30 completed, 10 recruiting, 9 unknown, 4 terminated. 24 Not applicable, 7 Phase 2, 7 Phase 3, 4 Phase 4.
Follow Cerebrospinal Fluid Leak: new trials by email Literature Review of Cerebrospinal Fluid Leak trials Research Report on Cerebrospinal Fluid Leak
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety Evaluation of Absorbable and Moldable Skull Base Support Plates in Extended Endoscopic Endonasal Transsphenoidal Surgery: A Prospective, Randomized, Controlled Study Absorbable and moldable skull base support plate - Sellar Tumor, Endonasal Surgery | Phase 2 | Recruiting | Nanfang Hospital, Southern Medical University | 126 | 2026-04-01 | 2026-04-20 |
| Bed Rest Duration and Outcomes in Endoscopic Skull Base Reconstruction non-bed-rest, 2-day bed-rest, 1-day bed-rest - Skull Base | Not applicable | Not yet recruiting | The Affiliated Hospital of Qingdao University | 316 | 2026-04-01 | 2026-04-07 |
| Immiseal™ Dural Sealant Post-Market Registry Study Dural Defect, Cerebrospinal Fluid Leak | Recruiting | Medprin Regenerative Medical Technologies Co., Ltd. | 85 | 2026-02-17 | 2026-06-16 | |
| Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors Brain Tumor Adult, Brain Tumor Benign | Recruiting | Medical University of Warsaw | 200 | 2026-02-03 | 2026-05-22 | |
| Evaluation of Internal Nasal Splint-Supported Free Graft Versus Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks Internal Nasal Splint-Supported Free Graft, Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks - CSF Leak | Not applicable | Recruiting | Kafrelsheikh University | 20 | 2026-02-01 | 2026-05-27 |
| Conservative vs Interventional Management of Postsurgical CSF Pseudomeningocele Lumbar Drainage, Pseudomeningocele Puncture, Puncture with Fibrin Glue Application - CSF Leak, CSF Pressure Increased | Not applicable | Recruiting | Charles University, Czech Republic | 60 | 2025-11-01 | 2026-05-29 |
| Safety and Efficacy Evaluation of ArtiFix® Sealant Graft in Subjects Requiring Dural Repair Following Neurosurgery ArtiFix® is a surgical dural sealant graft intended to close dural defects following cranial and spine surgeries. - Cerebrospinal Fluid Leak, Dural Tear | Not applicable | Not yet recruiting | Nurami Medical Ltd | 20 | 2025-11-01 | 2025-08-14 |
| NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant - CerebroSpinal Fluid (CSF) Leak | Not applicable | Recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 225 | 2025-08-15 | 2025-10-14 |
| Acetazolamide to Reduce Spinal Fluid Leaks After Spine Surgery. Acetazolamide, Standard Care (in control arm) - Cerebrospinal Fluid Leak, Dural Tear | Phase 4 | Completed | Ain Shams University | 26 | 2025-04-06 | 2026-10-15 |
| The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH) CerebroSpinal Fluid (CSF) Leak | Recruiting | University Hospital Freiburg | 2000 | 2024-11-04 | 2024-12-02 | |
| Study to Evaluate the Effectivity and Safety of BIOSCAFF®H Compared to DuraGen®, in Patients Undergoing Dural Repair Human collagen matrix graft, Bovine collagen matrix graft - Cerebrospinal Fluid Leakage | Terminated | Top Health S.A.P.I DE C.V. | 2 | 2024-09-03 | 2025-02-25 | |
| Effect of Spinal Needle Type on Optic Nerve Sheath Diameter 25 PP, 25 Q, 27 Q - Spinal Anesthesia, Intracranial Pressure Change | Not applicable | Unknown | Bagcilar Training and Research Hospital | 165 | 2024-08-15 | 2024-07-30 |
| Spinal CSF Leaks in Chronic Subdural Hematoma Chronic Subdural Hematoma | Recruiting | University of Freiburg | 220 | 2024-06-24 | 2024-06-26 | |
| Dural Medical Adhesive for Watertight Sealing in Dural Repair Dural medical adhesive, Standard dural reinforcement surgery - Spinal Dural Defect, Cerebrospinal Fluid Leakage | Phase 3 | Completed | Medprin Regenerative Medical Technologies Co., Ltd. | 141 | 2024-05-29 | 2026-08-10 |
| CraniSeal Post Approval Study CraniSeal, DuraSeal - Leak, Cerebrospinal Fluid | Phase 4 | Recruiting | Pramand LLC | 224 | 2024-05-29 | 2026-02-20 |
| Using Polyglycolic Acid Mesh Prevents Cerebrospinal Fluid Leakage polyglycolic acid(Neoveil) - Pituitary Tumor, Cerebrospinal Fluid Leakage | Not applicable | Unknown | National Taiwan University Hospital | 30 | 2023-12-01 | 2024-06-25 |
| Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery Non-Absorbable Packing (Silastic Splint), PuraGel (RADA16) Hydrogel - Skull Base Neoplasms, Cerebrospinal Fluid Leakage | Not applicable | Recruiting | Indiana University | 30 | 2023-10-09 | 2026-08-27 |
| Bed Rest on the Effect of CSF Leakage Repair After Transsphenoidal Pituitary Surgery Bed rest - Adenoma Pituitary, CSF Leakage | Not applicable | Unknown | National Taiwan University Hospital | 180 | 2023-03-02 | 2024-04-16 |
| Comparison of Duration of CSF Leak in Post Traumatic Patients Managed by Early Lumbar Drain vs Conservative Treatment lumbar drain - CSF Leakage | Not applicable | Unknown | Rawalpindi Medical College | 60 | 2023-02-21 | 2023-03-31 |
| Observational Pilot Study With TachoSil as a Ventricular Sealant TachoSil - Intraventricular Neoplasm | Completed | Germans Trias i Pujol Hospital | 20 | 2022-05-01 | 2023-02-08 |
Showing 20 of 59. Sign in to see all of them.
Cerebrospinal Fluid Otorrhea (15) · Cerebrospinal Fluid Rhinorrhea (11) · Pituitary Neoplasms (3) · Post-Dural Puncture Headache (3) · Headache (2) · Intracranial Hypotension (2) · Postoperative Complications (2) · Subarachnoid Hemorrhage (2) · Aneurysm (1) · Brain Neoplasms (1) · Cerebral Ventricle Neoplasms (1) · Cranial Nerve Diseases (1) · Craniocerebral Trauma (1) · Facial Neuralgia (1)
Nervous System Diseases (59) · Neurologic Manifestations (59) · Pathological Conditions, Signs and Symptoms (59) · Signs and Symptoms (59) · Trauma, Nervous System (59) · Wounds and Injuries (59) · Craniocerebral Trauma (58) · Brain Diseases (14) · Central Nervous System Diseases (14) · Rhinorrhea (11) · Signs and Symptoms, Respiratory (11) · Pathologic Processes (8) · Neoplasms (6) · Neoplasms by Site (6)
Acetazolamide (4) · Fibrin Tissue Adhesive (4) · Bed Rest (3) · Sodium Chloride (2) · TachoSil (2) · Early Ambulation (1) · Lidocaine (1) · Low Density Lipoprotein Receptor-Related Protein-1 (1) · Morphine (1) · Prone Position (1) · Punctures (1) · Saline Solution (1) · Second-Look Surgery (1) · Standard of Care (1) · Thrombin (1)
Ethicon, Inc. (3) · Medprin Regenerative Medical Technologies Co., Ltd. (3) · Integra LifeSciences Corporation (2) · National Taiwan University Hospital (2) · Nurami Medical Ltd (2) · Polyganics BV (2) · Universitaire Ziekenhuizen KU Leuven (2) · University of Miami (2) · Ain Shams University (1) · Al-Azhar University (1) · Bagcilar Training and Research Hospital (1) · Balgrist University Hospital (1) · Baxter Healthcare Corporation (1) · Charles University, Czech Republic (1) · Cook Research Incorporated (1)
United States (14) · Belgium (7) · Germany (7) · China (6) · Switzerland (6) · Spain (5) · Netherlands (4) · Poland (4) · United Kingdom (4) · Czechia (3) · France (3) · Italy (3) · Austria (2) · Canada (2) · Egypt (2)
Richard Kocharian, MD, PhD (2) · Abel Huang, MD (1) · Andrew Tummon (1) · Asgeir S Jakola, MD PhD (1) · Bart Depreitere, MD, PhD (1) · Beni Camacho Perez, PhD (1) · Brenda Vega Ruiz, PhD (1) · Farideh Nejat, MD (1) · Feyce Peralta, MD (1) · Harendra Arora, MD, MBA (1) · Ivan Segura Duran, M.D. (1) · James Hart, MD (1)
PMID 12102194, PMID 15147817, PMID 16509475, PMID 18395825, PMID 19301105, PMID 20556438, PMID 21672441, PMID 22120335, PMID 22282887, PMID 22771458, PMID 22800729, PMID 22823893, PMID 23218510, PMID 24243224, PMID 24524819, PMID 24760464, PMID 25036199, PMID 25296539, PMID 25768686, PMID 26504833, PMID 26517563, PMID 26824595, PMID 27813467, PMID 28083041, PMID 28117963, PMID 28324618, PMID 28456077, PMID 28529027, PMID 28597302, PMID 28729143, PMID 28751035, PMID 29232819, PMID 30302540, PMID 30485224, PMID 31058968, PMID 31935784, PMID 32361024, PMID 33380952, PMID 33538867, PMID 34321304, PMID 34499261, PMID 34916315, PMID 35858894, PMID 36959672, PMID 38394657, PMID 38727726, PMID 39331127, PMID 39465875, PMID 7608226
2009 (1), 2014 (1), 2015 (1)