285 completed, 34 unknown, 13 not yet recruiting, 13 recruiting. 199 Not applicable, 90 Phase 1, 29 Phase 4, 28 Phase 3, 23 Phase 2.
Follow Caffeine: new trials by email Literature Review of Caffeine trials Research Report on Caffeine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Placebo Effect on Cycling Performance: Laboratory Crossover Study Caffeine (6mg/kg), Placebo (Starch capsule) - Physical Performance, Placebo Effect | Not applicable | Not yet recruiting | Poznan University of Physical Education | 80 | 2027-01-01 | 2026-09-18 |
| DDI Study of ECC0509 With Metformin, Midazolam, and Caffeine ECC0509, Metformin, Caffeine - Steatohepatitis, Nonalcoholic, Osteo Arthritis | Phase 1 | Not yet recruiting | Eccogene | 40 | 2026-11-01 | 2026-10-14 |
| Predicting Response and Exposure Changes in Cirrhosis for Effectiveness Five-Drug CYP Probe Cocktail - Liver Cirrhosis | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 45 | 2026-11-01 | 2026-08-11 |
| Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill Run Caffeine, L-Citrulline, Exogenous Ketone (Beta-Hydroxybutyrate) - Exercise Physiology, Nutritional Supplementation | Not applicable | Recruiting | St. Louis University | 20 | 2026-10-01 | 2026-10-02 |
| The Effects of Acute Nitrate and Caffeine Co-ingestion on Discipline-Specific Exercise Performance. Caffeine, Dietary Nitrate (Beetroot Juice), Placebo (Maltodextrin Capsule) - Athletic Performance, Dietary Supplement | Not applicable | Not yet recruiting | Poznan University of Physical Education | 112 | 2026-10-01 | 2026-08-07 |
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| Placebo Effect in Field-Based Physical Performance Caffeine (6mg/kg), Placebo (Starch capsule), Sham (No Treatment) - Physical Performance, Placebo Effect | Not applicable | Not yet recruiting | Poznan University of Physical Education | 120 | 2026-09-01 | 2026-08-03 |
| Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear Cells Caffeine (5 mg/kg), Placebo - Energy Metabolism | Not applicable | Not yet recruiting | Pontificia Universidad Catolica de Chile | 12 | 2026-09-01 | 2026-10-14 |
| TCP-600 Supplementation and Performance Response in Professional Football Players Placebo, Taurine, Caffeine - Athletic Performance, Cognitive Fatigue | Not applicable | Recruiting | Vizja University in Warsaw | 65 | 2026-09-01 | 2026-09-08 |
| Effects of L-Tyrosine and Caffeine on Performance in Elite Boxers Placebo, L-Tyrosine, Caffeine - Sports Performance | Not applicable | Not yet recruiting | Inonu University | 18 | 2026-09-01 | 2026-07-08 |
| Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players Placebo, Taurine Plus Caffeine, Taurine, Caffeine, and Phosphatidylserine - Mental Fatigue, Cognitive Performance | Not applicable | Completed | Vizja University in Warsaw | 65 | 2026-08-06 | 2026-09-14 |
| An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis Afimkibart, Caffeine, Warfarin - Active Ulcerative Colitis | Phase 1 | Recruiting | Hoffmann-La Roche | 25 | 2026-06-29 | 2026-10-16 |
| Caffeine and Prophylactic Noradrenaline Requirement During Cesarean Delivery Caffeine (200 mg), Placebo - Spinal Hypotension, Vasopressor | Not applicable | Not yet recruiting | Cairo University | 62 | 2026-06-16 | 2026-06-17 |
| Multi-Ingredient Supplementation in Professional Football Players Placebo, taurine, Caffeine - Sports Performance, Cognitive Performance During Physical Activity | Not applicable | Completed | Vizja University in Warsaw | 97 | 2026-06-14 | 2026-07-02 |
| Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg, Placebo - Common Cold/Flu, Nasal Congestion | Phase 3 | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 620 | 2026-05-08 | 2026-06-16 |
| Effects of Combined Rhodiola Rosea and Caffeine Supplementation on Dancesport Performance Placebo, Caffeine, Rhodiola Rosea Capsules - Dancesport Performance | Not applicable | Completed | Beijing Sport University | 48 | 2026-04-15 | 2026-07-08 |
| Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support Caffeine, Placebo - Preterm Birth, Caffeine | Phase 2 | Not yet recruiting | Queen's University | 62 | 2026-04-01 | 2026-03-10 |
| Caffeine and Wrestling Performance in Male Wrestlers of Different Weight Classes: A Randomized Crossover Trial Caffeine - Athletic Performance, Caffeine | Not applicable | Completed | Islamic Azad University, Abadan Branch | 95 | 2026-03-30 | 2026-10-22 |
| A Study to See if an Energy Drink With Caffeine and Green Tea Increases Fat Burning When Exercising Active (Green tea and caffeine), Placebo - Exercise | Phase 4 | Active not recruiting | RDC Clinical Pty Ltd | 36 | 2026-03-26 | 2026-09-09 |
| Caffeine Strategies and Fat Oxidation Caffeine (Guinama Anhydrous Powder), Caffeine (Nescafé Classic Coffee), Caffeine (Kafewake Gum) - Fat Metabolism, Caffeine | Not applicable | Enrolling by invitation | Universidad Rey Juan Carlos | 10 | 2026-03-15 | 2026-04-29 |
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PMID 33388079, PMID 40550198, PMID 41535923, PMID 10364418, PMID 11412143, PMID 11782649, PMID 11838581, PMID 11839447, PMID 12439645, PMID 15834219, PMID 15879163, PMID 16804691, PMID 16904537, PMID 17560739, PMID 18770076, PMID 19220646, PMID 19228873, PMID 19320625, PMID 19475459, PMID 19573497, PMID 20629111, PMID 21045179, PMID 21092089, PMID 21464363, PMID 21726992, PMID 23368828, PMID 23462927, PMID 23686786, PMID 23724879, PMID 23869233, PMID 23917460, PMID 24010809, PMID 24018772, PMID 24094754, PMID 24445955, PMID 24690589, PMID 24722393, PMID 24905629, PMID 25023200, PMID 25081280, PMID 25414797, PMID 25548331, PMID 25613340, PMID 25726515, PMID 25740906, PMID 26117308, PMID 26344676, PMID 27044596, PMID 27054321, PMID 27411694
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