1243 completed, 296 unknown, 201 recruiting, 129 terminated. 883 Not applicable, 288 Phase 3, 232 Phase 2, 199 Phase 4, 129 Phase 1.
Follow Headache Disorders: new trials by email Literature Review of Headache Disorders trials Research Report on Headache Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Observational Study to Assess Migraine Prediction Tool Daily questionnaire - Migraine | Suspended | Theranica | 200 | 2030-01-01 | 2024-11-22 | |
| EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization TEMMA Endovascular Treatment - Migraine Disorders, Refractory Migraine | Not applicable | Not yet recruiting | Cortex Neurovascular | 25 | 2028-03-01 | 2026-10-20 |
| Behavior Therapy vs Education for Persistent Headache After Mild TBI Headache reprocessing, Headache education - Post-Traumatic Headache | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2027-10-01 | 2025-12-26 |
| Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo - Acute Mountain Sickness | Phase 4 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 30 | 2027-06-01 | 2026-07-01 |
| Nortriptyline Compared With Amitriptyline for Migraine Prevention at SQUH Nortriptyline, Amitriptyline - Migraine | Phase 4 | Not yet recruiting | Sultan Qaboos University | 90 | 2027-05-01 | 2026-10-02 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Multimodal Therapy for Somatosensory Tinnitus Multimodal physiotherapy for TMJ and Cervical spine, Combined Exercise Program (Aerobic + Resistance + Breathing), Tinnitus-Specific Psychological Support - Ear Noise, Tinnitus, Noise Induced | Not applicable | Not yet recruiting | Charles University, Czech Republic | 160 | 2027-01-01 | 2026-03-12 |
| Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine Atogepant 60 mg, Placebo - Migraine Disorders, Brain, Healthy Adult Participants | Phase 4 | Not yet recruiting | Konrad Peter Weber | 80 | 2027-01-01 | 2026-09-17 |
| A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine Neurostimulator - Resistant Migraine, Chronic Migraine Headache | Not applicable | Recruiting | Salvia BioElectronics | 150 | 2026-12-01 | 2026-08-28 |
| Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacks Low Sodium Oxybate, Placebo - Chronic Cluster Headache | Phase 2 | Not yet recruiting | Leiden University Medical Center | 52 | 2026-12-01 | 2026-08-25 |
| Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial Migraine Behavioral Treatment - Migraine, Headache | Not applicable | Not yet recruiting | Mayo Clinic | 24 | 2026-12-01 | 2026-06-16 |
| Comparing Spinal, Epidural, and Dural Puncture Epidural Anesthesia for Cesarean Delivery: Hemodynamics and Block Quality Spinal Anesthesia, Epidural Anesthesia, Dural Puncture Epidural Anesthesia - Hypotension After Neuraxial Anesthesia, Cesarean Section | Not applicable | Not yet recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 120 | 2026-12-01 | 2026-10-20 |
| Assessment of Head Awareness in Patients With Migraine in the Greek Population Migraine | Not yet recruiting | National and Kapodistrian University of Athens | 90 | 2026-11-01 | 2026-10-08 | |
| Validity and Reliability of the Greek WPAI:Migraine Migraine | Not yet recruiting | National and Kapodistrian University of Athens | 60 | 2026-11-01 | 2026-10-08 | |
| Osteopathic Care Combined With Physiotherapy and Pain Education for Cervicogenic Headache Osteopathic Care, Physiotherapy, Sham (No Treatment) - Cervicogenic Headache | Not applicable | Not yet recruiting | Centro Universitário Augusto Motta | 120 | 2026-11-01 | 2026-08-31 |
| Validity and Reliability of the Greek Pain Catastrophizing Scale Migraine | Not yet recruiting | National and Kapodistrian University of Athens | 130 | 2026-11-01 | 2026-10-07 | |
| Mindful RAVANS Study Cala-RAVANS (Model CR-2), Sham - mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 20 | 2026-11-01 | 2026-10-14 |
| Headache and Hormone Use Among Transgender Population in Thailand: A Cross-Sectional Online Study gender-affirming hormone therapy, Gender-Affirming Surgery, HIV Pre-Exposure Prophylaxis - Headache, Migraine | Not yet recruiting | Chulalongkorn University | 500 | 2026-11-01 | 2026-09-14 | |
| Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT) Eptinezumab, Placebo - Post Traumatic Headache | Phase 3 | Not yet recruiting | Sunnybrook Health Sciences Centre | 80 | 2026-11-01 | 2026-10-23 |
| Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale | Phase 3 | Recruiting | Columbia University | 32 | 2026-10-15 | 2026-10-08 |
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Migraine Disorders (1484) · Headache (408) · Post-Traumatic Headache (186) · Tension-Type Headache (131) · Cluster Headache (122) · Post-Dural Puncture Headache (119) · Migraine with Aura (113) · Pain (111) · Migraine without Aura (109) · Headache Disorders, Secondary (51) · Epilepsy (43) · Headache Disorders, Primary (42) · Neck Pain (39) · Chronic Pain (31)
Central Nervous System Diseases (2113) · Nervous System Diseases (2111) · Brain Diseases (2110) · Headache Disorders, Primary (1700) · Pathological Conditions, Signs and Symptoms (657) · Signs and Symptoms (616) · Neurologic Manifestations (596) · Pain (432) · Headache Disorders, Secondary (306) · Trigeminal Autonomic Cephalalgias (111) · Pathologic Processes (87) · Mental Disorders (85) · Behavior (84) · Cardiovascular Diseases (66)
Sumatriptan (74) · Topiramate (59) · erenumab (55) · Sodium Chloride (54) · rimegepant sulfate (41) · Botulinum Toxins, Type A (38) · Saline Solution (36) · Naproxen (32) · eptinezumab (28) · Lidocaine (26) · Metoclopramide (26) · fremanezumab (26) · Exercise (25) · rizatriptan (25) · Acetaminophen (23)
Danish Headache Center (102) · Pfizer (42) · Eli Lilly and Company (33) · GlaxoSmithKline (31) · Riphah International University (29) · Allergan (25) · Mayo Clinic (23) · Amgen (22) · Cairo University (21) · IRCCS National Neurological Institute "C. Mondino" Foundation (21) · AbbVie (20) · Theranica (20) · Montefiore Medical Center (19) · Thomas Jefferson University (19) · Merck Sharp & Dohme LLC (18)
United States (776) · Denmark (159) · Turkey (Türkiye) (149) · Italy (122) · Spain (109) · Germany (96) · Canada (94) · France (94) · China (79) · United Kingdom (79) · Egypt (72) · Belgium (57) · Norway (55) · Pakistan (53) · Israel (49)
Roger K Cady, MD (11) · Alit Stark Inbar, PhD (7) · Mia Minen, MD (6)
PMID 11914403, PMID 12807523, PMID 8984084, PMID 39982105, PMID 31482569, PMID 32576229, PMID 33781209, PMID 17405970, PMID 31952501, PMID 34823467, PMID 35978286, PMID 37965170, PMID 11284464, PMID 25500317, PMID 29368949, PMID 30496104, PMID 31291516, PMID 33142014, PMID 34264500, PMID 34874514, PMID 34928306, PMID 35076090, PMID 36125279, PMID 36739511, PMID 37303034, PMID 38462625, PMID 39648629, PMID 41235617, PMID 41652666, PMID 42839212, PMID 11112243, PMID 16135345, PMID 17175134, PMID 17955107, PMID 18662331, PMID 19453963, PMID 19486178, PMID 19546766, PMID 20353434, PMID 20487038, PMID 20548058, PMID 20647241, PMID 20855373, PMID 21521204, PMID 21711255, PMID 21883197, PMID 22520687, PMID 22590713, PMID 23567060, PMID 23731663
2019 (16), 2015 (10), 2018 (10), 2023 (9), 2016 (8), 2008 (4), 2014 (4), 2017 (3), 2025 (3), 2004 (2), K01NS124911 (2), R01AT011005 (2), UL1TR001082 (2), 1IK2RX001136-01A2 (1), 1UG3AT013498-01 (1)