144 completed, 29 unknown, 13 not yet recruiting, 8 recruiting. 202 Phase 3, 68 Phase 2.
Follow Periodontal Diseases: new trials by email Literature Review of Periodontal Diseases trials Research Report on Periodontal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences Toothpaste Tablet, Conventional Toothpaste - Gingival Inflammation, Dental Caries | Phase 3 | Not yet recruiting | Loma Linda University | 50 | 2026-12-01 | 2026-07-10 |
| Periodontal Disease and Small Vulnerable Newborns in Rural Nepal: A Community-based Trial A package of oral health interventions, including a daily antiseptic oral rinse (alcohol-free cetylpyridinium chloride (0.075%)) - Preterm Birth, Low Birth Weight | Phase 3 | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 2280 | 2026-10-01 | 2026-07-09 |
| Clinical Study Examining the Control of Plaque and Gingivitis Silica Free Meridol, Meridol, Colgate Dental Product - Gingivitis | Phase 3 | Not yet recruiting | Colgate Palmolive | 135 | 2026-10-01 | 2026-09-25 |
| Surgical Treatment for Gingival Recessions After Orthodontic Treatment Coronally advanced flap and a de-epithelialized soft tissue graft, Coronally advanced flap and a subepithelial connective tissue graft, Coronally advanced flap and Mucoderm soft tissue collagen graft - Gingival Recessions, Generalized | Phase 2 / Phase 3 | Recruiting | Aziz Aliyev Azerbaijan State Advanced Training Institute for Doctors | 75 | 2026-09-01 | 2026-08-13 |
| Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment Active Oral Hygiene Regimen, Placebo Oral Hygiene Regimen - Periodontal Disease, Gingival Inflammation and Bleeding | Phase 3 | Not yet recruiting | Colgate Palmolive | 100 | 2026-09-01 | 2026-09-03 |
| New In Situ Model Design for Caries and Erosion 0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste - Caries, Erosive Tooth Wear | Phase 3 | Active not recruiting | Indiana University | 12 | 2026-08-03 | 2026-09-30 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste - Plaque, Dental Plaque | Phase 3 | Recruiting | Colgate Palmolive | 120 | 2026-07-20 | 2026-09-25 |
| Topical Phenytoin for Management of Gingival Recession phenytoin cream, Placebo - Gingival Recession | Phase 2 / Phase 3 | Not yet recruiting | Cairo University | 30 | 2026-06-01 | 2026-05-15 |
| Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 95 | 2026-05-18 | 2026-09-24 |
| To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis. Colgate SNaP Total 10/10, 1.5 Taurate, Colgate Great Regular Flavor Toothpaste, Flat Trimmed Extra Clean TB - Plaque, Dental, Gingivitis | Phase 3 | Active not recruiting | Colgate Palmolive | 85 | 2026-05-11 | 2026-05-27 |
| Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival Bleeding Toothpaste containing chitosan, Colgate Cavity Protection Toothpaste - Plaque, Dental, Gingivitis | Phase 3 | Not yet recruiting | Colgate Palmolive | 90 | 2026-04-01 | 2026-04-13 |
| Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial Xylitol Chewing gum, Sorbitol chewing gum - Preterm Birth, Low Birthweight Neonate | Phase 2 / Phase 3 | Recruiting | University of Washington | 6000 | 2026-03-26 | 2026-09-10 |
| Homemade Herbal Mouthwash in Gingivitis. A Randomized Clinical Trial. Chlorhexidine 0,12%, herbal Mouthwash - Gingivitis | Phase 3 | Not yet recruiting | Cairo University | 12 | 2026-02-01 | 2026-02-10 |
| Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis. 0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque | Phase 3 | Completed | Colgate Palmolive | 134 | 2026-01-26 | 2026-05-22 |
| Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth. Allium Sativum as an intracanal medicament - Apical Periodontitis, Periapical Radiolucency | Phase 3 | Not yet recruiting | University of Health Sciences Lahore | 96 | 2026-01-20 | 2026-01-06 |
| Comparative Evaluation of Oxygen-enriched and Chlorohexidine Mouthwashes as an Adjunct to Non-surgical Periodontal Therapy and Its Efficacy on Gingival Inflammation, Plaque Scores and Patient-reported Outcomes CHX mouthwash, Oxygen-enriched mouthwash - Periodontal Disease, Periodontal Diseases Inflammation | Phase 3 | Completed | Cairo University | 72 | 2025-12-01 | 2026-10-06 |
| Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash cetylpyridinium chloride (CPC), zinc lactate and sodium fluoride Mouthwash, sodium fluoride Mouthwash - Gingivitis, Plaque, Dental | Phase 3 | Completed | Colgate Palmolive | 80 | 2025-12-01 | 2026-05-26 |
| A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis Bimekizumab, Placebo - Palmoplantar Pustulosis | Phase 3 | Recruiting | UCB Biopharma SRL | 320 | 2025-11-14 | 2026-08-27 |
| The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament Diclofenac Sodium, Calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Recruiting | British University In Egypt | 48 | 2025-11-01 | 2025-05-30 |
Showing 20 of 202. Sign in to see all of them.
Gingivitis (51) · Periodontitis (44) · Chronic Periodontitis (41) · Dental Plaque (17) · Plaque, Amyloid (15) · Alveolar Bone Loss (12) · Gingival Recession (11) · Gingival Diseases (10) · Peri-Implantitis (8) · Gingival Hemorrhage (7) · Periapical Periodontitis (7) · Periodontal Pocket (6) · Aggressive Periodontitis (5) · Diabetes Mellitus, Type 2 (5)
Stomatognathic Diseases (202) · Mouth Diseases (199) · Pathological Conditions, Signs and Symptoms (68) · Gingival Diseases (63) · Pathologic Processes (57) · Infections (53) · Periodontitis (50) · Chronic Disease (41) · Disease Attributes (41) · Tooth Diseases (28) · Periodontal Atrophy (24) · Dental Deposits (18) · Musculoskeletal Diseases (15) · Pathological Conditions, Anatomical (15)
Triclosan (12) · Fluorides (11) · Tooth Exfoliation (11) · Chlorhexidine (7) · Metronidazole (7) · Root Planing (7) · hydrated silica gel-based toothpaste (7) · Amoxicillin (6) · Cetylpyridinium (5) · Metformin (5) · Minocycline (5) · Probiotics (5) · Toothpastes (5) · Rosuvastatin Calcium (4) · chlorhexidine gluconate (4)
Colgate Palmolive (34) · Government Dental College and Research Institute, Bangalore (24) · Cairo University (8) · Dr. D. Y. Patil Dental College & Hospital (7) · Al-Azhar University (5) · Islamic Azad University, Sanandaj (5) · University of Baghdad (5) · OraPharma (4) · Universidade Estadual Paulista Júlio de Mesquita Filho (4) · CD Pharma India Pvt. Ltd. (3) · Dow University of Health Sciences (3) · University of Milan (3) · Ain Shams University (2) · Alexandria University (2) · KLE Society's Institute of Dental Sciences (2)
United States (33) · India (26) · Egypt (20) · Brazil (16) · Italy (9) · China (8) · Spain (7) · Iraq (6) · Canada (5) · France (5) · Pakistan (5) · Germany (4) · United Kingdom (4) · Croatia (3) · Iran (3)
Magda Feres, Professor (3) · Cassiano K Rosing, PhD (2) · Chikara Ieda (2) · Deyu Hu, DDS, MS (2) · Giampietro Farronato, Professor (2) · Gianguido Cossellu, Fellow (2) · Gregory Seymour, BDS (2) · Luigi Montesani, DDS (2) · Mauro Santamaria, Professor (2) · So Ran Kwon, DDS, MS, PhD (2) · Yanfang Ren, DDS (2) · A Jayakumar, MDS (1) · A R Pradeep, MDS (1) · Adolfo Contreras, DDS, MS, PhD (1) · Ahmed Eldawy, doctor (1)
PMID 12897619, PMID 18573992, PMID 10477976, PMID 12839405, PMID 15016256, PMID 15316186, PMID 17079762, PMID 17668979, PMID 17716312, PMID 17716313, PMID 18454655, PMID 18596969, PMID 18672990, PMID 19563331, PMID 19711612, PMID 20151804, PMID 20348487, PMID 20354090, PMID 20831669, PMID 20840689, PMID 20937388, PMID 21085810, PMID 21133980, PMID 21269037, PMID 21324167, PMID 21357860, PMID 21422479, PMID 21482950, PMID 21513473, PMID 21692628, PMID 21897640, PMID 21939106, PMID 22028505, PMID 23016867, PMID 23055587, PMID 23055593, PMID 23071896, PMID 23176716, PMID 23205917, PMID 23253833, PMID 23649042, PMID 24024983, PMID 24080100, PMID 24310847, PMID 24346989, PMID 24495202, PMID 24685786, PMID 24698829, PMID 24850703, PMID 24992844
2008 (1), 2018 (1), 4UH3DE031129-02 (1), R01DE012215 (1), R01DE012872 (1), R01HD119029 (1), R01HD119055 (1), U01DE018886 (1), U01DE018902 (1)