9 completed, 4 recruiting, 3 unknown, 1 enrolling by invitation. 7 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 3, Not yet recruiting 1, Recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
Follow Intracranial Hypotension: new trials by email Literature Review of Intracranial Hypotension trials Research Report on Intracranial Hypotension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CVFs in SIH: EID vs. PCD CTM photon counting detector CT myelography (PCD- CTM), energy integrating detector CT myelography (EID-CTM) - Spontaneous Intracranial Hypotension | Not applicable | Recruiting | Duke University | 200 | 2026-05-21 | 2026-06-15 |
| Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension PRP Patch group, Whole Blood Patch Group - Spontaneous Intracranial Hypotension | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 218 | 2026-05-01 | 2026-05-27 |
| Blind Versus Targeted Epidural Patch With Autologous Platelet-rich Plasma for Spontaneous Intracranial Hypotension Targeted epidural PRP patch, Blind epidural PRP patch - Spontaneous Intracranial Hypotension | Not applicable | Withdrawn | Beijing Tiantan Hospital | 2025-12-20 | 2026-05-11 | |
| ONSD Changes and Treatment Response After Epidural Blood Patch in Spontaneous Intracranial Hypotension Spontaneous Intracranial Hypotension | Completed | Yonsei University | 23 | 2025-09-22 | 2026-07-02 | |
| Optic Nerve Sheath Diameter in Postspinal Headache Post-Dural Puncture Headache | Completed | Konya City Hospital | 40 | 2025-07-01 | 2025-12-09 | |
| Pathophysiology and Treatment of Cerebrospinal Hypotension Exploration Study Spontaneous Intracranial Hypotension, Intracranial Hypotension | Enrolling by invitation | Danish Headache Center | 400 | 2024-12-10 | 2025-02-06 | |
| Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension greater occipital nerve block - Spontaneous Intracranial Hypotension | Recruiting | University Health Network, Toronto | 34 | 2024-08-01 | 2026-01-16 | |
| Spinal CSF Leaks in Chronic Subdural Hematoma Chronic Subdural Hematoma | Recruiting | University of Freiburg | 220 | 2024-06-24 | 2024-06-26 | |
| The Blood Patch in the Management of Intracranial Hypotension Intracranial Hypotension | Unknown | University Hospital, Strasbourg, France | 50 | 2023-09-05 | 2024-07-12 | |
| A Clinical Registry of Spontaneous Intracranial Hypotension Transvenous Embolization of Cerebrospinal Fluid-Venous Fistula - Spontaneous Intracranial Hypotension | Recruiting | Mayo Clinic | 400 | 2023-06-18 | 2026-08-12 | |
| Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease Questionnaire - Marfan Syndrome | Completed | Assistance Publique - Hôpitaux de Paris | 90 | 2022-02-11 | 2025-09-12 | |
| Assessment of Ultrasonographic Measurement of Inferior Vena Cava Collapsibility Index in Prediction of Hypotension Associated With Tourniquet Release in Total Knee Replacement Surgeries Under Spinal Anesthesia ultrasound - Fluid Hypovolemia, Cerebrospinal | Completed | Ain Shams University | 60 | 2021-05-28 | 2022-10-03 | |
| Low Intracranial Pressure Treatment Strategies for Chronic Subdural Hematoma Patients low intracranial pressure strategy treatment, Atorvastatin plus Dexamethasone - Chronic Subdural Hematoma | Not applicable | Unknown | Huashan Hospital | 160 | 2020-08-04 | 2020-11-10 |
| Postoperative Changes in Optic Nerve Sheath Diameter in Patients Undergoing Spinal Anesthesia for Cesarean Delivery Intracranial Hypotension | Unknown | SMG-SNU Boramae Medical Center | 50 | 2020-04-01 | 2020-03-10 | |
| A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment TISSEEL - Cerebrospinal Fluid Leaks | Phase 2 | Completed | Duke University | 15 | 2017-12-18 | 2021-06-18 |
| Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension MRI algorithm, Lumbar puncture, Epidural patching - Intracranial Hypotension | Not applicable | Completed | Duke University | 5 | 2017-09-14 | 2020-07-28 |
| Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access Intraosseous, Hypertonic saline - Stroke, Intracranial Hypotension | Phase 2 | Completed | Ohio State University | 6 | 2017-04-21 | 2019-07-09 |
| Pituitary Function and Spontaneous Intracranial Hypotension Pituitary panel will be drawn pre-op and post-op for all patients. - Hyperprolactinemia, Spontaneous Intracranial Hypotension | Suspended | Cedars-Sinai Medical Center | 100 | 2015-07-01 | 2019-01-31 | |
| Spontaneous Intracranial Hypotension Treatment "SIHT" 24 hours Trendelenburg position, 24 hours bed rest, EBP - Spontaneous Intracranial Hypotension | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 64 | 2014-12-01 | 2022-04-21 |
| HES Patch Versus Blood Patch injection of HES " Voluven® ", blood patch - Intracranial Hypotension | Not applicable | Completed | University Hospital, Strasbourg, France | 20 | 2013-06-01 | 2019-08-20 |
Post-Dural Puncture Headache (3) · Hematoma, Subdural, Chronic (2) · Arachnodactyly (1) · Brain Edema (1) · Cerebrospinal Fluid Leak (1) · Cerebrospinal Fluid Otorrhea (1) · Hyperprolactinemia (1) · Low Back Pain (1) · Marfan Syndrome (1) · Signs and Symptoms (1) · Stroke (1) · Vertigo (1)
Brain Diseases (20) · Central Nervous System Diseases (20) · Nervous System Diseases (20) · Pathological Conditions, Signs and Symptoms (5) · Cardiovascular Diseases (4) · Neurologic Manifestations (4) · Cerebrovascular Disorders (3) · Craniocerebral Trauma (3) · Headache Disorders (3) · Headache Disorders, Secondary (3) · Signs and Symptoms (3) · Trauma, Nervous System (3) · Vascular Diseases (3) · Wounds and Injuries (3) · Chronic Disease (2)
Blood Patch, Epidural (2) · Atorvastatin (1) · Bed Rest (1) · Dexamethasone (1) · Fibrin Tissue Adhesive (1) · Head-Down Tilt (1) · Hydroxyethyl Starch Derivatives (1) · Saline Solution, Hypertonic (1) · Spinal Puncture (1) · Surveys and Questionnaires (1) · Ultrasonography (1)
Duke University (3) · Assistance Publique - Hôpitaux de Paris (2) · Beijing Tiantan Hospital (2) · University Hospital, Strasbourg, France (2) · Ain Shams University (1) · Cedars-Sinai Medical Center (1) · Danish Headache Center (1) · Huashan Hospital (1) · Konya City Hospital (1) · Mayo Clinic (1) · Ohio State University (1) · SMG-SNU Boramae Medical Center (1) · University Health Network, Toronto (1) · University of Freiburg (1) · Yonsei University (1)
United States (6) · France (4) · Canada (1) · China (1) · Denmark (1) · Egypt (1) · Germany (1) · South Korea (1) · Turkey (Türkiye) (1)
Henrik W Schytz, MD, Ph.D. DMSc (1) · Peter Kranz, MD (1) · Timothy J Amrhein, MD (1) · Vivien Bonert, MD (1) · Waleed Brinjikji, MD (1)