184 completed, 54 unknown, 14 not yet recruiting, 7 active not recruiting. 273 Phase 2, 68 Phase 3, 53 Phase 1.
Follow Periodontal Diseases: new trials by email Literature Review of Periodontal Diseases trials Research Report on Periodontal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Thymus Vulgaris Mouthwash in the Management of Biofilm-Induced Gingivitis 0.2% Thymus vulgaris mouthwash, Chlorhexidine 0,12%, Placebo mouthwash - Plaque-Induced Gingivitis | Phase 2 | Not yet recruiting | University of Sulaimani | 60 | 2026-12-01 | 2026-11-02 |
| Adjunctive Melatonin Gel With MINST on GCF Galectin-3 and IL-1 in Stage III-IV Periodontitis Melatonin gel, Minimally Invasive Non-Surgical Therapy (MINST) - Periodontitis, Periodontitis (Stage 3) | Phase 2 | Not yet recruiting | Badr University | 40 | 2026-11-30 | 2026-11-09 |
| A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients Hydrogel - Periodontal Disease, Intrabony Periodontal Defects | Phase 1 / Phase 2 | Not yet recruiting | Siddharth Shanbhag | 40 | 2026-11-01 | 2026-05-14 |
| Effect of Gingival Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Management of Infra-bony Periodontal Defect Gingival mesenchymal stem cell derived small extracellular vesicles, β-calcium triphosphate (β-TCP) + collagen membrane - Infra-bony Periodontal Defect | Phase 2 | Not yet recruiting | Ain Shams University | 22 | 2026-10-01 | 2026-10-15 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2% - Bony Defects, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Cairo University | 63 | 2026-09-30 | 2026-08-27 |
| Surgical Treatment for Gingival Recessions After Orthodontic Treatment Coronally advanced flap and a de-epithelialized soft tissue graft, Coronally advanced flap and a subepithelial connective tissue graft, Coronally advanced flap and Mucoderm soft tissue collagen graft - Gingival Recessions, Generalized | Phase 2 / Phase 3 | Recruiting | Aziz Aliyev Azerbaijan State Advanced Training Institute for Doctors | 75 | 2026-09-01 | 2026-08-13 |
| Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects allopastic bone graft, cross-linked hyaluronic acid, Non-Incised Papillae Surgical Approach - Intrabony Periodontal Defect, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Mansoura University | 60 | 2026-08-01 | 2026-08-04 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Topical Phenytoin for Management of Gingival Recession phenytoin cream, Placebo - Gingival Recession | Phase 2 / Phase 3 | Not yet recruiting | Cairo University | 30 | 2026-06-01 | 2026-05-15 |
| Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles, Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles, Non- surgical periodontal therapy only - Stage III Periodontitis | Phase 2 | Completed | Nada Mahmoud Soliman | 27 | 2026-06-01 | 2026-10-21 |
| Efficacy and Safety of LP-005 Injection in Patients With Moderate-to-Severe Periodontitis LP-005 Injection, Placebo Injection - Periodontitis | Phase 2 | Not yet recruiting | Longbio Pharma (Suzhou) Co., Ltd. | 100 | 2026-05-01 | 2026-05-22 |
| Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial Xylitol Chewing gum, Sorbitol chewing gum - Preterm Birth, Low Birthweight Neonate | Phase 2 / Phase 3 | Recruiting | University of Washington | 6000 | 2026-03-26 | 2026-09-10 |
| Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis. Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Sterile 0.9% Saline Solution - Stage III Periodontitis | Phase 1 / Phase 2 | Completed | Assiut University | 24 | 2026-01-20 | 2026-11-06 |
| Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing MSC-Derived Exosomes, Platelet-rich fibrin (PRF) - Alveolar Bone Loss, Tooth Extraction | Phase 1 / Phase 2 | Recruiting | Al Salam University | 40 | 2026-01-15 | 2026-04-02 |
| N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC) - Apical Periodontitis | Phase 2 | Active not recruiting | Alexandria University | 40 | 2025-11-15 | 2025-12-30 |
| The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament Diclofenac Sodium, Calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Recruiting | British University In Egypt | 48 | 2025-11-01 | 2025-05-30 |
| Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis SALI-10 lozenge, Placebo lozenge - Gingivitis | Phase 2 | Active not recruiting | Ostia Sciences | 60 | 2025-09-01 | 2026-10-16 |
| Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique Minimally invasive non-surgical technique (MINST), nano-hyaluronic acid - Periodontal Disease, Periodontitis | Phase 1 / Phase 2 | Active not recruiting | Cairo University | 28 | 2025-07-15 | 2026-05-19 |
| Micro-Needling Technique Using Ozonated Olive Oil in Periodontal Diseases microneedling, scaling, Ozonated olive oil - Periodontal Diseases, Periodontitis and Treatment Need | Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-05-25 |
Showing 20 of 273. Sign in to see all of them.
Periodontitis (72) · Chronic Periodontitis (61) · Gingivitis (46) · Alveolar Bone Loss (19) · Gingival Recession (17) · Periapical Periodontitis (12) · Periodontal Pocket (12) · Dental Plaque (9) · Aggressive Periodontitis (7) · Diabetes Mellitus, Type 2 (6) · Peri-Implantitis (6) · Inflammation (5) · Plaque, Amyloid (5) · Pain, Postoperative (4)
Stomatognathic Diseases (272) · Mouth Diseases (270) · Pathological Conditions, Signs and Symptoms (90) · Periodontitis (85) · Pathologic Processes (78) · Gingival Diseases (66) · Chronic Disease (61) · Disease Attributes (61) · Infections (50) · Periodontal Atrophy (35) · Jaw Diseases (24) · Musculoskeletal Diseases (23) · Bone Diseases (21) · Tooth Diseases (20)
Tooth Exfoliation (18) · Root Planing (15) · Chlorhexidine (9) · Metronidazole (9) · Amoxicillin (6) · Metformin (6) · Doxycycline (5) · Aspirin (4) · Atorvastatin (4) · Control Groups (4) · Docosahexaenoic Acids (4) · Periodontal Debridement (4) · Rosuvastatin Calcium (4) · Saline Solution (4) · Alendronate (3)
Government Dental College and Research Institute, Bangalore (29) · Cairo University (8) · Ain Shams University (7) · SVS Institute of Dental Sciences (6) · Alexandria University (5) · Colgate Palmolive (5) · Islamic Azad University, Sanandaj (5) · Universidade Estadual Paulista Júlio de Mesquita Filho (5) · Tanta University (4) · The Forsyth Institute (4) · University of Baghdad (4) · Al-Azhar University (3) · Biomedical Development Corporation (3) · Dexcel Pharma Technologies Ltd. (3) · Dr. D. Y. Patil Dental College & Hospital (3)
Egypt (38) · United States (31) · India (26) · Brazil (15) · Iran (8) · Israel (8) · Canada (7) · Iraq (6) · Chile (5) · China (5) · Pakistan (5) · Turkey (Türkiye) (5) · Saudi Arabia (4) · France (3) · South Korea (3)
Avani R Pradeep, MDS (3) · Michael McGuire, DDS (3) · Parthasarathy Madurantakam, DDS, PhD (3) · A R Pradeep, MDS (2) · Ayyaz A Khan, PhD (2) · Bruno CV Gurgel, Doctor (2) · Dilip Khambete, MDS (2) · Jorge Gamonal Aravena, Proffesor (2) · Maha R. Taalab, PhD (2) · Makoto Tamura, Ph.D (2) · Mauro P Santamaria, PhD (2) · Mauro Santamaria, Professor (2) · Rampalli V Chandra, MDS;DNB (2) · Sergey Rubnikovich, Prof (2) · William V Giannobile, DDS, DMedSc (2)
PMID 33197289, PMID 12897619, PMID 18573992, PMID 12019707, PMID 15016256, PMID 15068108, PMID 15459950, PMID 16332231, PMID 16822220, PMID 16922026, PMID 18596969, PMID 19935025, PMID 20376235, PMID 21238793, PMID 21692628, PMID 21845241, PMID 21939106, PMID 22028505, PMID 22093005, PMID 22612364, PMID 22776413, PMID 23055593, PMID 24970858, PMID 25263143, PMID 25523604, PMID 25652112, PMID 26015680, PMID 27206923, PMID 27712462, PMID 27715376, PMID 27903262, PMID 28390459, PMID 28402343, PMID 28605006, PMID 28731373, PMID 29859084, PMID 30076613, PMID 30611255, PMID 30624092, PMID 31102044, PMID 31257591, PMID 31270648, PMID 32383274, PMID 32385871, PMID 32600259, PMID 32633595, PMID 32794485, PMID 32960889, PMID 33413320, PMID 33566077
R44HL101821 (2), 1UG3DE030401-01 (1), D43TW012274 (1), P50AT000076 (1), R01DE012108 (1), R01DE013796 (1), R01DE013850 (1), R01DE014242 (1), R01HD119029 (1), U01DE026934 (1), UL1RR025758-02 (1)