puncture Headache Diagnosis Ultrasonographic Measurement of Optic Nerve Sheath Diameter (ONSD) - Anesthesia, Local, Headache | Completed | Ankara City Hospital Bilkent | 176 | 2025-08-08 | 2026-02-10 | |
| Neutrophil to Lymphocyte Ratio and Postdural Headache PDPH - Preoperative Neutrophil-to-Lymphocyte Ratio (NLR), Postdural Puncture Headache | Recruiting | Istinye University | 821 | 2025-07-12 | 2025-07-24 | |
| Optic Nerve Sheath Diameter in Postspinal Headache Post-Dural Puncture Headache | Completed | Konya City Hospital | 40 | 2025-07-01 | 2025-12-09 | |
| Evaluation of Post-dural Puncture Headache in Female Patients Undergoing Obstetric and Non-obstetric Surgery Spinal anesthesia - Post-Dural Puncture Headache | Completed | Duzce University | 112 | 2025-05-30 | 2026-05-22 | |
| Brochure-Supported Telemedicine Management of Postdural Puncture Headache Standard Information and Standard Telephone Follow-up, Brochure-Supported Structured Telemedicine Counseling - Postdural Puncture Headache (PDPH), Treatment Adherence and Compliance | Not applicable | Completed | Yuzuncu Yil University | 160 | 2025-05-01 | 2026-07-17 |
| Evaluation of Postoperative Hearing Loss After Spinal Anesthesia for Elective Cesarean Section in Pregnant Women Hearing Loss; Post-Dural Puncture Headache; Cesarean Delivery | Active not recruiting | Duzce University | 53 | 2025-03-25 | 2026-07-13 | |
| A Prospective Cohort Study to Evaluate the Safety, Efficacy, and Usability of the EpiZact Device EpiZact-assisted epidural placement - Postdural Puncture Headache, Epidural Analgesia, Obstetric | Phase 4 | Not yet recruiting | Oregon Health and Science University | 100 | 2025-03-15 | 2025-02-14 |
| Comparison of Nebulized Neostigmine/Atropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache Following Subarachnoid Block in Parturient Undergoing Elective Cesarean Section. A Randomized, Clinical Trial. lidocaine group ( nebulized lidocaine + saline) total volume 4 ml - Post-Dural Puncture Headache | Early Phase 1 | Recruiting | Minia University | 111 | 2025-02-20 | 2026-08-12 |
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Headache (10) · Agnosia (6) · Headache Disorders (5) · Cerebrospinal Fluid Leak (3) · Hypotension (3) · Intracranial Hypotension (3) · Back Pain (2) · Labor Pain (2) · Leukemia (2) · Lymphoma (2) · Pain (2) · Postoperative Nausea and Vomiting (2) · Bradycardia (1) · Central Nervous System Diseases (1)
Brain Diseases (119) · Central Nervous System Diseases (118) · Headache Disorders, Secondary (118) · Nervous System Diseases (118) · Headache Disorders (114) · Pathological Conditions, Signs and Symptoms (25) · Signs and Symptoms (24) · Neurologic Manifestations (22) · Pain (13) · Neurobehavioral Manifestations (6) · Perceptual Disorders (6) · Pathologic Processes (4) · Cardiovascular Diseases (3) · Craniocerebral Trauma (3) · Trauma, Nervous System (3)
Sphenopalatine Ganglion Block (15) · Blood Patch, Epidural (9) · Saline Solution (8) · Sodium Chloride (8) · Lidocaine (6) · Neostigmine (6) · Acetaminophen (5) · Aminophylline (4) · Conservative Treatment (4) · Dexamethasone (4) · Bupivacaine (3) · Caffeine (3) · Pregabalin (3) · Sumatriptan (3) · Theophylline (3)
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