4068 completed, 1208 recruiting, 1155 terminated, 1022 unknown. 3655 Phase 2, 3029 Phase 1, 809 Not applicable, 802 Phase 3, 173 Phase 4.
Follow Leukemia: new trials by email Literature Review of Leukemia trials Research Report on Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Evaluating Subcutaneous Versus Intravenous Blinatumomab in Newly Diagnosed Adults With B-cell Precursor Acute Lymphoblastic Leukaemia Blinatumomab, HyperCVAD - Philadelphia Chromosome Negative B-cell Precursor Acute Lymphoblastic Leukemia | Phase 3 | Not yet recruiting | Amgen | 560 | 2028-06-30 | 2026-09-15 |
| Pyronaridine in Acute Myeloid Leukemia (AML) Pyronaridine Tetraphosphate - Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL) | Phase 2 | Suspended | Armaceutica, Inc. | 200 | 2028-02-21 | 2026-10-19 |
| Genetic Ablation of CD33 in HSC to Broaden the Therapeutic Index of CD33-directed Immunotherapy in Patients with AML Donor-derived CD34+ HSC with CRISPR/Cas9-mediated CD33 deletion, Gemtuzumab Ozogamicin - Relapsed/Refractory Acute Myeloid Leukemia (AML) | Phase 1 | Not yet recruiting | German Cancer Research Center | 12 | 2028-01-01 | 2025-03-14 |
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| A Phase 1 Open-Label, Dose-Ranging Safety and Pharmacokinetics Study of Oral Cladribine in Patients With Acute Myeloid Leukemia (AML) Cytarabine, Oral Cladribine - Acute Myeloid Leukemia (AML) | Phase 1 / Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 58 | 2027-12-01 | 2026-08-25 |
| Zanubrutinib and Sonrotoclax for the Treatment of Relapsed Chronic Lymphocytic Leukemia /Small Lymphocytic Leukemia, ZeuS-2 Trial Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | Phase 2 | Not yet recruiting | City of Hope Medical Center | 44 | 2027-08-04 | 2026-09-10 |
| VR-PAT and fNIRS to Identify CNS Biomarkers of Pain VR-PAT - Acute Pain, Pediatric ALL | Not applicable | Not yet recruiting | Nationwide Children's Hospital | 4 | 2027-07-01 | 2026-09-09 |
| CAR-T Immunotherapy Targeting CD19- ALL 4SCAR-CD22/CD123/CD38/CD10/CD20/TSLPR - B-cell Leukemia | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2027-07-01 | 2026-11-02 |
| Universal 4SCAR7U Targeting CD7-positive Malignancies Universal CD7-specific CAR gene-engineered T cells - T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-11-02 |
| Universal CAR-T Cells Targeting AML CLL-1, CD33, CD38 and/or CD123-specific universal CAR- T cells - Acute Myeloid Leukemia | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-11-02 |
| A Clinical Study to Investigate the Safety and Efficacy of Off-the-Shelf iNKT Cell Injection Targeting CD33/CD70 in Adult Patients With Relapsed/Refractory Acute Myeloid Leukemia GT737 Injection - Relapsed/Refractory Acute Myeloid Leukemia (AML) | Early Phase 1 | Not yet recruiting | Grit Biotechnology | 36 | 2027-05-01 | 2026-09-11 |
| Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM Trial Autologous Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Aspiration - Plasma Cell Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 74 | 2027-04-20 | 2026-10-26 |
| Genetically Engineered Cells (BAFFR-CAR T Cells) for the Treatment of Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia and B-cell Lymphoblastic Lymphoma Autologous BAFFR-targeting CAR T Cells, Biospecimen Collection, Bone Marrow Aspiration - Recurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 16 | 2027-04-17 | 2026-08-11 |
| Phase I Safety Clinical Trial of Anti-CD19 CAR-T Therapy COL01 for the Treatment of Adults With Relapsed or Refractory B-cell Lymphoid Neoplasms: First-in-human Administration, COLIBRI. CAR-T anti-CD19 COL01 - Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia, Lymphoid Malignancies | Phase 1 | Not yet recruiting | GUSTAVO SALGUERO | 12 | 2027-04-01 | 2026-10-20 |
| 2 Gy Total Body Irradiation As Part Of Conditioning Treatment For Patients With Acute Lymphoblastic Leukemia Undergoing CAR T Cell Therapy CAR T cell therapy - Acute Lymphoblastic Leukemia | Not applicable | Not yet recruiting | M.D. Anderson Cancer Center | 20 | 2027-03-01 | 2026-10-05 |
| Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration Non-Interventional Study - Childhood Acute Lymphoblastic Leukemia, Childhood Lymphoblastic Lymphoma | Not yet recruiting | Mayo Clinic | 20 | 2027-02-01 | 2026-04-02 | |
| Maintenance Treatment With Imetelstat in Patients With High-Risk Myeloid Neoplasms After Allo-SCT imetelstat - High-risk Myeloid Malignancy, Allogenic Stem Cell Transplantation | Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 27 | 2027-02-01 | 2026-11-02 |
| The AYA Oncology Self-care Movement Educational Website, #AYAOSM - Acute Lymphobkastic Leukemia, Medication Adherence | Not applicable | Not yet recruiting | Northwestern University | 200 | 2027-02-01 | 2026-10-30 |
| Axatilimab Combined With Decitabine/Venetoclax for the Treatment of TP53-mutated AML Decitabine, Venetoclax, Axatilimab - Acute Myeloid Leukemia, TP53 Gene Mutation | Phase 1 | Not yet recruiting | Northside Hospital, Inc. | 32 | 2027-01-31 | 2026-10-16 |
| A Study of Patient Characteristics, Co-Morbidities, and Treatment Patterns in Chronic Myeloid Leukemia Patients in Kuwait Leukemia, Myeloid, Chronic-Phase | Not yet recruiting | Novartis Pharmaceuticals | 400 | 2027-01-31 | 2026-11-10 |
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Leukemia, Myeloid, Acute (3592) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2522) · Leukemia, Lymphocytic, Chronic, B-Cell (2018) · Myelodysplastic Syndromes (1406) · Lymphoma (1127) · Lymphoma, Non-Hodgkin (1071) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (878) · Lymphoma, Follicular (760) · Lymphoma, Mantle-Cell (731) · Lymphoma, Large B-Cell, Diffuse (709) · Burkitt Lymphoma (698) · Multiple Myeloma (676) · Lymphoma, B-Cell, Marginal Zone (647) · Hodgkin Disease (632)
Hemic and Lymphatic Diseases (8795) · Neoplasms by Histologic Type (8775) · Hematologic Diseases (8699) · Neoplasms (8380) · Immune System Diseases (5009) · Immunoproliferative Disorders (4919) · Lymphoproliferative Disorders (4864) · Lymphatic Diseases (4850) · Leukemia, Myeloid (4525) · Leukemia, Lymphoid (4253) · Pathological Conditions, Signs and Symptoms (3946) · Pathologic Processes (3850) · Disease Attributes (3668) · Chronic Disease (3257)
Cytarabine (908) · Cyclophosphamide (859) · venetoclax (506) · fludarabine (490) · Azacitidine (475) · fludarabine phosphate (454) · Rituximab (421) · Methotrexate (408) · Etoposide (315) · Filgrastim (291) · Daunorubicin (287) · Busulfan (284) · Vincristine (283) · Dexamethasone (282) · Peripheral Blood Stem Cell Transplantation (255)
M.D. Anderson Cancer Center (488) · National Cancer Institute (NCI) (428) · Fred Hutchinson Cancer Center (188) · Novartis Pharmaceuticals (163) · Children's Oncology Group (155) · Memorial Sloan Kettering Cancer Center (137) · City of Hope Medical Center (103) · St. Jude Children's Research Hospital (103) · Institute of Hematology & Blood Diseases Hospital, China (92) · Gruppo Italiano Malattie EMatologiche dell'Adulto (90) · Masonic Cancer Center, University of Minnesota (89) · Dana-Farber Cancer Institute (78) · AbbVie (74) · The First Affiliated Hospital of Soochow University (69) · Bristol-Myers Squibb (64)
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Jorge Cortes, MD (29) · Brenda Sandmaier (18) · Farhad Ravandi-Kashani, MD (17)
PMID 41671463, PMID 32499241, PMID 34515338, PMID 35622074, PMID 34398557, PMID 33394722, PMID 24383844, PMID 25527568, PMID 33242441, PMID 23524640, PMID 35235189, PMID 35829925, PMID 36064577, PMID 36184192, PMID 38620092, PMID 23065508, PMID 23620574, PMID 28835440, PMID 30885996, PMID 31375516, PMID 42013378, PMID 29358183, PMID 31196847, PMID 34048072, PMID 37267439, PMID 37341189, PMID 39121442, PMID 22965967, PMID 24923295, PMID 25361995, PMID 26182309, PMID 27209293, PMID 28054442, PMID 29618479, PMID 30062662, PMID 31023700, PMID 31171508, PMID 34162404, PMID 34608724, PMID 34865212, PMID 35982483, PMID 36815378, PMID 38295280, PMID 38446568, PMID 38507688, PMID 39368878, PMID 39563886, PMID 40266025, PMID 41429239, PMID 41592282
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