90 completed, 7 unknown, 4 terminated, 2 recruiting. 26 Phase 3, 23 Phase 1, 19 Not applicable, 17 Phase 4, 12 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache Theophylline, Sumatriptan, Gabapentin - Theophylline, Sumatriptan | Not applicable | Recruiting | Tanta University | 75 | 2024-12-01 | 2026-04-07 |
| Migraine Attack Treatment Response Molecular and Clinical BiOmarkers (MAMBO) Phase I Sumatriptan - Migraine Disorders | Unknown | Hospital Universitari Vall d'Hebron Research Institute | 108 | 2024-01-25 | 2024-10-28 | |
| Nebulized Dexmedetomidine Versus Oral Sumatriptan in Treatment of Post Dural Puncture Headache in Cesarean Section Precedex, Sumatriptan 25 mg - Post-Dural Puncture Headache | Not applicable | Completed | Fayoum University Hospital | 48 | 2023-11-27 | 2025-03-12 |
| Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin Sumatriptan, Ubrogepant - Migraine | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 20 | 2022-03-15 | 2023-03-28 |
| Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine Levcromakalim, Sumatriptan, Saline - Migraine Without Aura, Headache | Not applicable | Completed | Danish Headache Center | 24 | 2022-03-15 | 2025-01-22 |
| Mirtazapine vs Sumatriptan in the Treatment of Postdural Puncture Headache Mirtazapine, Sumatriptan, Placebo - Headache | Phase 4 | Completed | Ain Shams University | 210 | 2021-11-15 | 2024-01-22 |
| Drug-Drug Interaction Study of Evobrutinib and Transporter Substrates Evobrutinib (45mg), Digoxin (0.25mg), Metformin (10mg) - Healthy | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 40 | 2021-10-04 | 2025-12-05 |
| Sumatriptan and Glucose Sumatriptan 100 mg - Overweight | Early Phase 1 | Unknown | Cambridge University Hospitals NHS Foundation Trust | 12 | 2021-01-04 | 2020-12-30 |
| A STUDY TO EVALUATE THE EFFECT OF PF-06651600 ON PHARMACOKINETICS OF SINGLE DOSE SUMATRIPTAN IN HEALTHY PARTICIPANTS. Sumatriptan, PF-06651600 - Healthy Volunteers | Phase 1 | Completed | Pfizer | 10 | 2020-06-15 | 2020-09-03 |
| Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache Theophylline Anhydrous Oral Tablet, Sumatriptan Succinate Oral Tablet - Post-Dural Puncture Headache | Phase 4 | Completed | Damanhour Teaching Hospital | 60 | 2020-02-15 | 2021-06-03 |
| Safety, Tolerability and Pharmacokinetics of ALD1910 in Healthy Men and Woman ALD1910, Sumatriptan - Migraine | Phase 1 | Completed | H. Lundbeck A/S | 96 | 2019-09-24 | 2020-09-23 |
| A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain Arm 1: CL-H1T, Arm 2: CL-H1T, Arm 3: Sumatriptan Succinate 100 mg capsule - Migraine, Pain | Phase 2 | Completed | Charleston Laboratories, Inc | 475 | 2019-02-01 | 2019-11-01 |
| PACAP38 Induced Headache and Rosacea-like Symptoms in Patients With Rosacea Imigran, Isotonic Saline - Rosacea | Not applicable | Completed | Danish Headache Center | 38 | 2018-11-12 | 2020-03-26 |
| Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants Tranexamic acid (TXA), labetalol, metformin - Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | Recruiting | Duke University | 1600 | 2018-10-04 | 2026-07-29 | |
| The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects Sumatriptan, Ketorolac - Headache | Not applicable | Completed | Danish Headache Center | 34 | 2018-08-01 | 2020-01-02 |
| Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks sumatriptan 85mg and naproxen sodium 500mg, Placebo - Migraine in Adults | Phase 3 | Unknown | Peking University Third Hospital | 240 | 2018-08-01 | 2021-07-07 |
| PACAP38 Induced Headache, Migraine and Flushing in Patients With Migraine Imigran, Isotonic Saline, Pituitary adenylate cyclase-activating peptide-38 - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 37 | 2018-07-17 | 2020-06-22 |
| The Effect of Sumatriptan and Placebo on CGRP Induced Headache Calcitonin Gene Related Peptide, Sumatriptan 50 mg, Placebo Oral Tablet - Migraine | Not applicable | Completed | Danish Headache Center | 30 | 2018-02-15 | 2019-09-12 |
| Sofusa System With Sumatriptan (KC5010) Phase 1 Dose Escalation Safety and PK Study (KCC-SMT-002) Sumatriptan Succinate Oral Tablet, Transdermal delivery of sumatriptan succinate - Migraine Disorders | Phase 1 | Completed | Sorrento Therapeutics, Inc. | 19 | 2018-01-17 | 2022-08-10 |
| Study to Assess the Safety and Efficacy of ONZETRA® Xsail® for the Acute Treatment of Episodic Migraine With or Without Aura in Adolescents sumatriptan nasal powder, Placebo - Acute Migraine With or Without Aura | Phase 3 | Terminated | Currax Pharmaceuticals | 159 | 2017-11-02 | 2023-07-24 |
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Migraine Disorders (66) · Headache (14) · Epilepsy (4) · Migraine without Aura (3) · Post-Dural Puncture Headache (3) · Cluster Headache (2) · Cognitive Dysfunction (2) · Dysmenorrhea (2) · Migraine with Aura (2) · Pain (2) · Personal Satisfaction (2) · Post-Traumatic Headache (2) · Arthritis (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1)
GlaxoSmithKline (18) · Danish Headache Center (10) · Cady, Roger, M.D. (6) · NuPathe Inc. (5) · Eli Lilly and Company (3) · POZEN (3) · Pfizer (3) · Dr. Reddy's Laboratories Limited (2) · Montefiore Medical Center (2) · Mylan Pharmaceuticals Inc (2) · Novartis (2) · Optinose US Inc. (2) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (2) · Ranbaxy Laboratories Limited (2) · Teva Pharmaceuticals USA (2)
United States (60) · Denmark (11) · Egypt (4) · Canada (3) · India (3) · Australia (2) · Belgium (2) · Germany (2) · Japan (2) · Spain (2) · China (1) · Iran (1) · United Kingdom (1)
Roger K Cady, MD (7) · David Taylor (3) · Dorian Williams, M.D. (2) · Emma Katrine Hansen, Doctor (2) · Messoud Ashina, MD,PhD,DMSc (2) · Ahmed M Shaat, MD (1) · Ali Ziaee, MD (1) · Andrew Hershey, MD (1) · Annette C. Toledano, M.D. (1) · Benjamin W. Friedman, MD,MS (1) · Bernard P. Schachtel, MD (1)
PMID 17405970, PMID 19546766, PMID 20353434, PMID 20855373, PMID 21521204, PMID 24579886, PMID 11284463, PMID 16492233, PMID 17501849, PMID 17955107, PMID 18384420, PMID 19486178, PMID 20637969, PMID 20880898, PMID 21592098, PMID 21812775, PMID 21942531, PMID 22585767, PMID 22694484, PMID 23148799, PMID 23406052, PMID 23798725, PMID 23963355, PMID 23965396, PMID 23992438, PMID 24020994, PMID 25355310, PMID 25941016, PMID 26840902, PMID 27317706, PMID 28176235, PMID 28880380, PMID 29396788, PMID 29878341, PMID 30120600, PMID 30877622, PMID 32093617, PMID 32216457, PMID 33567890, PMID 33600826, PMID 35076931, PMID 39136260, PMID 40624944
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