123 completed, 25 unknown, 7 recruiting, 6 terminated. 81 Phase 4, 38 Not applicable, 25 Phase 3, 22 Phase 2, 8 Phase 1.
Follow Neostigmine: new trials by email Literature Review of Neostigmine trials Research Report on Neostigmine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Neostigmine and Sugammadex on the Optic Nerve Sheath Diameter Sugammadex 2 mg/kg, Neostigmine + Atropine - Neuromuscular Blockade Reversal Agent | Phase 4 | Completed | Cukurova University | 86 | 2026-06-25 | 2026-10-21 |
| Antagonism of Neostigmine in Continuous Infusion of Mivacurium Neostigmine - Neuromuscular Blocking Agents | Not applicable | Not yet recruiting | Beijing Tongren Hospital | 120 | 2026-05-01 | 2026-04-13 |
| Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery Neostigmine + Atropine, Sugammadex - Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus | Phase 3 | Not yet recruiting | Xijing Hospital | 560 | 2026-01-01 | 2025-12-09 |
| Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function Sugammadex, Neostigmine - Residual Neuromuscular Block | Not applicable | Recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 240 | 2025-12-30 | 2026-06-22 |
| Emergence Agitation Neostigmine + Atropine, Sugamadex - Emergence Agitation, Nasal Surgery | Not applicable | Active not recruiting | Ain Shams University | 486 | 2025-10-30 | 2025-11-28 |
| Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease Rocuronium, Cisatracurium, Sugammadex - Post Operative Pulmonary Complications, Neuromuscular Blockade | Phase 4 | Recruiting | The University of Texas Medical Branch, Galveston | 490 | 2025-08-26 | 2026-10-20 |
| NMBA Reversal and Postoperative Urinary Retention Choice of reversal agent (sugammadex or neostigmine [with muscaranic antagonist]) - Neuromuscular Blocking Agents, Urinary Retention After Procedure | Active not recruiting | Beth Israel Deaconess Medical Center | 70000 | 2025-06-08 | 2026-01-23 | |
| To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU. Placebo drug ( normal saline ), neostigmine (reversal agent) - Tachycardia, Hypertension | Phase 1 / Phase 2 | Completed | Ziauddin University | 100 | 2025-03-12 | 2025-07-31 |
| Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries normal Saline, Neostigmine, Ketorolac - Post-Dural Puncture Headache | Phase 1 / Phase 2 | Not yet recruiting | Assiut University | 330 | 2024-12-15 | 2024-12-11 |
| Sugammadex on Laparoscopic Bariatric Surgery Sugammadex, Neostigmine - Laparoscopic Bariatric Surgery, Sugammadex | Not applicable | Not yet recruiting | Shanxi Bethune Hospital | 60 | 2024-12-01 | 2024-11-07 |
| Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl as Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries Magnesium Sulfate and Bupivacaine 0.125%, bupivacaine and Neostigmine, fentanyl and bupivacaine - Magnesium Sulfate, Neostigmine | Phase 4 | Not yet recruiting | Assiut University | 66 | 2024-12-01 | 2024-11-12 |
| Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade Sugammadex 1 mg/kg, Neostigmine + Atropine - Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade | Phase 1 / Phase 2 | Recruiting | Universitas Padjadjaran | 60 | 2024-11-05 | 2025-01-28 |
| Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine. sugammadex, Neostigmine - Perioperative Diaphragmatic Function | Phase 1 | Completed | Ain Shams University | 60 | 2024-08-26 | 2025-05-21 |
| Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping., Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping. - Acute Pain | Phase 4 | Unknown | Minia University | 180 | 2024-07-15 | 2024-07-16 |
| Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial 2 mg/kg sugammadex, 0.07 mg/kg neostigmine - Neuromuscular Blocks | Phase 3 | Recruiting | The Cleveland Clinic | 80 | 2024-06-01 | 2025-12-15 |
| The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery SUGAMMADEX SODIUM 100 Mg in 1 mL, Neostigmine - Neuromuscular Blockade | Not applicable | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 80 | 2024-06-01 | 2025-02-17 |
| Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis Sugammadex, Neostigmine - Reversal of Neuromuscular Blockade | Not applicable | Completed | Beijing Tongren Hospital | 62 | 2024-06-01 | 2025-04-02 |
| Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection Neostigmine Injectable Solution, Sugammadex injection - Intestinal Disease | Phase 4 | Completed | University of California, Irvine | 132 | 2024-04-17 | 2026-08-25 |
| Ability to Maintain Saturation Levels Without Oxygen Supplementation as a Extubation Criteria Without TOF Monitoring Equipment Train of four monitoring device intraoperative, Neostigmine, Air chalenge prior to extubation - Anesthesia Intubation Complication | Not applicable | Enrolling by invitation | University of Surabaya | 240 | 2024-04-01 | 2025-04-01 |
| The Impact of Sugammadex on Ileus After Abdominal Wall Reconstruction Neostigmine / Glycopyrrolate, Sugammadex - Hernia, Ventral, Ileus | Phase 4 | Completed | Clayton Petro | 184 | 2024-01-15 | 2025-11-21 |
Showing 20 of 174. Sign in to see all of them.
Delayed Emergence from Anesthesia (18) · Pain, Postoperative (6) · Post-Dural Puncture Headache (6) · Obesity, Morbid (3) · Postoperative Complications (3) · Postoperative Nausea and Vomiting (3) · Spinal Cord Injuries (3) · Arrhythmias, Cardiac (2) · Bradycardia (2) · Critical Illness (2) · Emergence Delirium (2) · Ileus (2) · Intestinal Diseases (2) · Muscle Hypotonia (2) · Neurogenic Bowel (2)
Merck Sharp & Dohme LLC (14) · Assiut University (8) · Seoul National University Hospital (7) · Ain Shams University (5) · Cairo University (5) · Mansoura University (4) · Yonsei University (4) · Alexandria University (3) · James J. Peters Veterans Affairs Medical Center (3) · The Cleveland Clinic (3) · Beijing Tongren Hospital (2) · Campus Bio-Medico University (2) · Cukurova University (2) · Emory University (2) · Leiden University Medical Center (2)
United States (42) · Egypt (27) · South Korea (14) · Belgium (9) · Italy (7) · China (6) · Denmark (6) · Turkey (Türkiye) (6) · Germany (5) · Finland (4) · Malaysia (4) · Netherlands (4) · Australia (3) · Austria (3) · Canada (3)
Brandon M Togioka, MD (2) · Guyan Wang (2) · Tiffany Moon, MD (2) · Abeed Chowdhury, MB ChB BSc MRCS (1) · Abualauon Elbiplaoy, lectural of anesthesia (1) · Adam M Thaler, DO (1) · AhYoung Oh, M.D Ph. D (1) · Ahmed I Elnaggar, MD (1) · Ahmed M Elshafie (1) · Ahmed M Shaat, MD (1) · Albert Dahan, MD, PhD, Professor (1) · Alex Sia (1)
PMID 20683334, PMID 18385265, PMID 18946293, PMID 19713265, PMID 24809482, PMID 28399799, PMID 10403850, PMID 10492412, PMID 10719950, PMID 10793585, PMID 10793602, PMID 11339776, PMID 12717123, PMID 1356374, PMID 14570796, PMID 15329580, PMID 16183681, PMID 16835255, PMID 17264722, PMID 17307778, PMID 17312210, PMID 17893459, PMID 18567675, PMID 1865208, PMID 19194156, PMID 19387176, PMID 19897823, PMID 20375901, PMID 20576632, PMID 20601860, PMID 20809967, PMID 20876699, PMID 20885293, PMID 22091288, PMID 22476448, PMID 22698066, PMID 23372884, PMID 23452344, PMID 23461992, PMID 23599531, PMID 23846960, PMID 23851450, PMID 2400077, PMID 24240315, PMID 24247230, PMID 24305646, PMID 24427455, PMID 24639018, PMID 24686347, PMID 24833824
2017 (4), 2009 (1), 2014 (1), 2018 (1), 2019 (1), 2023 (1)