126 completed, 7 not yet recruiting, 5 recruiting, 3 unknown. 83 Phase 3, 22 Phase 4, 21 Not applicable, 14 Phase 2, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Pre-Procedural CPC and Zinc Mouthwash in Reducing Dental Aerosols 0.09% CPC + Zinc Lactate Mouthwash, 0.2% Chlorhexidine Mouthwash, Water - Bacterial Contamination | Phase 4 | Not yet recruiting | Colgate Palmolive | 60 | 2026-10-08 | 2026-10-19 |
| Clinical Study Examining the Control of Plaque and Gingivitis Silica Free Meridol, Meridol, Colgate Dental Product - Gingivitis | Phase 3 | Not yet recruiting | Colgate Palmolive | 135 | 2026-10-01 | 2026-09-25 |
| CHEER Oral Health in Pregnancy Study Enhanced Care, Enhanced Care + - Gingivitis, Dental Health | Not applicable | Recruiting | University of California, San Francisco | 160 | 2026-09-29 | 2026-10-08 |
| Oral Hygiene Assistance Training Program Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash - Elderly, Periodontal Disease | Phase 4 | Not yet recruiting | Colgate Palmolive | 500 | 2026-09-20 | 2026-09-08 |
| Enamel Lesion Detection With New DX Tool BlueCheck, Prevident 5000ppm Booster Plus Toothpaste - Enamel Lesions, Caries | Phase 4 | Not yet recruiting | Colgate Palmolive | 5 | 2026-09-15 | 2026-09-14 |
| Clinical Study to Evaluate Remineralization Using an in Situ Model. Fluoride toothpaste containing 750 ppm MFP in a Dical base, Fluoride toothpaste containing 1450 ppm MFP in a Dical base, Fluoride-free toothpaste in a Dical base - Remineralization, Enamel Lesions | Phase 3 | Enrolling by invitation | Colgate Palmolive | 30 | 2026-09-03 | 2026-10-20 |
| Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses. Stannous Fluoride Toothpaste (SnF) - Gingival Inflammation | Phase 4 | Not yet recruiting | Colgate Palmolive | 20 | 2026-09-01 | 2026-09-03 |
| Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment Active Oral Hygiene Regimen, Placebo Oral Hygiene Regimen - Periodontal Disease, Gingival Inflammation and Bleeding | Phase 3 | Not yet recruiting | Colgate Palmolive | 100 | 2026-09-01 | 2026-09-03 |
| Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste - Plaque, Dental Plaque | Phase 3 | Recruiting | Colgate Palmolive | 120 | 2026-07-20 | 2026-09-25 |
| Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies 8% arginine + Zinc toothpaste, 5% Calcium Sodium Phosphosilicate toothpaste, 8% arginine toothpaste - Dentinal Sensitivity, Dentinal Hypersensitivity | Phase 3 | Recruiting | Colgate Palmolive | 132 | 2026-06-29 | 2026-08-07 |
| Clinical Investigation of Oral Malodor for Max Fresh Toothpaste Containing Zinc Citrate Versus a Commercially Available Regular Fluoride Toothpaste Max Fresh Toothpaste, Colgate Cavity Protection Toothpaste - Oral Malodor | Phase 3 | Completed | Colgate Palmolive | 80 | 2026-06-12 | 2026-10-20 |
| Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash - Diabetes Type 2, Periodontal Disease | Phase 4 | Enrolling by invitation | Colgate Palmolive | 10000 | 2026-05-26 | 2026-09-03 |
| Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 95 | 2026-05-18 | 2026-09-24 |
| To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis. Colgate SNaP Total 10/10, 1.5 Taurate, Colgate Great Regular Flavor Toothpaste, Flat Trimmed Extra Clean TB - Plaque, Dental, Gingivitis | Phase 3 | Active not recruiting | Colgate Palmolive | 85 | 2026-05-11 | 2026-05-27 |
| Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis sodium monofluorophosphate toothpaste - Gingivitis, Plaque | Phase 4 | Recruiting | Colgate Palmolive | 100 | 2026-04-20 | 2026-05-29 |
| Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival Bleeding Toothpaste containing chitosan, Colgate Cavity Protection Toothpaste - Plaque, Dental, Gingivitis | Phase 3 | Not yet recruiting | Colgate Palmolive | 90 | 2026-04-01 | 2026-04-13 |
| Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion New Toothpaste Containing SnF, Fluoride Toothpaste - Enamel Erosion | Phase 3 | Completed | Colgate Palmolive | 80 | 2026-03-03 | 2026-07-17 |
| Bacterial Reduction for a Manual Toothbrush With a 360-Degree Mouth Cleaner Design Versus a Standard Toothbrush Colgate 360 SupraClean Manual Toothbrush brush with 0.76% Na MFP, (1000 ppm F), Colgate Adult Extra Clean soft-bristle toothbrush brush with 0.76% Na MFP, (1000 ppm F) - Bacterial Load Reduction | Phase 3 | Completed | Colgate Palmolive | 56 | 2026-03-01 | 2026-06-12 |
| 6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health Test Mouthrinse, Control Mouthrinse - Gingivitis, Dental Plaque Accumulation | Phase 4 | Recruiting | Colgate Palmolive | 90 | 2026-01-28 | 2026-02-17 |
| Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis. 0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque | Phase 3 | Completed | Colgate Palmolive | 134 | 2026-01-26 | 2026-05-22 |
Showing 20 of 148. Sign in to see all of them.
Gingivitis (50) · Dental Plaque (37) · Plaque, Amyloid (16) · Dental Caries (14) · Periodontal Diseases (14) · Gingival Diseases (12) · Dentin Sensitivity (8) · Periodontitis (6) · Hypersensitivity (5) · COVID-19 (4) · Gingival Hemorrhage (4) · Diabetes Mellitus, Type 2 (3) · Coronavirus Infections (2) · Diabetes Mellitus (2) · Tooth Discoloration (2)
Triclosan (29) · hydrated silica gel-based toothpaste (24) · Fluorides (23) · Toothpastes (10) · fluorophosphate (10) · Cetylpyridinium (7) · Sodium Fluoride (6) · Tin Fluorides (6) · cytidylyl-(3'-5')-cytidine (5) · Arginine (4) · Supersmile (4) · Zinc (4) · chlorhexidine gluconate (4) · Amino Acids (3) · Centers for Disease Control and Prevention, U.S. (3)
United States (69) · Brazil (15) · China (11) · Thailand (9) · Italy (5) · Dominican Republic (4) · Germany (4) · Puerto Rico (4) · Australia (2) · Canada (2) · Colombia (2) · India (2) · Mexico (2) · Spain (2) · United Kingdom (2)
Cassiano K Rosing, PhD (3) · Deyu Hu, DDS, MS (3) · John Gallob, DMD (3) · Patricia Corby, DDS (3) · Terdphong Triratana (3) · Augusto R Elias-Boneta, DMD, MSD (2) · Bennet Amaechi, PhD, DDS (2) · Debora H Douek, PhD (2) · Farid Ayad (2) · Gregory Seymour, BDS (2) · Luigi Montesani, DDS (2) · Terdphong Triratana, DDS (2) · Yanfang Ren, DDS (2) · Yiming Li, DDS MSD PhD (2) · Abdul Rashid Ismail, BDS (1)
PMID 11799281, PMID 26087570, PMID 33375475, PMID 35570015, PMID 37885337, PMID 38130922, PMID 38217757, PMID 39910536, PMID 40009628, PMID 41553854
R01DE012215 (1)